Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Todd Lamitina"'
Autor:
Sarel J. Urso, Todd Lamitina
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss S1, Pp 89-105 (2021)
Externí odkaz:
https://doaj.org/article/e2cfefceb95e4956ba338fef85896d9e
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1008821 (2020)
The conserved O-GlcNAc transferase OGT O-GlcNAcylates serine and threonine residues of intracellular proteins to regulate their function. OGT is required for viability in mammalian cells, but its specific roles in cellular physiology are poorly under
Externí odkaz:
https://doaj.org/article/3fa1c93e13fa43c99537f5a94d3edc83
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0227464 (2020)
Expanded CAG nucleotide repeats are the underlying genetic cause of at least 14 incurable diseases, including Huntington's disease (HD). The toxicity associated with many CAG repeat expansions is thought to be due to the translation of the CAG repeat
Externí odkaz:
https://doaj.org/article/d01f2947497a40cd8ff13e8c91e481e0
Autor:
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007038 (2017)
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding w
Externí odkaz:
https://doaj.org/article/944a8ce4a5f7455e8e44dd3caf07d459
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 930-939 (2012)
SUMMARY Membrane proteins make up ∼30% of the proteome. During the early stages of maturation, this class of proteins can experience localized misfolding in distinct cellular compartments, such as the cytoplasm, endoplasmic reticulum (ER) lumen and
Externí odkaz:
https://doaj.org/article/3e1fb6dfa21341d4bcaf429eb617d780
Autor:
Fan Li, Qi Zheng, Paul Ryvkin, Isabelle Dragomir, Yaanik Desai, Subhadra Aiyer, Otto Valladares, Jamie Yang, Shelly Bambina, Leah R. Sabin, John I. Murray, Todd Lamitina, Arjun Raj, Sara Cherry, Li-San Wang, Brian D. Gregory
Publikováno v:
Cell Reports, Vol 1, Iss 1, Pp 69-82 (2012)
The secondary structure of RNA is necessary for its maturation, regulation, processing, and function. However, the global influence of RNA folding in eukaryotes is still unclear. Here, we use a high-throughput, sequencing-based, structure-mapping app
Externí odkaz:
https://doaj.org/article/d59b119879334ef1bb27190d6fec6621
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33494 (2012)
The DAF-2 Insulin/IGF-1 signaling (IIS) pathway is a strong modifier of Caenorhabditis elegans longevity and healthspan. As aging is the greatest risk factor for developing neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), we we
Externí odkaz:
https://doaj.org/article/6b3e7bc7dbad4117acbf0db2c0440777
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001267 (2011)
The molecular mechanisms of animal cell osmoregulation are poorly understood. Genetic studies of osmoregulation in yeast have identified mucin-like proteins as critical regulators of osmosensitive signaling and gene expression. Whether mucins play si
Externí odkaz:
https://doaj.org/article/e2014672d5fe4a06a31f914fc1dbccea
Autor:
Elizabeth Morton, Todd Lamitina
Publikováno v:
BioTechniques, Vol 48, Iss 6, Pp xxv-xxx (2010)
Complex Object Parametric Analyzer and Sorter (COPAS) devices are large-object, fluorescence-capable flow cytometers used for high-throughput analysis of live model organisms, including Drosophila melanogaster, Caenorhabditis elegans, and zebrafish.
Externí odkaz:
https://doaj.org/article/645d1fd217654d94a6fe6a1918e1c176
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9010 (2010)
The soil-dwelling nematode C. elegans is a powerful system for comparative molecular analyses of environmental stress response mechanisms. Infection of worms with bacterial and fungal pathogens causes the activation of well-characterized innate immun
Externí odkaz:
https://doaj.org/article/e3142e04edc2454993c8ca70fa7e6396