Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Todd M. Baughman"'
Autor:
Zhiping Xiong, Jeffrey J. Pouliot, Daniel J. Price, Andrew Maynard, Dulce Garrido, Andrew J. Peat, Katrina L. Creech, Todd M. Baughman, John W. Seal, Vincent W.-F. Tai, Luz Helena Kryn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2288-2294
Two novel series of spirocyclic piperidine analogs appended to a pyrazolo[1,5-a]pyridine core were designed, synthesized and evaluated for their anti-HCV activity. A series of piperidine ketals afforded dispiro 6p which showed excellent in vitro anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424219e5b2990e6eda6f14da635fe535
https://doi.org/10.1016/j.bmcl.2014.03.080
https://doi.org/10.1016/j.bmcl.2014.03.080
Autor:
Emile J. Velthuisen, Todd M. Baughman, Brian A. Johns, David P. Temelkoff, Jason G. Weatherhead
Publikováno v:
European Journal of Medicinal Chemistry. 63:202-212
Several highly deuterated analogs of the HIV-1 protease inhibitor brecanavir have been prepared to study the effect of deuterium upon metabolic stability. The sites for deuterium incorporation were initially chosen to maximize the potential for a kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde19bdf8d4f57e51906010406251085
https://doi.org/10.1016/j.ejmech.2013.02.001
https://doi.org/10.1016/j.ejmech.2013.02.001
Publikováno v:
Rapid Communications in Mass Spectrometry. 23:2146-2150
Propranolol is a widely used quality control and validation compound for liver microsome and hepatocyte metabolism studies. A multitude of literature reports describing the identification of propranolol metabolites exists today. However, no literatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a55082cb3f8b43a627be9cdbab0e7c9
https://doi.org/10.1002/rcm.4130
https://doi.org/10.1002/rcm.4130
Autor:
Robert J. Barnaby, Cosette J. Serabjit-Singh, Luigina Bertolotti, Joseph W. Polli, Todd M. Baughman, Joan E. Humphreys, Angela L. Mote, Giovanni Vitulli, Kevin D. Read, Lindsey O. Webster, Kelly H. Jordan
Publikováno v:
Drug Metabolism and Disposition. 32:722-726
This article is available online at http://dmd.aspetjournals.org ABSTRACT: GV196771 (E-4,6-dichloro-3-(2-oxo-1-phenyl-pyrrolidin-3-glyden- emethyl)-1H-indole-2 carboxylic acid) is a potent antagonist of the modulatory glycine site of the N-methyl-D-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c45942d2fe954230dcbcd882f0391e
https://doi.org/10.1124/dmd.32.7.722
https://doi.org/10.1124/dmd.32.7.722
Autor:
Jo A. Salisbury, Joan E. Humphreys, Cosette J. Serabjit-Singh, Todd M. Baughman, Timothy K. Tippin, Kelly H. Jordan, Joseph W. Polli, Angela L. Mote
Publikováno v:
Journal of Pharmaceutical Sciences. 92:2082-2089
Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating (second-generation) antihistamines. The purpose of this study was to determine the importance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5448bc4ec1f72563033849add475017
https://doi.org/10.1002/jps.10453
https://doi.org/10.1002/jps.10453
Publikováno v:
Rapid communications in mass spectrometry : RCM. 23(14)
Propranolol is a widely used quality control and validation compound for liver microsome and hepatocyte metabolism studies. A multitude of literature reports describing the identification of propranolol metabolites exists today. However, no literatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd338e205429ccd8288655324ac41182
https://pubmed.ncbi.nlm.nih.gov/19517456
https://pubmed.ncbi.nlm.nih.gov/19517456
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 852(1-2)
A hydrophilic interaction chromatography (HILIC)/mass spectrometric assay was developed for the determination of zanamivir, a neuraminidase inhibitor used to treat influenza, in rat and monkey plasma. An organic solvent with hydrophilic properties, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90a1e2341b012921d4414baad02d139
https://pubmed.ncbi.nlm.nih.gov/17324643
https://pubmed.ncbi.nlm.nih.gov/17324643
Autor:
L. O. Tyler, Z. Zhao, M. Wells-Knecht, R. A. Graham, I. S. Silver, Todd M. Baughman, K. Wells-Knecht
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(6)
Pioglitazone is in the class of compounds known as the thiazolidinediones and is used to treat type 2 diabetes mellitus. The first in its class compound, troglitazone, was withdrawn from the U.S. market in 2000 due to a high incidence of hepatotoxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5644540a64e2af3af103fc43861b055d
https://pubmed.ncbi.nlm.nih.gov/15764718
https://pubmed.ncbi.nlm.nih.gov/15764718
Autor:
William F. Elmquist, Jin Cao, William J. Ehlhardt, Bryan H. Norman, Anne H. Dantzig, Michael Gregory Bell, Chuan Shih, James J. Starling, Joseph Michael Gruber, Todd M. Baughman, Mark A. Winter, Kevin L. Law, Julian Stanley Kroin, Robert L. Shepard
Publikováno v:
Advances in enzyme regulation. 37
The above data indicate that LY335979 displays the following characteristics of an 'ideal modulator' of Pgp-mediated multidrug resistance: high affinity binding to Pgp, high potency for in vitro reversal of drug resistance, high therapeutic index (ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1042e4150d8fab86c54d18a1ee4e30
https://pubmed.ncbi.nlm.nih.gov/9381979
https://pubmed.ncbi.nlm.nih.gov/9381979
Publikováno v:
Chemosphere. 31(2)
The urinary metabolites of n-nonane in male Fischer 344 rats, after administering the hydrocarbon by gavage, included gamma-valerolactone, delta-hexanolactone, 2,5-hexanedione, delta-heptanolactone, 1-heptanol, 2-nonanol, 3-nonanol, 4-nonanol, 4-nona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2920a80b899453fbbe6bb6208df649
https://pubmed.ncbi.nlm.nih.gov/7663950
https://pubmed.ncbi.nlm.nih.gov/7663950