Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Todd M, Brusko"'
Autor:
Andrew Goetz, Joy Cagmat, Maigan Brusko, Todd M. Brusko, Anna Rushin, Matthew Merritt, Timothy Garrett, Laurence Morel, Purushottam Dixit
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Impaired metabolism is recognized as an important contributor to pathogenicity of T cells in Systemic Lupus Erythematosus (SLE). Over the last two decades, we have acquired significant knowledge about the signaling and transcriptomic programs related
Externí odkaz:
https://doaj.org/article/a5c51b4a99d641349a10886d7d5841bb
Autor:
Evan L. Barrios, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Micah Willis, Valerie E. Polcz, Gwendolyn S. Gillies, Jennifer A. Munley, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie-Pierre L. Gauthier, Shawn D. Larson, Laurence Morel, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Michael P. Kladde, Clayton E. Mathews, Maigan A. Brusko, Todd M. Brusko, Lyle L. Moldawer, Rhonda Bacher, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who devel
Externí odkaz:
https://doaj.org/article/c3d9f1e91fd841aa9fdb8d5f4c7a4bf1
Autor:
Daniel J. Perry, Melanie R. Shapiro, Sonya W. Chamberlain, Irina Kusmartseva, Srikar Chamala, Leandro Balzano-Nogueira, Mingder Yang, Jason O. Brant, Maigan Brusko, MacKenzie D. Williams, Kieran M. McGrail, James McNichols, Leeana D. Peters, Amanda L. Posgai, John S. Kaddis, Clayton E. Mathews, Clive H. Wasserfall, Bobbie-Jo M. Webb-Robertson, Martha Campbell-Thompson, Desmond Schatz, Carmella Evans-Molina, Alberto Pugliese, Patrick Concannon, Mark S. Anderson, Michael S. German, Chester E. Chamberlain, Mark A. Atkinson, Todd M. Brusko
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-16 (2023)
Abstract The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-re
Externí odkaz:
https://doaj.org/article/0ad4cb66140840c5abd02c69201bad7b
Autor:
Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, Puchong Thirawatananond, Amanda L. Posgai, Leeana D. Peters, Keshav Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, Clive H. Wasserfall, Michael J. Haller, Desmond A. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda Bacher, Todd M. Brusko
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
The proportions and phenotypes of immune cell subsets in peripheral blood undergo continual and dramatic remodeling throughout the human life span, which complicates efforts to identify disease-associated immune signatures in type 1 diabetes (T1D). W
Externí odkaz:
https://doaj.org/article/637333e5554a47dcb1444963f6436280
Autor:
Laura M. Jacobsen, Kirsten Diggins, Lori Blanchfield, James McNichols, Daniel J. Perry, Jason Brant, Xiaoru Dong, Rhonda Bacher, Vivian H. Gersuk, Desmond A. Schatz, Mark A. Atkinson, Clayton E. Mathews, Michael J. Haller, S. Alice Long, Peter S. Linsley, Todd M. Brusko
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
BACKGROUND Low-dose anti–thymocyte globulin (ATG) transiently preserves C-peptide and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the mechanisms of action and features of the response remain unclear. Here, we chara
Externí odkaz:
https://doaj.org/article/ad46bb6a2d254bafb3f6b3213915a443
Autor:
Faheem W. Guirgis, MD, Vinitha Jacob, MD, PhD, Dongyuan Wu, MS, Morgan Henson, MPH, Kimberly Daly-Crews, BS, MS, Charlotte Hopson, MS, Lauren Page Black, MD, MPH, Elizabeth L. DeVos, MD, MPH, Dawoud Sulaiman, PhD, Guillaume Labilloy, MS, Todd M. Brusko, PhD, Jordan A. Shavit, MD, PhD, Andrew Bertrand, BS, Matthew Feldhammer, PhD, Brett Baskovich, MD, Kiley Graim, PhD, Susmita Datta, PhD, Srinivasa T. Reddy, PhD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 6, p e0929 (2023)
IMPORTANCE:. This is a study of lipid metabolic gene expression patterns to discover precision medicine for sepsis. OBJECTIVES:. Sepsis patients experience poor outcomes including chronic critical illness (CCI) or early death (within 14 d). We invest
Externí odkaz:
https://doaj.org/article/fd6d22cc5aab4a2aa1801b53b447a5a7
Autor:
Leeana D. Peters, Wen-I Yeh, Juan M. Arnoletti, Matthew E. Brown, Amanda L. Posgai, Clayton E. Mathews, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The autoimmune pathogenesis of type 1 diabetes (T1D) involves cellular infiltration from innate and adaptive immune subsets into the islets of Langerhans within the pancreas; however, the direct cytotoxic killing of insulin-producing β-cells is thou
Externí odkaz:
https://doaj.org/article/84a0c1b62a9c4bd1bd78d647cf57931b
Autor:
Faheem W. Guirgis, Lauren Page Black, Morgan Henson, Guillaume Labilloy, Carmen Smotherman, Charlotte Hopson, Ian Tfirn, Elizabeth L. DeVos, Christiaan Leeuwenburgh, Lyle Moldawer, Susmita Datta, Todd M. Brusko, Alexis Hester, Andrew Bertrand, Victor Grijalva, Alexander Arango-Esterhay, Frederick A. Moore, Srinivasa T. Reddy
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-13 (2021)
Abstract Objective Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We sought to characterize lip
Externí odkaz:
https://doaj.org/article/1e18141fd01c4b3c9ea095a3c4c7850e
Autor:
Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, Christopher A. Fuhrman, Amanda L. Posgai, Melanie R. Shapiro, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Regulatory T cell (Treg) adoptive cell therapy (ACT) represents an emerging strategy for restoring immune tolerance in autoimmune diseases. Tregs are commonly purified using a CD4+CD25+CD127lo/- gating strategy, which yields a mixed population: 1) ce
Externí odkaz:
https://doaj.org/article/ee8774329b694e21a6e707bc96062b84
Autor:
Peter S. Linsley, Fariba Barahmand-pour-Whitman, Elisa Balmas, Hannah A. DeBerg, Kaitlin J. Flynn, Alex K. Hu, Mario G. Rosasco, Janice Chen, Colin O’Rourke, Elisavet Serti, Vivian H. Gersuk, Keshav Motwani, Howard R. Seay, Todd M. Brusko, William W. Kwok, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom, Karen Cerosaletti
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to identify T cell receptors (TCRs) in IAR T cells, we have identifie
Externí odkaz:
https://doaj.org/article/ae78e844c0644847af1e433a33d6fd7d