Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Todd S. Macfarlan"'
Autor:
Guillaume Bourque, Kathleen H. Burns, Mary Gehring, Vera Gorbunova, Andrei Seluanov, Molly Hammell, Michaël Imbeault, Zsuzsanna Izsvák, Henry L. Levin, Todd S. Macfarlan, Dixie L. Mager, Cédric Feschotte
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional
Externí odkaz:
https://doaj.org/article/0c9449d64f8a4833a29a40cd990696c0
Autor:
Guojia Xie, Ji-Eun Lee, Anna D. Senft, Young-Kwon Park, Younghoon Jang, Shreeta Chakraborty, Joyce J. Thompson, Kaitlin McKernan, Chengyu Liu, Todd S. Macfarlan, Pedro P. Rocha, Weiqun Peng, Kai Ge
Publikováno v:
Nature Genetics. 55:693-705
Autor:
Cui Du, Jing Jiang, Yuzhuo Li, Miao Yu, Jian Jin, Shuai Chen, Hairui Fan, Todd S. Macfarlan, Bin Cao, Ming-an Sun
Publikováno v:
Genome Research. 33:197-207
The placenta is an organ with extraordinary phenotypic diversity in eutherian mammals. Recent evidence suggests that numerous human placental enhancers are evolved from lineage-specific insertions of endogenous retroviruses (ERVs), yet the transcript
Autor:
Jinpu Jin, Sherry Ralls, Elaine Wu, Gernot Wolf, Ming-An Sun, Danielle A. Springer, Rachel L. Cosby, Anna D. Senft, Todd S. Macfarlan
Mammalian brains are larger and more densely packed with neurons than reptiles, but the genetic mechanisms underlying the increased connection complexity amongst neurons are unclear. The expression diversity of clustered protocadherins (Pcdhs), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7869e26e74e2493c4da3a720b5a5bc94
https://doi.org/10.1101/2023.05.08.539838
https://doi.org/10.1101/2023.05.08.539838
Autor:
Caitlin E Dunn-Fletcher, Lisa M Muglia, Mihaela Pavlicev, Gernot Wolf, Ming-An Sun, Yueh-Chiang Hu, Elizabeth Huffman, Shivani Tumukuntala, Katri Thiele, Amrita Mukherjee, Sandra Zoubovsky, Xuzhe Zhang, Kayleigh A Swaggart, Katherine Y Bezold Lamm, Helen Jones, Todd S Macfarlan, Louis J Muglia
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2006337 (2018)
Pregnancy and parturition are intricately regulated to ensure successful reproductive outcomes. However, the factors that control gestational length in humans and other anthropoid primates remain poorly defined. Here, we show the endogenous retrovira
Externí odkaz:
https://doaj.org/article/5187b61a9cc04b9bb9eb293210d8a053
Autor:
Todd S. Macfarlan, Anna D. Senft
Publikováno v:
Nature Reviews Genetics. 22:691-711
Transposable elements (TEs) promote genetic innovation but also threaten genome stability. Despite multiple layers of host defence, TEs actively shape mammalian-specific developmental processes, particularly during pre-implantation and extra-embryoni
Autor:
Louis J. Muglia, Gernot Wolf, Ming-an Sun, Caitlin E. Dunn-Fletcher, Sherry Ralls, Anna D. Senft, Yejun Wang, Todd S. Macfarlan, Jinpu Jin
Publikováno v:
Mol Biol Evol
In mammals, the placenta mediates maternal–fetal nutrient and waste exchange and acts in an immunomodulatory way to facilitate maternal–fetal tolerance. The placenta is highly diverse across mammalian species, yet the molecular mechanisms that di
Autor:
Cui Du, Jing Jiang, Yuzhuo Li, Miao Yu, Jian Jin, Shuai Chen, Hairui Fan, Todd S. Macfarlan, Bin Cao, Ming-an Sun
The placenta is an organ with extraordinary phenotypic diversity in eutherian mammals. Recent evidence suggests that numerous human placental enhancers are evolved from lineage-specific insertions of endogenous retroviruses (ERVs), yet the transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff22b76d886ca7d198d23fdce9937a29
https://doi.org/10.1101/2022.08.02.502490
https://doi.org/10.1101/2022.08.02.502490
Autor:
Laura Sala, Srividya Chandrasekhar, Rachel L. Cosby, Gaspare La Rocca, Todd S. Macfarlan, Parirokh Awasthi, Raj Chari, Michael Kruhlak, Joana A. Vidigal
Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway with essential roles in development and disease. Yet, little is known about its regulation in vivo. Here, we show that in quiescent mouse splenocytes, AGO2 localizes almost exclusivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b0b33c06f002cce48027e66689a562
https://doi.org/10.1101/2022.07.17.500356
https://doi.org/10.1101/2022.07.17.500356
Autor:
Claude Warzecha, Anup Dey, Peter D. Adams, Tiyun Wu, Todd S. Macfarlan, Mahesh Bachu, Ming-an Sun, Paul E. Love, Keiko Ozato, Chao Chen
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2136-2149.e4 (2020)
Summary: HIRA is a histone chaperone that deposits the histone variant H3.3 in transcriptionally active genes. In DiGeorge syndromes, a DNA stretch encompassing HIRA is deleted. The syndromes manifest varied abnormalities, including immunodeficiency