Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Todd R Harris"'
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176571 (2017)
Recently, dibenzylurea-based potent soluble epoxide hydrolase (sEH) inhibitors were identified in Pentadiplandra brazzeana, a plant in the order Brassicales. In an effort to generalize the concept, we hypothesized that plants that produce benzyl gluc
Externí odkaz:
https://doaj.org/article/4bba82b96ab94d199b06cc72448559bd
Autor:
Amy A. Rand, Anita Rajamani, Sean D. Kodani, Todd R. Harris, Lukas Schlatt, Bodgan Barnych, Anthony G. Passerini, Bruce D. Hammock
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 1996-2005 (2019)
Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors. This
Externí odkaz:
https://doaj.org/article/94c1bac4420240c9a574f864c97208b8
Autor:
Todd R. Harris, Julie A. Griffith, Colleen E. C. Clarke, Krista L. Garner, Elizabeth C. Bowdridge, Evan DeVallance, Kevin J. Engles, Thomas P. Batchelor, William T. Goldsmith, Kim Wix, Timothy R. Nurkiewicz, Amy A. Rand
Publikováno v:
Environmental Science: Advances. 2:740-748
A LC-MS/MS based platform is used to gain a global perspective on shifts in oxylipids, signaling molecules derived from dietary lipids that modulate the inflammatory response, after nano-TiO2 inhalation exposure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::832e39c7ebd0c7f1e048bce0fb0f9f37
https://doi.org/10.1039/d2va00300g
https://doi.org/10.1039/d2va00300g
Autor:
Bruce D. Hammock, Bodgan Barnych, Sean D. Kodani, Lukas Schlatt, Anthony G. Passerini, Amy A. Rand, Todd R. Harris, Anita Rajamani
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 1996-2005 (2019)
Journal of lipid research, vol 60, iss 12
J Lipid Res
Journal of lipid research, vol 60, iss 12
J Lipid Res
Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e869a2462d26b8b10159dac5117b0025
http://www.sciencedirect.com/science/article/pii/S0022227520310397
http://www.sciencedirect.com/science/article/pii/S0022227520310397
Autor:
Christophe Morisseau, Briana Hamamoto, Vengai Mavangira, Bruce D. Hammock, Todd R. Harris, Diyala S. Shihadih, Alonso G. P. Guedes, Sean D. Kodani, Sung Hee Hwang, Kin Sing Stephen Lee
Publikováno v:
Frontiers in Veterinary Science
Frontiers in Veterinary Science, Vol 7 (2020)
Frontiers in Veterinary Science, Vol 7 (2020)
The veterinary pharmacopeia available to treat pain and inflammation is limited in number, target of action and efficacy. Inhibitors of soluble epoxide hydrolase (sEH) are a new class of anti-inflammatory, pro-resolving and analgesic drugs being test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f483b9dea3ee96410e86ecbc388e11c7
https://pubmed.ncbi.nlm.nih.gov/33005645
https://pubmed.ncbi.nlm.nih.gov/33005645
Autor:
René Blöcher, Bogdan Barnych, Sung Hee Hwang, Christophe Morisseau, Todd R. Harris, Karen Wagner, Bruce D. Hammock, Hao Wu, Raghavender Reddy Gopireddy, Ewgenij Proschak, Yang Kevin Xiang
Publikováno v:
Journal of medicinal chemistry, vol 61, iss 8
Inspired by previously discovered enhanced analgesic efficacy between soluble epoxide hydrolase (sEH) and phosphodiesterase 4 (PDE4) inhibitors, we designed, synthesized and characterized 21 novel sEH/PDE4 dual inhibitors. The best of these displayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c9a30185f52c119702c474996b1c1e
https://escholarship.org/uc/item/6bg1v18m
https://escholarship.org/uc/item/6bg1v18m
Autor:
Sung-Hee Hwang, Alonso G. P. Guedes, Kin Sing Stephen Lee, Bruce D. Hammock, Todd R. Harris, Diyala S. Shihadih, Briana Hamamoto, Sean D. Kodani, Christophe Morisseau
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e597ae1445052082d19a759ffbcdf8
https://doi.org/10.1096/fasebj.2018.32.1_supplement.559.5
https://doi.org/10.1096/fasebj.2018.32.1_supplement.559.5
Autor:
Sean D. Kodani, Amy A. Rand, Denise M. Imai, Sung Hee Hwang, Bruce D. Hammock, Todd R. Harris, Jun Yang
Publikováno v:
Molecular pharmacology, vol 94, iss 2
The cyclooxygenase-2 (COX-2) selective inhibitor celecoxib is widely used in the treatment of pain and inflammation. Celecoxib has been explored as a possible treatment of liver fibrosis with contradictory results, depending on the model. The present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a2f22bf7d0583ccfb6f9489ab19594
https://pubmed.ncbi.nlm.nih.gov/29844231
https://pubmed.ncbi.nlm.nih.gov/29844231
Adamantyl groups are widely used in medicinal chemistry. However, metabolism limits their usage. Herein, we report the first systematic study of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0db7b97fb6af57b7dadaaace23e9905
https://europepmc.org/articles/PMC5837815/
https://europepmc.org/articles/PMC5837815/
Autor:
Diyala S. Shihadih, Todd R. Harris, Christophe Morisseau, Jun Yang, Bruce D. Hammock, Kin Sing Stephen Lee, Oleg Merzlikin
Publikováno v:
Bioorganic & medicinal chemistry letters, vol 25, iss 2
In vertebrates, soluble epoxide hydrolase (sEH) hydrolyzes natural epoxy-fatty acids (EpFAs), which are chemical mediators modulating inflammation, pain, and angiogenesis. Chick embryos are used to study angiogenesis, particularly its role in cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f770f201075862c09c62f7b08bbc06
https://doi.org/10.1016/j.bmcl.2014.11.053
https://doi.org/10.1016/j.bmcl.2014.11.053