Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Todd Richmann"'
Autor:
Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target. The X-ray crystal structure of the KasA-DG167 compl
Externí odkaz:
https://doaj.org/article/8d6c465583e4410c8afdd48c4a9a3287
Autor:
Carly Levine, Ravindra Jadhav, Yan Pan, Kholiswa Tsotetsi, Xin Wang, Divya Awasthi, Courtney Grady, Anil Shelke, Samer S. Daher, Todd Richmann, Riju Shrestha, Paridhi Sukheja, Jimmy Patel, Pamela R. Barnett, Ryan J. Dikdan, Thomas Kim, Riccardo Russo, Jennifer Hanna, Matthew Zimmerman, Véronique Dartois, Joel S. Freundlich, David Alland, Pradeep Kumar
Rapid emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is one of the most significant healthcare challenges of our time. The cause of drug resistance is multifactorial, with the long course anti-tubercular therapy required to treat tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::176fabd6ea174ad6e44aef61a06bd534
https://doi.org/10.1101/2022.07.05.496887
https://doi.org/10.1101/2022.07.05.496887
Autor:
Xin Wang, Liping Li, Paridhi Sukheja, David Alland, Kholiswa Tsotetsi, Hsin Pin Ho Liang, David S. Perlin, Véronique Dartois, Todd Richmann, Courtney Grady, Glenn C. Capodagli, Matthew B. Neiditch, Riju Shrestha, Pradeep Kumar, Nancy D. Connell, Joel S. Freundlich, Ravindra Jadhav, Matthew D. Zimmerman, Marizel Mina, Steven Park, Riccardo Russo, Shao-Gang Li, Yong Mo Ahn, Daigo Inoyama, Divya Awasthi
Publikováno v:
Cell Chem Biol
Summary Published Mycobacterium tuberculosis β-ketoacyl-ACP synthase KasA inhibitors lack sufficient potency and/or pharmacokinetic properties. A structure-based approach was used to optimize existing KasA inhibitor DG167. This afforded indazole JSF
Autor:
Riju Shrestha, Matthew D. Zimmerman, Karishma Maharaja, Padmini Salgame, Divya Awasthi, Joel S. Freundlich, Glenn C. Capodagli, Aditi Gupta, David Alland, Hsin Pin Ho Liang, Alexander L. Perryman, Gene Porter, Riccardo Russo, Gautam Agnihotri, Roxanne Morris, Véronique Dartois, Marizel Mina, Sean Ekins, Sheetal Verma, Daigo Inoyama, Kyu Y. Rhee, Paridhi Sukheja, Patricia Soteropoulos, George Rasic, Jansy Sarathy, Todd Richmann, Zhe Wang, Nancy D. Connell, Eric Singleton, Matthew B. Neiditch, Seema Husain, Pradeep Kumar, Shao-Gang Li
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e02101-17 (2018)
mBio
mBio, Vol 9, Iss 6, p e02101-17 (2018)
mBio
Cell wall biosynthesis inhibitors have proven highly effective for treating tuberculosis (TB). We discovered and validated members of the indazole sulfonamide class of small molecules as inhibitors of Mycobacterium tuberculosis KasA—a key component
Autor:
Hsin Pin Ho, David Alland, Eric Singleton, Véronique Dartois, Mark Jaskowski, Todd Richmann, Riju Shrestha, Pradeep Kumar, Ricardo Gallardo-Macias, Matthew D. Zimmerman, Nancy D. Connell, Riccardo Russo, Joel S. Freundlich
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(4)
The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular acti