Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Todd Macklin"'
Autor:
Todd Macklin, Mark Carlton, Hopkins Maria, Stephen Hitchcock, Hans H Schiffer, Deanna R Collia, Steve Moore, Kikuchi Shota, Nicole Marion English, Mark L. Adams, Murphy Sean, William J. Ray, Jason Green, Jason W. Brown, Holger Monenschein, Huikai Sun, Nicola Brice, Holly Reichard, Nidhi Kaushal
Publikováno v:
Journal of medicinal chemistry. 64(14)
Parkinson's disease (PD) is a chronic and progressive movement disorder with the urgent unmet need for efficient symptomatic therapies with fewer side effects. GPR6 is an orphan G-protein coupled receptor (GPCR) with highly restricted expression in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a916c19bb4b6311dc8964de6bf626764
https://pubmed.ncbi.nlm.nih.gov/33861086
https://pubmed.ncbi.nlm.nih.gov/33861086
Autor:
Glenn C. Micalizio, Todd Macklin
Publikováno v:
Nature chemistry
Skipped polyenes (that is, 1,4-dienes and higher homologues) are stereodefined components of a vast array of biologically important natural products, including polyunsaturated fatty acids. Although widespread in nature, these architectures are genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb7e68f30dcfc0929ea0a8613ff9216
http://europepmc.org/articles/PMC2909609
http://europepmc.org/articles/PMC2909609
Publikováno v:
Angewandte Chemie. 120:2127-2131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4217fa7c02a9ac760dab2a05048007dc
https://doi.org/10.1002/ange.200704360
https://doi.org/10.1002/ange.200704360
Publikováno v:
European Journal of Organic Chemistry. 2008:1507-1509
A short synthesis of the alkaloid schumanniophytine (1) starting from simple building blocks and involving directed ortho metalation (DoM), Suzuki–Miyaura cross coupling, and a key ortho-silicon-induced O-carbamate remote anionic Fries rearrangemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a650570475ca5efca19efed6d76be9d
https://doi.org/10.1002/ejoc.200701116
https://doi.org/10.1002/ejoc.200701116
Autor:
Todd Macklin, Philip LoGrasso, Valer Jeso, Glenn C. Micalizio, Subhas Chandra Pan, Lisa Cherry
Publikováno v:
Organic letters. 13(19)
A convergent synthesis of benzoquinone ansamycin analogs is described that proceeds by a sequence of metallacycle-mediated alkyne–alkyne coupling, followed by site- and stereoselective dihydroxylation and global carbamate formation. These studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bea0ed50c94e769b1cf55f4a4fb615
https://pubmed.ncbi.nlm.nih.gov/21866939
https://pubmed.ncbi.nlm.nih.gov/21866939
Autor:
Maike Becker, Timothy E. Hurst, Todd B. Marder, Andrei S. Batsanov, Todd Macklin, Wolfgang Kügel, Jean‐Christophe Parisienne‐La Salle, Victor Snieckus, Eduard Hartmann
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 16(27)
Systematic studies are presented demonstrating the complementarity of directed ortho metalation (DoM) and Ir-catalyzed strategies for the provision of borylated aromatics and their subsequent Suzuki-Miyaura coupling reactions. A new concept, the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1b3b038d9bc5a955a28a758bd4f036
https://pubmed.ncbi.nlm.nih.gov/20533457
https://pubmed.ncbi.nlm.nih.gov/20533457
Autor:
Todd Macklin, Glenn C. Micalizio
Publikováno v:
ChemInform. 40
The first total synthesis and structure elucidation of a member of the phorbasin class of natural products is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250bbca1b082c7823fe2a51af2b2664c
https://doi.org/10.1002/chin.200924194
https://doi.org/10.1002/chin.200924194
Autor:
Todd Macklin, Glenn C. Micalizio
Publikováno v:
Journal of the American Chemical Society. 131(4)
The first total synthesis and structure elucidation of a member of the phorbasin class of natural products is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53d3ea917f31ea9fc048e78c13716a3
https://pubmed.ncbi.nlm.nih.gov/19173665
https://pubmed.ncbi.nlm.nih.gov/19173665
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b91f036beb2198b73e76309813620e11
https://doi.org/10.1002/chin.200830133
https://doi.org/10.1002/chin.200830133
Publikováno v:
ChemInform. 38
By using the powerful N-cumylsulfonamide directed metalation group (DMG), a series of 2-substituted derivatives were prepared according to the directed ortho metalation (DoM) tactic (Table 1). Mild conditions for N-decumylation and other simple trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be8ad34f739fec0ebeaf3c7b2881a38
https://doi.org/10.1002/chin.200736070
https://doi.org/10.1002/chin.200736070