Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Todd M, Lowe"'
Autor:
Josephine Davey-Young, Farah Hasan, Rasangi Tennakoon, Peter Rozik, Henry Moore, Peter Hall, Ecaterina Cozma, Julie Genereaux, Kyle S. Hoffman, Patricia P. Chan, Todd M. Lowe, Christopher J. Brandl, Patrick O’Donoghue
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-23 (2024)
ABSTRACTTranslation fidelity relies on accurate aminoacylation of transfer RNAs (tRNAs) by aminoacyl-tRNA synthetases (AARSs). AARSs specific for alanine (Ala), leucine (Leu), serine, and pyrrolysine do not recognize the anticodon bases. Single nucle
Externí odkaz:
https://doaj.org/article/b5dfad6187bd4976a2eaefb2e55ed373
Autor:
Blake A. Sweeney, David Hoksza, Eric P. Nawrocki, Carlos Eduardo Ribas, Fábio Madeira, Jamie J. Cannone, Robin Gutell, Aparna Maddala, Caeden D. Meade, Loren Dean Williams, Anton S. Petrov, Patricia P. Chan, Todd M. Lowe, Robert D. Finn, Anton I. Petrov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Non-coding RNA function is poorly understood, partly due to the challenge of determining RNA secondary (2D) structure. Here, the authors present a framework for the reproducible prediction and visualization of the 2D structure of a wide array of RNAs
Externí odkaz:
https://doaj.org/article/08c55853e54b4060954e1a43ffedc3a6
Autor:
Guoping Li, Aidan C. Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P. Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D. Laurent, Sary F. Aranki, Maria I. Kontaridis, Louise C. Laurent, Kendall Van Keuren‐Jensen, Jochen Muehlschlegel, Todd M. Lowe, Saumya Das
Publikováno v:
Advanced Science, Vol 9, Iss 17, Pp n/a-n/a (2022)
Abstract The cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may identify novel biomarkers and key signaling pathways for different diseases. Emerging
Externí odkaz:
https://doaj.org/article/1c604b8983c147c197c8d6c4daa9b57a
Autor:
Andrew D. Holmes, Patricia P. Chan, Qi Chen, Pavel Ivanov, Laurence Drouard, Norbert Polacek, Mark A. Kay, Todd M. Lowe
Small RNAs processed from transfer RNA are recognized to have regulatory functions distinct from protein synthesis. This rapidly advancing field has led to a constellation of transcript nomenclatures. Building upon the accepted tRNA naming system and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514e57aea0374e987516be0130b4fee8
Recent high-throughput sequencing protocols have facilitated increased accuracy in measurements of transfer tRNAs (tRNAs) and tRNA-derived small RNAs (tDRs) from biological samples. However, commonly used RNA-seq analysis pipelines overlook special c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e83959e2ac3b7ba0fb2b12127469fe1
https://doi.org/10.1101/2022.07.02.498565
https://doi.org/10.1101/2022.07.02.498565
Publikováno v:
Nucleic acids research. 50(7)
Metazoan organisms have many tRNA genes responsible for decoding amino acids. The set of all tRNA genes can be grouped in sets of common amino acids and isoacceptor tRNAs that are aminoacylated by corresponding aminoacyl-tRNA synthetases. Analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c37f5ea014bff4265a5d5e2f06fcbe
https://pubmed.ncbi.nlm.nih.gov/35380696
https://pubmed.ncbi.nlm.nih.gov/35380696
Publikováno v:
microPublication biology. 2022
Transfer RNAs (tRNAs) are ubiquitous adapter molecules that link specific codons in messenger RNA (mRNA) with their corresponding amino acids during protein synthesis. The tRNA genes of Drosophila have been investigated for over half a century but ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4c9fd026a77b2a71769f63d97749097
https://pubmed.ncbi.nlm.nih.gov/35789696
https://pubmed.ncbi.nlm.nih.gov/35789696
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134738 (2015)
The rat kangaroo (long-nosed potoroo, Potorous tridactylus) is a marsupial native to Australia. Cultured rat kangaroo kidney epithelial cells (PtK) are commonly used to study cell biological processes. These mammalian cells are large, adherent, and f
Externí odkaz:
https://doaj.org/article/9d7ac074267f409d96d0d16a94d11167
Autor:
Brice D. Laurent, Haobo Li, Robert R. Kitchen, Aidan Manning, Maria I. Kontaridis, Alex Bagi, Todd M. Lowe, Xinyu Yang, Guoping Li, Jonathan M. Howard, Jochen D. Muehlschlegel, Thadryan Sweeney, Saumya Das, Patricia P. Chan, Louise C. Laurent, Kendall Van Keuren Jensen, Sary F. Aranki
SUMMARYThe cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may yield novel biomarkers for different diseases, and potentially identify key signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4c3a274f176c12c1b8e37a8a6f7252
https://doi.org/10.1101/2021.09.03.458085
https://doi.org/10.1101/2021.09.03.458085
Autor:
Haobo Li, Priyanka Gokulnath, Guoping Li, Alex Bagi, Robert R. Kitchen, Michail Spanos, Saumya Das, Manning Aidan, Jochen D. Muehlschlegel, Todd M. Lowe
Publikováno v:
Circulation Research. 129
Heart failure (HF) remains the leading cause of morbidity and mortality in the US, affecting approximately 6.2 million Americans with an anticipated 46% increase in overall prevalence by 2030. Myocardial fibrosis, defined as increased cardiac fibrobl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23ac8c82226e547f889113ed05383bd2
https://doi.org/10.1161/res.129.suppl_1.p384
https://doi.org/10.1161/res.129.suppl_1.p384