Výsledky vyhledávání - "Todd Matthew Morgan"

Inherited risk for prostate cancer (PCa): Following the natural history of men with high-risk genetics using multiparametric MRI (mpMRI)

Autor: Anna Couvillon, Baris Turkbey, Peter L. Choyke, Katherine Lee-Wisdom, Yolanda McKinney, Robert Sidlow, Michael P. Mullane, Veda N. Giri, Todd Matthew Morgan, Heather H. Cheng, Maria J. Merino, William Douglas Figg, Peter A. Pinto, William L. Dahut, Fatima Karzai

Publikováno v: Journal of Clinical Oncology. 41:390-390

390 Background: PCa has inherited risk factors including high genetic risk variants such as BRCA1/2, HOXB13, and DNA mismatch repair genes. mpMRI has been shown to be effective for detection and staging of localized PCa. This study follows participan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c16d402381723be3c38899fe933dd67
https://doi.org/10.1200/jco.2023.41.6_suppl.390

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Patient-level data meta-analysis of a multi-modal artificial intelligence (MMAI) prognostic biomarker in high-risk prostate cancer: Results from six NRG/RTOG phase III randomized trials

Publikováno v: Journal of Clinical Oncology. 41:299-299

299 Background: Recently, an MMAI prognostic biomarker, ArteraAI Prostate, was trained and validated in localized prostate cancer to more accurately risk stratify patients for multiple endpoints compared to NCCN risk groups (Esteva et al., 2022). Pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eb7e0805a8c68eed76df8e6a33032cd
https://doi.org/10.1200/jco.2023.41.6_suppl.299

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Determining the impact of genomic classifier testing on patient-reported quality of life after prostatectomy: Results from the G-MINOR randomized trial

Publikováno v: Journal of Clinical Oncology. 41:345-345

345 Background: Decipher is a tissue-based genomic classifier (GC) developed and validated in the post-radical prostatectomy (RP) setting to help guide adjuvant treatment decisions for prostate cancer (PCa). We conducted the first prospective, random

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07d008e87989b2c6adcf1fad8d2cc423
https://doi.org/10.1200/jco.2023.41.6_suppl.345

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Prostate cancer risk in African American men evaluated via digital histopathology multi-modal deep learning models developed on NRG Oncology phase III clinical trials

Publikováno v: Journal of Clinical Oncology. 40:108-108

108 Background: Artificial intelligence (AI) tools can display racial bias as a result of existing systemic health inequities and biased datasets. We have previously developed multi-modal AI (MMAI) prognostic models based on digital pathology images

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f56917da6f6b512005a5c5c9f9df024
https://doi.org/10.1200/jco.2022.40.16_suppl.108

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Development and validation of a prognostic AI biomarker using multi-modal deep learning with digital histopathology in localized prostate cancer on NRG Oncology phase III clinical trials

Publikováno v: Journal of Clinical Oncology. 40:222-222

222 Background: Prognostication in localized prostate cancer is reliant on non-specific tools, an issue that leads to the over- and under-treatment of patients. Various tissue-based molecular biomarkers have attempted to fill this unmet need, but mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5070e0c1c3a7d289679e394c9b56d4b4
https://doi.org/10.1200/jco.2022.40.6_suppl.222

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Molecular characterization to delineate the clonal evolution of primary prostate cancer with synchronous lymph node metastasis

Autor: Udit Singhal, Srinivas Nallandhighal, Jeffrey J. Tosoian, Trinh Pham, Chia-Jen Liu, Razeen Kareem, Komal Ramesh Kunder, Todd Matthew Morgan, Roberta Lucianò, Shahrokh F Shariat, Lucia Dambrosio, Claudio Doglioni, Scott A. Tomlins, Alberto Briganti, Ganesh S. Palapattu, Aaron M. Udager, Simpa Salami

Publikováno v: Journal of Clinical Oncology. 40:266-266

266 Background: Primary prostate cancers (PCa) harbor multiple spatially distinct tumors with significant inter-lesion molecular heterogeneity. This diversity can result in many subclones that compete for biological and clinical dominance. The defini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f029ad3183e320669e7f2e6d49b4ca4
https://doi.org/10.1200/jco.2022.40.6_suppl.266

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Prognostic value and therapeutic implications of an integrative molecular subtype and immune content classifier in localized muscle-invasive bladder cancer

Autor: Mark Farha, Brittney Cotta, Randy Vince, Srinivas Nallandhighal, Samuel D. Kaffenberger, Philip Palmbos, Ajjai Shivaram Alva, Todd Matthew Morgan, Ganesh S. Palapattu, Simpa Salami, Aaron M. Udager

Publikováno v: European Urology. 81:S1319

530 Background: Localized muscle-invasive bladder cancer (MIBC) exhibits heterogeneous molecular features and outcomes, with a 5-year mortality rate of approximately 30%. Immune checkpoint blockade (ICB) has the potential to improve oncological outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2970339f31a3b6bb0ed6328ff47c5069
https://doi.org/10.1016/s0302-2838(22)00971-x

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RTOG 3506 (STEEL): A study of salvage radiotherapy with or without enzalutamide in recurrent prostate cancer following surgery

Autor: Edwin Melencio Posadas, Hiram Alberto Gay, Stephanie L. Pugh, Todd Matthew Morgan, James B. Yu, Stanislav Lechpammer, Felix Y Feng

Publikováno v: Journal of Clinical Oncology. 38:TPS5601-TPS5601

TPS5601 Background: Salvage radiotherapy (SRT) is an important intervention for men with prostate cancer (PCa) who experience biochemical recurrence (BCR) after radical prostatectomy (RP). These patients are in need of cure or else they will develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68fcfe70e87172df58e3ba100d47f4de
https://doi.org/10.1200/jco.2020.38.15_suppl.tps5601

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