A phase 2 randomized, double-blind, placebo-controlled study of the effect of VIA-2291, a 5-lipoxygenase inhibitor, on vascular inflammation in patients after an acute coronary syndrome

Autor: Venkatesh Mani, Tilmann M. Brotz, James H.F. Rudd, Rebecca Taub, Michael E. Farkouh, Jean-Claude Tardif, Ahmed Tawakol, David Rosenbaum, Juan Gaztanaga, Zahi A. Fayad, Todd Kerwin

Publikováno v: Atherosclerosis. 240:53-60

Arachidonate 5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes. VIA-2291 is a potent 5-LO inhibitor, which has been shown to reduce hsCRP and noncalcified coronary plaque volume following an acute coronary syndrome (ACS). We aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259c6abdf94541d856e108bc28f1dcbd
https://doi.org/10.1016/j.atherosclerosis.2015.02.027

Impact of transesophageal echocardiography on clinical management of patients over age 50 with cryptogenic stroke and normal transthoracic echocardiogram

Autor: Seth Goldbarg, Brian Marino, Gary L. Bernardini, Abhishek Jaiswal, Todd Kerwin

Publikováno v: Journal of hospital medicine. 11(2)

BACKGROUND The utility of transesophageal echocardiography (TEE) subsequent to a normal transthoracic echocardiogram (TTE) in older patients with an unexplained stroke is uncertain. METHODS Two hundred sixty-three consecutive patients over the age of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2fdf1051836102d3e56ff25b67eb89
https://pubmed.ncbi.nlm.nih.gov/26390115

Abstract 68: A Cardiologist-Directed, Selective Testing Approach to Emergency Department Chest Pain Patients is Safe and Efficient

Autor: Pratik Panchal, Harmony Leighton, Jennifer Kostela, Jesse Rizkalla, Mark Balek, Katherine Heretis, Todd Kerwin

Publikováno v: Circulation: Cardiovascular Quality and Outcomes. 6

Background: A protocol driven, non-selective approach to low to intermediate risk patients with chest pain (CP) in the Emergency Department (ED) usually consists of a period of observation followed by a noninvasive test, with cardiology consultation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6adb3ac0063008ab12ef9498b3d055a
https://doi.org/10.1161/circoutcomes.6.suppl_1.a68

Incidence and prognosis of pacemaker lead-associated masses: a study of 1,569 transesophageal echocardiograms

Autor: Ronald, Lo, Michael, D'Anca, Todd, Cohen, Todd, Kerwin

Publikováno v: The Journal of invasive cardiology. 18(12)

Endovascular lead infection is an uncommon but serious problem. Transesophageal echocardiography (TEE) is a useful tool for identification of pacemaker lead vegetations. Additionally, incidental echogenic masses are occasionally identified by TEE. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94ed20c19cb7be72579c64fb604fa3f3
https://pubmed.ncbi.nlm.nih.gov/17197711

Partitioning of pyruvate between oxidation and anaplerosis in swine hearts

Autor: Todd Kerwin, Hazel Huang, William C. Stanley, Henri Brunengraber, Ahmed Darvish, Blandine Comte, Christine Des Rosiers, Ashish R. Panchal

Publikováno v: AJP-Heart and Circulatory Physiology
AJP-Heart and Circulatory Physiology, American Physiological Society, 2000, 279 (5), pp.H2390-H2398. ⟨10.1152/ajpheart.2000.279.5.H2390⟩

The goal of this study was to measure flux through pyruvate carboxylation and decarboxylation in the heart in vivo. These rates were measured in the anterior wall of normal anesthetized swine hearts by infusing [U-13C3]lactate and/or [U-13C3] pyruvat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a0666a6c238369d528fe527a6d991f
https://hal.inrae.fr/hal-03324913