Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Todd M Umstead"'
Autor:
Nikolaos Tsotakos, Imtiaz Ahmed, Todd M Umstead, Yuka Imamura, Eric Yau, Patricia Silveyra, Zissis C Chroneos
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272769 (2022)
IntroductionDespite recent advances in perinatal medicine, bronchopulmonary dysplasia (BPD) remains the most common complication of preterm birth. Inflammation, the main cause for BPD, results in arrested alveolarization. All trans-retinoic acid (ATR
Externí odkaz:
https://doaj.org/article/e0dc293142ae492a82cc89fd1be1150a
Autor:
Linlin Yang, Marykate Carrillo, Yuchieh M Wu, Susan L DiAngelo, Patricia Silveyra, Todd M Umstead, E Scott Halstead, Michael L Davies, Sanmei Hu, Joanna Floros, Francis X McCormack, Neil D Christensen, Zissis C Chroneos
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126576 (2015)
The surfactant protein (SP-A) receptor SP-R210 has been shown to increase phagocytosis of SP-A-bound pathogens and to modulate cytokine secretion by immune cells. SP-A plays an important role in pulmonary immunity by enhancing opsonization and cleara
Externí odkaz:
https://doaj.org/article/6cc79ebc817a4781bc32ac91d56ed8e6
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1309 (2024)
Bronchopulmonary dysplasia (BPD) is a condition of poor alveolar formation that causes chronic breathing impairment in infants born prematurely. Preterm lungs lack surfactant and are vulnerable to oxidative injuries driving the development of BPD. Ou
Externí odkaz:
https://doaj.org/article/7c1978b28bc849768fca8cef91da6e2d
Autor:
Eric Yau, Linlin Yang, Yan Chen, Todd M. Umstead, Hannah Atkins, Zoe E. Katz, Jonathan W. Yewdell, Chintan K. Gandhi, E. Scott Halstead, Zissis C. Chroneos
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Influenza A virus infection (IAV) often leads to acute lung injury that impairs breathing and can lead to death, with disproportionate mortality in children and the elderly. Surfactant Protein A (SP-A) is a calcium-dependent opsonin that binds a vari
Externí odkaz:
https://doaj.org/article/ee1c29f7544b428881aed0e21bc94850
Autor:
Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps, Joanna Floros
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, encoding SP-A1 and SP-A2
Externí odkaz:
https://doaj.org/article/a706419cdf7a4e0d9a0d4e3e664fa943
Autor:
E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Kurundu Hewage, Zissis C. Chroneos
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Influenza A viruses cause life-threatening pneumonia and lung injury in the lower respiratory tract. Application of high GM-CSF levels prior to infection has been shown to reduce morbidity and mortality from pathogenic influenza i
Externí odkaz:
https://doaj.org/article/02b87ee4fa9e4f2b8a3976e638c9ec51
Autor:
George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Publikováno v:
Biology of Sex Differences, Vol 8, Iss 1, Pp 1-15 (2017)
Abstract Background Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome.
Externí odkaz:
https://doaj.org/article/43743536d5db48219524e748ebe2bae6
Autor:
Kristin K. Fino, Linlin Yang, Patricia Silveyra, Sanmei Hu, Todd M. Umstead, Susan DiAngelo, E. Scott Halstead, Timothy K. Cooper, Thomas Abraham, Yoshinori Takahashi, Zhixiang Zhou, Hong Gang Wang, Zissis C. Chroneos
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract New influenza A viruses that emerge frequently elicit composite inflammatory responses to both infection and structural damage of alveolar-capillary barrier cells that hinders regeneration of respiratory function. The host factors that relin
Externí odkaz:
https://doaj.org/article/9f2db467b2f24fcdb539803d205c307c
Autor:
Armen Nalian, Todd M. Umstead, Ching-Hui Yang, Patricia Silveyra, Neal J. Thomas, Joanna Floros, Francis X. McCormack, Zissis C. Chroneos
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Surfactant protein A (SP-A) provides surfactant stability, first line host defense, and lung homeostasis by binding surfactant phospholipids, pathogens, alveolar macrophages (AMs), and epithelial cells. Non-primates express one SP-A protein whereas h
Externí odkaz:
https://doaj.org/article/dfef1749e33a476898eb6f07da97fd9c
Autor:
George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pulmonary surfactant protein A (SP-A) plays an important role in surfactant metabolism and lung innate immunity. In humans there are two proteins, SP-A1 and SP-A2, encoded by SFTPA1 and SFTPA2, respectively, which are produced by the alveolar type II
Externí odkaz:
https://doaj.org/article/baf9ea18eb9b40de9698f3cbd1ab1faf