Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Todd Herbst"'
Autor:
Annalise Di Marco, Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Maria Rosaria Battista, Antonella Cellucci, Elena Bracacel, Giulio Auciello, Maria Veneziano, Vinod Khetarpal, Mark Rose, Alessandro Rosa, Isabelle Gloaguen, Edith Monteagudo, Todd Herbst, Celia Dominguez, Ignacio Muñoz-Sanjuán
Publikováno v:
Cells, Vol 9, Iss 4, p 994 (2020)
The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances, in healthy and diseased states. Stem cell technology offers the o
Externí odkaz:
https://doaj.org/article/d4344a862cc142e2914339bfced09308
Autor:
Longbin Liu, Peter D. Johnson, Michael E. Prime, Vinod Khetarpal, Christopher J. Brown, Luca Anzillotti, Daniele Bertoglio, Xuemei Chen, Samuel Coe, Randall Davis, Anthony P. Dickie, Simone Esposito, Elise Gadouleau, Paul R. Giles, Catherine Greenaway, James Haber, Christer Halldin, Scott Haller, Sarah Hayes, Todd Herbst, Frank Herrmann, Manuela Heßmann, Ming Min Hsai, Yaser Khani, Adrian Kotey, Angelo Lembo, John E. Mangette, Gwendolyn A. Marriner, Richard W. Marston, Matthew R. Mills, Edith Monteagudo, Anton Forsberg-Morén, Sangram Nag, Laura Orsatti, Christine Sandiego, Sabine Schaertl, Joanne Sproston, Steven Staelens, Jack Tookey, Penelope A. Turner, Andrea Vecchi, Maria Veneziano, Ignacio Muñoz-Sanjuan, Jonathan Bard, Celia Dominguez
Publikováno v:
Journal of Medicinal Chemistry. 66:641-656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e78d658107fd1300b7add11eee0911
https://doi.org/10.1021/acs.jmedchem.2c01585
https://doi.org/10.1021/acs.jmedchem.2c01585
Autor:
Vinod Khetarpal, Todd Herbst, Shahzad Akhtar, Amber LaFayette, Dennis Miller, James Farnham, Troy Steege, Zhixin Miao, Bryan Marks, Aaron Ledvina, Celia Dominguez
Publikováno v:
Bioanalysis.
Background: Dysregulation of the kynurenine metabolic pathway has been reported in several neurological conditions. Methods & results: Sensitive and selective LC–MS/MS methods have been validated for six kynurenine pathway metabolites in human cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b0eee84b5a4ab4645745364aa8b17a
https://doi.org/10.4155/bio-2023-0016
https://doi.org/10.4155/bio-2023-0016
Autor:
Vinod Khetarpal, Todd Herbst, Michael E. Fitzsimmons, Celia Dominguez, Diana Shefchek, Mark Gohdes, Steven Ash, Ignacio Munoz-Sanjuan
Publikováno v:
Xenobiotica. 51:1155-1180
The disposition of a novel kynurenine monooxygenase inhibitor, CHDI-340246, was investigated in vitro and in animals.In vitro, there was minimal metabolic turnover of CHDI-340246 in all species. The protein binding was higher in human plasma (99.7%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679ccf3378aebc32cb75ee60712d013b
https://doi.org/10.1080/00498254.2021.1977868
https://doi.org/10.1080/00498254.2021.1977868
Autor:
Vinod Khetarpal, Catherine Greenaway, Samantha Ensor, Randall Davis, Michael Conlon, Andrea Varrone, Frank Herrmann, Laura Orsatti, Xuemei Chen, Martina Nibbio, Christer Halldin, Vladimir Stepanov, Simone Esposito, Daniel Clark-Frew, Ladislav Mrzljak, Christoph Scheich, Sabine Schaertl, Todd Herbst, Ming Min Hsai, Peter Johnson, Samuel Coe, Jonathan Bard, John Wityak, Michael Prime, Katarina Varnäs, Adrian Kotey, Lee Matthew, Sangram Nag, Manuela Heßmann, Celia Dominguez, Samantha Green, James C. Haber, Xinjie Gai, Longbin Liu, Edith Monteagudo, Anton Forsberg Morén, John E. Mangette, Christopher J. Brown, Matthew R. Mills, Ignacio Munoz-Sanjuan, Joanne Sproston, Sarah Hayes
Publikováno v:
Journal of Medicinal Chemistry. 64:12003-12021
The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington's disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66bf0795aa450250464e8592df8acb66
https://doi.org/10.1021/acs.jmedchem.1c00667
https://doi.org/10.1021/acs.jmedchem.1c00667
Autor:
Mark Rose, Odalys Gonzalez Paz, Giulio Auciello, Annalise Di Marco, Todd Herbst, Ignacio Muñoz-Sanjuán, Domenico Vignone, Edith Monteagudo, Vinod Khetarpal, Matteo Zini, Maria Rosaria Battista, Laura Orsatti, Vincenzo Summa, Celia Dominguez, Leticia M Toledo-Sherman, Ivan Fini, Antonella Cellucci
