Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Todd Scheuer"'
Autor:
Franck Kalume, John C. Oakley, Ruth E. Westenbroek, Jennifer Gile, Horacio O. de la Iglesia, Todd Scheuer, William A. Catterall
Publikováno v:
Neurobiology of Disease, Vol 77, Iss , Pp 141-154 (2015)
Dravet Syndrome (DS) is caused by heterozygous loss-of-function mutations in voltage-gated sodium channel NaV1.1. Our mouse genetic model of DS recapitulates its severe seizures and premature death. Sleep disturbance is common in DS, but its mechanis
Externí odkaz:
https://doaj.org/article/b314935a52a54e599be040ad91f6eb73
Autor:
Moran Rubinstein, Ruth E. Westenbroek, Frank H. Yu, Christina J. Jones, Todd Scheuer, William A. Catterall
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 106-117 (2015)
Dominant loss-of-function mutations in voltage-gated sodium channel NaV1.1 cause Dravet Syndrome, an intractable childhood-onset epilepsy. NaV1.1+/− Dravet Syndrome mice in C57BL/6 genetic background exhibit severe seizures, cognitive and social im
Externí odkaz:
https://doaj.org/article/9bfdec89a6fd49b1a551dc468c52ccd8
Publikováno v:
Toxins, Vol 11, Iss 9, p 513 (2019)
Brevetoxins are produced by dinoflagellates such as Karenia brevis in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the
Externí odkaz:
https://doaj.org/article/affbf8b639ca4f539e9ef2120f956c94
Autor:
Ian B. Stanaway, Wendy H. Raskind, Moran Rubinstein, Todd Scheuer, Marilyn Archer, E McCord, Ellen M. Wijsman, Ryan R. Nesbitt, Ashok Patowary, Deborah A. Nickerson, William A. Catterall, Raphael Bernier, Zoran Brkanac
Publikováno v:
Molecular Psychiatry
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder often accompanied by intellectual disability, language impairment and medical co-morbidities. The heritability of autism is high and multiple genes have been implicated as causal
Publikováno v:
Toxins, Vol 11, Iss 9, p 513 (2019)
Toxins
Volume 11
Issue 9
Toxins
Volume 11
Issue 9
Brevetoxins are produced by dinoflagellates such as Karenia brevis in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the
Autor:
Todd Scheuer, Frank H. Yu, Christina J. Jones, Ruth E. Westenbroek, William A. Catterall, Moran Rubinstein
Publikováno v:
Neurobiology of Disease, Vol 73, Iss, Pp 106-117 (2015)
Dominant loss-of-function mutations in voltage-gated sodium channel NaV1.1 cause Dravet Syndrome, an intractable childhood-onset epilepsy. NaV1.1(+/-) Dravet Syndrome mice in C57BL/6 genetic background exhibit severe seizures, cognitive and social im
Autor:
Karina Leal, Todd Scheuer, Gilbert Q. Martinez, William A. Catterall, Jin Yan, Evanthia Nanou, Venkat Giri Magupalli
Publikováno v:
Molecular and Cellular Neuroscience. 63:124-131
Facilitation and inactivation of P/Q-type Ca2+ currents mediated by Ca2+/calmodulin binding to Ca(V)2.1 channels contribute to facilitation and rapid depression of synaptic transmission, respectively. Other calcium sensor proteins displace calmodulin
Publikováno v:
Neuron. 81(6):1282-1289
SummaryAutism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have been tested in ASD, but only limited success has been achieved. Here we report that
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(46)
Many forms of short-term synaptic plasticity rely on regulation of presynaptic voltage-gated Ca2+ type 2.1 (CaV2.1) channels. However, the contribution of regulation of CaV2.1 channels to other forms of neuroplasticity and to learning and memory are
Autor:
Jian Payandeh, Gilbert Q. Martinez, Ning Zheng, Todd Scheuer, Lin Tang, Teresa M. Heard, William A. Catterall, Tamer M. Gamal El-Din
Publikováno v:
Nature
Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca(2+) into cells despite a 70-fold higher extracellular concentration of Na(+). How CaV channels solve this fundamental biophysical problem remains unclear. Here we repo