Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Todd O, Yeates"'
Autor:
Justin E. Miller, Roger Castells-Graells, Mark A. Arbing, Aldo Munoz, Yi-Xiao Jiang, Charlize T. Espinoza, Brian Nguyen, Paul Moroz, Todd O. Yeates
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1122 (2023)
Beta-2 microglobulin (B2M) is an immune system protein that is found on the surface of all nucleated human cells. B2M is naturally shed from cell surfaces into the plasma, followed by renal excretion. In patients with impaired renal function, B2M wil
Externí odkaz:
https://doaj.org/article/01d9fa7c6def4492906eadd72a84cd95
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Proteins smaller than about 50 kDa are currently too small to be imaged at high resolution by cryo‐electron microscopy (cryo‐EM). Here authors design a protein scaffold that binds 12 copies of a small 26 kDa protein (GFP), which allowed visualizi
Externí odkaz:
https://doaj.org/article/3e07cb910a3049f3b5bdc9609bc1350e
Autor:
Andrew Stewart, Philip Dershwitz, Charles Stewart, Michael R. Sawaya, Todd O. Yeates, Jeremy D. Semrau, Hans Zischka, Alan A. DiSpirito, Thomas A. Bobik
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 79:111-118
Methanobactins (MBs) are ribosomally produced and post-translationally modified peptides (RiPPs) that are used by methanotrophs for copper acquisition. The signature post-translational modification of MBs is the formation of two heterocyclic groups,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7558dc3e9f70710cdd67d0f344898eaa
https://doi.org/10.1107/s2053230x23003035
https://doi.org/10.1107/s2053230x23003035
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248269 (2021)
Bacterial microcompartments are organelle-like structures composed entirely of proteins. They have evolved to carry out several distinct and specialized metabolic functions in a wide variety of bacteria. Their outer shell is constructed from thousand
Externí odkaz:
https://doaj.org/article/dc371453c5cd448abb6fedc29ddf9356
Publikováno v:
F1000Research, Vol 9 (2020)
Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative.
Externí odkaz:
https://doaj.org/article/eca6814bd15a4940bfcd7034752fd909
Autor:
Justin E. Miller, Yashes Srinivasan, Nithin P. Dharmaraj, Andrew Liu, Phillip L. Nguyen, Scott D. Taylor, Todd O. Yeates
Publikováno v:
Journal of the American Chemical Society. 144:12681-12689
Proteins that self-assemble into enclosed polyhedral cages, both naturally and by design, are garnering attention for their prospective utility in the fields of medicine and biotechnology. Notably, their potential for encapsulation and surface displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c235987f967e75a4bf2aaa5bc6dc68c2
https://doi.org/10.1021/jacs.2c02165
https://doi.org/10.1021/jacs.2c02165
Autor:
Michael R. Sawaya, Nancy Leon-Rivera, Andrea A Acosta, Xavier Escoto, Jessica M Ochoa, Todd O. Yeates, Oscar Mijares, Joanna D Marshall
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Bacterial microcompartments are large supramolecular structures comprising an outer proteinaceous shell that encapsulates various enzymes in order to optimize metabolic processes. The outer shells of bacterial microcompartments are made of several th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2877e2ed7ab91351c21a6be4a2fae9c
https://doi.org/10.1107/s2053230x21007470
https://doi.org/10.1107/s2053230x21007470
Autor:
Roger Castells-Graells, Kyle Meador, Mark A. Arbing, Michael R. Sawaya, Morgan Gee, Duilio Cascio, Emma Gleave, Judit É. Debreczeni, Jason Breed, Chris Phillips, Todd O. Yeates
Numerous technical advances have made cryo-EM an attractive method for atomic structure determination. Cryo-EM is ideally suited for large macromolecular structures, while problems of low signal-to-noise prevent routine structure determination of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66a660e313b807d2de9725cea7726274
https://doi.org/10.1101/2022.09.18.508009
https://doi.org/10.1101/2022.09.18.508009
The computer artificial intelligence system AlphaFold has recently predicted previously unknown three-dimensional structures of thousands of proteins. Focusing on the subset with high-confidence scores, we algorithmically analyze these predictions fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16032418b332db0732d4c15ce68ea4af
http://arxiv.org/abs/2207.07410
http://arxiv.org/abs/2207.07410
Autor:
Todd O. Yeates, Joshua Laniado
Publikováno v:
Proc Natl Acad Sci U S A
Diverse efforts in protein engineering are beginning to produce novel kinds of symmetric self-assembling architectures, from protein cages to extended two-dimensional (2D) and three-dimensional (3D) crystalline arrays. Partial theoretical frameworks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee41a0f19f416cb042c8cbb449b715e
https://doi.org/10.1073/pnas.2015183117
https://doi.org/10.1073/pnas.2015183117