Publikováno v:
Molecular Pharmaceutics. 16:2069-2082
Huntington's disease (HD) is a neurodegenerative disease caused by polyglutamine expansion in the huntingtin protein. For drug candidates targeting HD, the ability to cross the blood-brain barrier (BBB) and reach the site of action in the central ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cfdbc702df6685a64c4f15855675c2
https://doi.org/10.1021/acs.molpharmaceut.9b00042
https://doi.org/10.1021/acs.molpharmaceut.9b00042
Autor:
Michael Prime, Samantha Green, Celia Dominguez, Edith Monteagudo, Malcolm Taylor, Akihiro Takano, Longbin Liu, Adrian Kotey, Wayne Thomas, Zhisheng Jia, Anthony P Dickie, Catherine Greenaway, Samuel Coe, Miklós Tóth, John Wityak, Vinod Khetarpal, Sergio Menta, Simone Esposito, Katarina Vanräs, Andreas Ebneth, John E. Mangette, Ian Wigginton, Todd Herbst, Peter Johnson, Sabine Schaertl, Vladimir Stepanov, Jonathan Bard, Sebastien Galan, Elise Gadouleau, Randall Davis, Christopher John Brown, Frank Herrmann, Richard W Marston, Darshan Gunvant Vaidya, Laura Orsatti, Xuemei Chen, Martina Nibbio, Manuela Heßmann, Joanne Sproston, Matthew R Mills, Ignacio Munoz-Sanjuan, Daniel Clark-Frew, Derek Alexander Weddell, Ladislav Mrzljak, Christoph Scheich, Xinjie Gai, Christer Halldin, Sangram Nag, Lee Matthew, Patricia Miranda-Azpiazu, Paul Giles, Thomas Krulle, Alexander Kiselyov, Marie Svedberg, Sarah Hayes
Publikováno v:
Journal of medicinal chemistry. 63(15)
Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of Huntington's disease (HD) pathology. A high-affinity ligand specific for mHTT aggregates could serv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bbb7331f2e0517d6d294883abdcc6f
https://pubmed.ncbi.nlm.nih.gov/32662649
https://pubmed.ncbi.nlm.nih.gov/32662649
Autor:
Ivan Fini, Maria Veneziano, Vinod Khetarpal, Elena Bracacel, Todd Herbst, Ignacio Munoz-Sanjuan, Mark Rose, Giulio Auciello, Edith Monteagudo, Alessandro Rosa, Celia Dominguez, Odalys Gonzalez Paz, Antonella Cellucci, Annalise Di Marco, Maria Rosaria Battista, Isabelle Gloaguen, Domenico Vignone
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 994, p 994 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 994, p 994 (2020)
The blood-brain barrier (BBB) is responsible for the homeostasis between the cerebral vasculature and the brain and it has a key role in regulating the influx and efflux of substances, in healthy and diseased states. Stem cell technology offers the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a041cf35a29cb7bd1fddf8e63e91991e
http://hdl.handle.net/11573/1387940
http://hdl.handle.net/11573/1387940
Autor:
Laura Orsatti, Roberto Speziale, Kathryn A. Lyons, Fulvia Caretti, Maria Vittoria Orsale, Edith Monteagudo, Maria G. Beconi, Fabio Bonelli, Maria Veneziano, Todd Herbst, Ignacio Munoz-Sanjuan, Celia Dominguez, Matteo Zini, Kelvin Chan, Leticia Toledo-Sherman
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 107:426-431
Neuroactive metabolites in the kynurenine pathway of tryptophan catabolism are associated with neurodegenerative disorders. Tryptophan is transported across the blood–brain barrier and converted via the kynurenine pathway to N-formyl- l -kynurenine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4572036f528eeda5c4833d5434d89f0d
https://doi.org/10.1016/j.jpba.2015.01.030
https://doi.org/10.1016/j.jpba.2015.01.030
Autor:
Todd Herbst, Stanislaw Rachwal, Sheng Zhong, Lee Steven, Peter E. Haroldsen, Rudolf Mueller, Leslie J. Street, Yong-Xin Li, Mark A. Varney, Gary A. Rogers, Steven W. Johnson, Susan Tanimura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6170-6175
AMPA receptors (AMPARs) have been demonstrated to be an important therapeutic CNS target. A series of substituted benzotriazinone and benzopyrimidinone derivatives were prepared with the aim to improve in vivo activity over the previously reported bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3663a98e7b3e34a0dc3c1a46155fd80e
https://doi.org/10.1016/j.bmcl.2011.07.098
https://doi.org/10.1016/j.bmcl.2011.07.098