Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Todd L. Lowary"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The bacterial genus Salmonella includes diverse isolates with multiple variations in the structure of the main polysaccharide component (O antigen) of membrane lipopolysaccharides. In addition, some isolates produce a transient (T) antigen,
Externí odkaz:
https://doaj.org/article/9fb38d483ced4033887e62f319bb94df
Autor:
Chih-Lan Lin, Mirat Sojitra, Eric J. Carpenter, Ellen S. Hayhoe, Susmita Sarkar, Elizabeth A. Volker, Chao Wang, Duong T. Bui, Loretta Yang, John S. Klassen, Peng Wu, Matthew S. Macauley, Todd L. Lowary, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cellular glycosylation is characterized by chemical complexity and heterogeneity, which is challenging to reproduce synthetically. Here we show chemoenzymatic synthesis on phage to produce a genetically-encoded liquid glycan array (LiGA) of
Externí odkaz:
https://doaj.org/article/da21baab0c17465c9c943d4e2e9add04
Autor:
Elise Ishida, Devin T. Corrigan, Tingting Chen, Yanyan Liu, Ryung S. Kim, Lusheng Song, Tara M. Rutledge, D Mitchell Magee, Joshua LaBaer, Todd L. Lowary, Philana Ling Lin, Jacqueline M. Achkar
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104897- (2024)
Summary: Background: Increasing evidence supports that antibodies can protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially in the airways, is limited. The main objective of this study was to identify a
Externí odkaz:
https://doaj.org/article/4a9a42baaad14733a7cf3cdf00f2652e
Autor:
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Throug
Externí odkaz:
https://doaj.org/article/1b849c2f9a814c4e9507f12b5f5f0d43
Autor:
Yanyan Liu, Tingting Chen, Yongqi Zhu, Aisha Furey, Todd L. Lowary, John Chan, Stylianos Bournazos, Jeffrey V. Ravetch, Jacqueline M. Achkar
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
A better understanding of the epitopes most relevant for antibody-mediated protection against tuberculosis (TB) remains a major knowledge gap. We have shown that human polyclonal IgG against the Mycobacterium tuberculosis (M. tuberculosis) surface gl
Externí odkaz:
https://doaj.org/article/ad99af55a6404c3db7398407cdf3e82f
Autor:
Taylor J. B. Forrester, Olga G. Ovchinnikova, Zhixiong Li, Elena N. Kitova, Jeremy T. Nothof, Akihiko Koizumi, John S. Klassen, Todd L. Lowary, Chris Whitfield, Matthew S. Kimber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
WbbB is a structurally unusual retaining glycosyltransferase. Here, the authors show that WbbB forms an Asp232-Kdo adduct prior to transfer to the saccharide acceptor. Therefore, unlike any previously studied glycosyltransferase, WbbB uses the double
Externí odkaz:
https://doaj.org/article/2fa33b5bdb8243bf8c1fb3e07ccfe81c
Autor:
Elise Ishida, Devin T. Corrigan, Ryan J. Malonis, Daniel Hofmann, Tingting Chen, Anita G. Amin, Delphi Chatterjee, Maju Joe, Todd L. Lowary, Jonathan R. Lai, Jacqueline M. Achkar
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Elise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis. The authors dem
Externí odkaz:
https://doaj.org/article/beed135280764d7ba72204f728213be0
Autor:
Yong Zi Tan, José Rodrigues, James E. Keener, Ruixiang Blake Zheng, Richard Brunton, Brian Kloss, Sabrina I. Giacometti, Ana L. Rosário, Lei Zhang, Michael Niederweis, Oliver B. Clarke, Todd L. Lowary, Michael T. Marty, Margarida Archer, Clinton S. Potter, Bridget Carragher, Filippo Mancia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase B EmbB involved in mycobacterial cell wall biosynthesis provides insights into the substrate binding and reaction mechanism. Mapping of the ethambutol resistance associated mutati
Externí odkaz:
https://doaj.org/article/eeb46691fab54cb4aea7d475e6b51125
Autor:
Taylor J. B. Forrester, Olga G. Ovchinnikova, Zhixiong Li, Elena N. Kitova, Jeremy T. Nothof, Akihiko Koizumi, John S. Klassen, Todd L. Lowary, Chris Whitfield, Matthew S. Kimber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/70513d97c9e147d892c0109832b3dc52
Autor:
Monika Jankute, Luke J. Alderwick, Alice R. Moorey, Maju Joe, Sudagar S. Gurcha, Lothar Eggeling, Todd L. Lowary, Anne Dell, Poh-Choo Pang, Tiandi Yang, Stuart Haslam, Gurdyal S. Besra
Publikováno v:
The Cell Surface, Vol 2, Iss , Pp 38-53 (2018)
The arabinan-containing polysaccharides, arabinogalactan (AG) and lipoarabinomannan (LAM), are key cell wall components of the Corynebacterineae, which include Corynebacteria, Norcadia and Mycobacteria. Both AG and LAM contain elaborate arabinan doma
Externí odkaz:
https://doaj.org/article/878dde211947413aaeecc3de06b0131f