Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Todd Robert Ryder"'
Autor:
Minkoo Ji, Alberto Podjarny, Yung Lee, M. Andreoli, Erik Jagdmann, Bruce R. Conway, Ryan Sheeler, Darren Whitehouse, Czestkowski Wojciech J, Adam Golebiowski, Jacek Olczak, Andre Mitschler, Alexandra Cousido-Siah, Wieslawa Piotrowska, Todd Robert Ryder, Marzena Mazur, Michael C. Van Zandt, F.X. Ruiz, Paul Beckett, Hagen Schroeter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4837-4841
The Ugi reaction has been successfully applied to the synthesis of novel arginase inhibitors. In an effort to decrease conformational flexibility of the previously reported series of 2-amino-6-boronohexanoic acid (ABH) analogs 1, we designed and synt
Autor:
F.X. Ruiz, Alexandra Cousido-Siah, Alberto Podjarny, Todd Robert Ryder, Erik Jagdmann, Adam Golebiowski, M. Andreoli, Michael C. Van Zandt, Darren Whitehouse, Hagen Schroeter, Paul Beckett, Adam W. Mazur, Manyian Padmanilayam, Minkoo Ji, Andre Mitschler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2027-2030
Substitution at the alpha center of the known human arginase inhibitor 2-amino-6-boronohexanoic acid (ABH) is acceptable in the active site pockets of both human arginase I and arginase II. In particular, substituents with a tertiary amine linked via
Autor:
Adam Golebiowski, G. Erik Jagdmann, Minkoo Ji, Alberto Podjarny, Michael C. Van Zandt, F.X. Ruiz, M. Andreoli, Mingbao Zhang, Alexandra Cousido-Siah, Todd Robert Ryder, Hagen Schroeter, Gerard D'Angelo, Darren Whitehouse, Keyvan Mahboubi, Paul Beckett, Andre Mitschler, Eduardo I. Howard, Bruce R. Conway, Ryan Sheeler
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in the discovery of a novel series of highly potent α,α-disubstituted amino acid-based arginase inhibitors. The lead candidate, (R)-2-amino-6-borono-2-(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135605c834a45897a482459070c05460
http://pubs.acs.org/doi/abs/10.1021/jm400014c
http://pubs.acs.org/doi/abs/10.1021/jm400014c
Autor:
Michael Francis Rafferty, Katalin Tarczy-Hornoch, Balazs G. Szoke, Lain-Yen Hu, Todd Robert Ryder, Elizabeth Millerman
Publikováno v:
ChemInform. 30
Selective N-type Voltage Sensitive Calcium Channel (VSCC) blockers have shown utility in several models of stroke and pain. A series of N , N -dialkyldipeptidylamines with potent functional activity at N-type VSCC's has been identified. Multiple para
Autor:
Susan M. Lotarski, Lain Yen Hu, Todd Robert Ryder, Balazs G. Szoke, M.Rose Feng, Charles Taylor, Michael Francis Rafferty, Elizabeth Millerman, Be Sheng Kuo, George P. Miljanich, Krista M. Siebers
Publikováno v:
Bioorganicmedicinal chemistry. 8(6)
Our drug discovery efforts for N-type calcium channel blockers in the 4-piperidinylaniline series led to the discovery of an orally active analgesic agent 26.1-[4-Dimethylamino-benzyl)-piperidin-4-yl]-[4-(3,3-dimethyl-but yl)-phenyl]-(3-methyl-but-2-
Autor:
G P Miljanich, Mark L. Weber, David M. Rock, B G Szoke, Lain-Yen Hu, Sally J. Stoehr, Todd Robert Ryder, Michael Sinz, Michael Francis Rafferty, Elizabeth Millerman, Yong-Xiang Wang, Susan M. Lotarski, S. Scott Bowersox, Charles Taylor, M R Feng
Publikováno v:
Journal of medicinal chemistry. 42(20)
In this article, the rationale for the design, synthesis, and biological evaluation of a series of N-type voltage-sensitive calcium channel (VSCC) blockers is described. N-Type VSCC blockers, such as ziconotide, have shown utility in several models o
Autor:
Elizabeth Millerman, Balazs G. Szoke, Susan M. Lotarski, Michael Francis Rafferty, David M. Rock, George P. Miljanich, Lain-Yen Hu, Todd Robert Ryder, Charles Taylor, Mark L. Weber, Sally J. Stoehr
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(16)
Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.
Autor:
Balazs G. Szoke, Sham Shridhar Nikam, Elizabeth Millerman, Todd Robert Ryder, Lain-Yen Hu, Michael Francis Rafferty
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(8)
Selective N-type Voltage Activated Calcium Channel (VACC) blockers have shown utility in several models of stroke and pain. In the process of searching for small molecules as N-type calcium channel blockers, we have identified a series of N,N-dialkyl
Autor:
Susan M. Lotarski, Mark G. Vartanian, Michael Francis Rafferty, Wayne L. Cody, Elizabeth Millerman, Yuntao Song, Balazs G. Szoke, Sally J. Stoehr, Mark L. Weber, David M. Rock, George P. Miljanich, Lain-Yen Hu, Todd Robert Ryder, Charles Taylor
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(6)
Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown utility in several models of stroke and pain. We are especially interested in small molecule N-type calcium channel blockers for therapeutic use. Herein, we report a series
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(17)
Optimization of a 2-step reaction sequence was accomplished in 3-4 days, with over 200 different reaction conditions evaluated. Combinatorial arrays were performed using the optimized conditions to synthesize 590 new compounds which were tested for i