Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Todd M. Billeci"'
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Structural effect of complete [Rp]-phosphorothioate and phosphorodithioate substitutions in the DNA strand of a model antisense inhibitor-target RNA complex 1 1Edited by I. Tinoco
Autor: Agnieszka Sierzchala, Wojciech J. Stec, Boleslaw Karwowski, Chojiro Kojima, Alessandro Donati, Thomas L. James, Patrick Furrer, Todd M. Billeci
Publikováno v: Journal of Molecular Biology. 285:1609-1622
Chemically modified DNA oligonucleotides have been crucial to the success of antisense therapeutics. Although such modifications are ubiquitous in the clinic, high-resolution structural studies of pharmaceutically relevant derivatives have been limit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e9e818403efaf6a1ff0bff3f25c9d6
https://doi.org/10.1006/jmbi.1998.2305
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2
Structure of the dimer a initiation complex of HIV-1 genomic RNA
Autor: Anwer Mujeeb, Tristram G. Parslow, Jared L. Clever, Todd M. Billeci, Thomas L. James
Publikováno v: Nature Structural Biology. 5:432-436
Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5a4fbd118c6980140d59fea4dbcd80
https://doi.org/10.1038/nsb0698-432
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3
Analysis of Two-Dimensional Gel Proteins by Mass Spectrometry and Microsequencing
Autor: William J. Henzel, James H. Bourell, Christopher Grimley, Susan C. Wong, Todd M. Billeci, John T. Stults
Publikováno v: Methods. 6:239-247
A method for in situ digestion that allows high recovery of peptides at the low picomole level from two-dimensional gel electroblotted proteins is described. Peptides obtained from in situ digests were analyzed by matrix-assisted laser desorption/ io
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::138a25a2728bca89389bbf915cda1bc5
https://doi.org/10.1006/meth.1994.1026
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4
Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases
Autor: John T. Stults, Christopher Grimley, Susan C. Wong, Todd M. Billeci, William J. Henzel, Colin K. Watanabe
Publikováno v: Proceedings of the National Academy of Sciences. 90:5011-5015
A rapid method for the identification of known proteins separated by two-dimensional gel electrophoresis is described in which molecular masses of peptide fragments are used to search a protein sequence database. The peptides are generated by in situ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81231f02ab8b6c000f9e02f0263037d6
https://doi.org/10.1073/pnas.90.11.5011
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7
Identification of 2-D Gel Proteins at the Femtomole Level by Molecular Mass Searching of Peptide Fragments in a Protein Sequence Database
Autor: Christopher Grimley, William J. Henzel, Susan C. Wong, Todd M. Billeci, John T. Stults, Colin K. Watanabe
Publisher Summary This chapter describes the identification of 2D gel proteins at the femtomole level by molecular mass searching of peptide fragments in a protein sequence database. In a study described in the chapter, single 2D gel spots were excis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e85c43255f28dbf7063edf2d0644b86
https://doi.org/10.1016/b978-0-12-194710-1.50006-0
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8
Tryptic mapping of recombinant proteins by matrix-assisted laser desorption/ionization mass spectrometry
Autor: Todd M. Billeci, John T. Stults
Publikováno v: Analytical chemistry. 65(13)
Various matrix mixtures have been used for matrix-assisted laser desorption/ionization mass spectrometry to characterize the tryptic maps of recombinant human growth hormone (rhGH) and recombinant human tissue plasminogen activator (rt-PA). Carbohydr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a1b9299b1bc0fdffadafd826f7559f
https://pubmed.ncbi.nlm.nih.gov/8368524
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9
Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition?
Autor: Nikolai B. Ulyanov, Todd M. Billeci, Boleslaw Karwowski, Wojciech J. Stec, Marco Tonelli, Piotr Guga, Thomas L. James
Publikováno v: Biophysical Journal. (4):2525-2538
Chemically modified DNA oligonucleotides have been crucial to the development of antisense therapeutics. High-resolution structural studies of pharmaceutically relevant derivatives have been limited to only a few molecules. We have used NMR to elucid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7153991ceba47f89cc117b6a7268bf24
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