Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Todd J Cohen"'
Autor:
Connor M Wander, Ya-Dong Li, Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen, Juan Song
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Alzheimer’s disease (AD) is characterized by a progressive loss of memory that cannot be efficiently managed by currently available AD therapeutics. So far, most treatments for AD that have the potential to improve memory target
Externí odkaz:
https://doaj.org/article/b86bc6cf52144cdf81b7f50dbae489f8
Autor:
Julie C Necarsulmer, Jeremy M Simon, Baggio A Evangelista, Youjun Chen, Xu Tian, Sara Nafees, Ariana B Marquez, Huijun Jiang, Ping Wang, Deepa Ajit, Viktoriya D Nikolova, Kathryn M Harper, J Ashley Ezzell, Feng-Chang Lin, Adriana S Beltran, Sheryl S Moy, Todd J Cohen
Publikováno v:
eLife, Vol 12 (2023)
TDP-43 proteinopathies including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic acid-binding protein TDP-43 and subseque
Externí odkaz:
https://doaj.org/article/1ef60b65b631406abd7b36cb7384d395
Autor:
Miles R. Bryan III, Xu Tian, Jui-Heng Tseng, Baggio A. Evangelista, Joey V. Ragusa, Audra F. Bryan, Winifred Trotman, David Irwin, Todd J. Cohen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Tauopathies, including Alzheimer’s disease (AD), are a class of neurodegenerative diseases characterized by the presence of insoluble tau inclusions. Tau phosphorylation has traditionally been viewed as the dominant post-translational modi
Externí odkaz:
https://doaj.org/article/a224761b89a941c684570125212d6515
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158470 (2016)
Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer's disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for n
Externí odkaz:
https://doaj.org/article/00304546cd3948d1bab7f982283225c6
Autor:
Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohen
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168913 (2016)
Lysine acetylation has emerged as a dominant post-translational modification (PTM) regulating tau proteins in Alzheimer's disease (AD) and related tauopathies. Mass spectrometry studies indicate that tau acetylation sites cluster within the microtubu
Externí odkaz:
https://doaj.org/article/4fc34fa587d94901880a90f78711b1a7
Autor:
Shenée C. Martin, Kathryn K. Joyce, Kathryn M. Harper, Samuel J. Harp, Todd J. Cohen, Sheryl S. Moy, Graham H. Diering
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 319 (2024)
Sleep disruption is an expected component of aging and neurodegenerative conditions, including Alzheimer’s disease (AD). Sleep disruption has been demonstrated as a driver of AD pathology and cognitive decline. Therefore, treatments designed to mai
Externí odkaz:
https://doaj.org/article/7e26de891f7f48d69a3dc5e4560420ae
Autor:
Connor M. Wander, Tamy Harumy Moraes Tsujimoto, John F. Ervin, Chanung Wang, Spencer M. Maranto, Vanya Bhat, Julian D. Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K. Scott, David M. Holtzman, Todd J. Cohen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste repositories for aggregated proteins, damaged cellular organelles, and other cellular debr
Externí odkaz:
https://doaj.org/article/751400fec6844f3a9a348aeb0cb10d36
Autor:
Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.
Externí odkaz:
https://doaj.org/article/61ab6286279144ac8d59a59cc0805267
Autor:
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101255- (2020)
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species
Externí odkaz:
https://doaj.org/article/4d3bd9a5d99a43c1a2f2a65407b70fe6
Publikováno v:
Journal of Osteopathic Medicine. 122:503-508
Context During the COVID-19 pandemic, essential in-person electrocardiogram (ECG) recordings became unfeasible, while patients continued to suffer from cardiac conditions. To circumvent these challenges, the cardiology clinic (Long Island Heart Rhyth