Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Todd Heallen"'
Autor:
Jianxin Wang, Min Li, Li Tang, Bao Nguyen, Jun Wang, James F. Martin, Xiaolei Zhao, Todd Heallen, Shijie Liu
Publikováno v:
Circ Res
Rationale: During neonatal heart regeneration, the fibrotic response, which is required to prevent cardiac rupture, resolves via poorly understood mechanisms. Deletion of the Hippo pathway gene Sav in adult cardiomyocytes increases Yap activity and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19feb0c9577cf82229e10101650c39fb
https://doi.org/10.1161/circresaha.121.318966
https://doi.org/10.1161/circresaha.121.318966
Autor:
Ke Li, Leonardo Wagner Florencio, Emerson C. Perin, Francisco Grisanti, James T. Willerson, Li Tang, Yidan Wang, John Leach, Sui Zhang, Todd Heallen, James F. Martin, Shijie Liu
Publikováno v:
Sci Transl Med
Human heart failure, a leading cause of death worldwide, is a prominent example of a chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an inhibitory kinase cascade that represses adult heart muscle cell (cardiomyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f631938d37b963d1f7e10541916324
https://europepmc.org/articles/PMC9476348/
https://europepmc.org/articles/PMC9476348/
Autor:
Todd Heallen, Ke Li, Sui Zhang, Leonardo Wagner, Yidan Wang, James T. Willerson, Shijie Liu, Emerson C. Perin, James F. Martin, Li Tang
Publikováno v:
Circulation Research. 127
Heart failure (HF), a devastating disease and a leading cause of death worldwide, is an unmet clinical need. The Hippo pathway, an inhibitory kinase cascade, represses adult cardiomyocyte (CM) proliferation post-myocardial infarction (MI) in rodent m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f7ef1c21dfbedcdf2e62d22fcac669a
https://doi.org/10.1161/res.127.suppl_1.293
https://doi.org/10.1161/res.127.suppl_1.293
Publikováno v:
Cold Spring Harb Perspect Biol
Within the realm of zoological study, the question of how an organism reaches a specific size has been largely unexplored. Recently, studies performed to understand the regulation of organ size have revealed that both cellular signals and external cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4924bd648f3ad2891f1a0c913e917809
https://europepmc.org/articles/PMC7050588/
https://europepmc.org/articles/PMC7050588/
Autor:
Min Zhang, Todd Heallen, Mahdis Rahmani, James T. Willerson, Matthew C. Hill, Yuka Morikawa, John Leach, James F. Martin, Ana Maria Segura
Publikováno v:
Nature. 550:260-264
Deletion of the Hippo pathway component Salvador in mouse hearts with established ischaemic heart failure after myocardial infarction induces a reparative genetic program with increased scar border vascularity, reduced fibrosis, and recovery of pumpi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe67c66140fd40fc5c3524f9c93a1c1
https://doi.org/10.1038/nature24045
https://doi.org/10.1038/nature24045
Publikováno v:
Nature
The regenerative capacity of the adult mammalian heart is limited, because of the reduced ability of cardiomyocytes to progress through mitosis. Endogenous cardiomyocytes have regenerative capacity at birth but this capacity is lost postnatally, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8f39d767561a06e6cf6b1fe034a70b
https://doi.org/10.1038/nature22979
https://doi.org/10.1038/nature22979
Publikováno v:
Circ Res
After myocardial injury, cardiomyocyte loss cannot be corrected by using currently available clinical treatments. In recent years, considerable effort has been made to develop cell-based cardiac repair therapies aimed at correcting for this loss. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6165ee0cd7e05bd27484a1a6bcae3e10
https://pubmed.ncbi.nlm.nih.gov/31120819
https://pubmed.ncbi.nlm.nih.gov/31120819
Autor:
James F. Martin, Todd Heallen
Publikováno v:
Nature biomedical engineering. 2(5)
The sustained delivery of extracellular vesicles, secreted by induced-pluripotent-stem-cell-derived cardiomyocytes, through a hydrogel patch promotes cardiac recovery after myocardial infarction in rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab25dbb37a9fb4a948196c3974a181c
https://pubmed.ncbi.nlm.nih.gov/30936454
https://pubmed.ncbi.nlm.nih.gov/30936454
Publikováno v:
Nature reviews. Cardiology. 15(11)
The Hippo-YAP (Yes-associated protein) pathway is an evolutionarily and functionally conserved regulator of organ size and growth with crucial roles in cell proliferation, apoptosis, and differentiation. This pathway has great potential for therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742919c6c3b71bfbdc306f5a862cbb76
https://pubmed.ncbi.nlm.nih.gov/30111784
https://pubmed.ncbi.nlm.nih.gov/30111784
Publikováno v:
Circulation Research. 121
Regeneration of mammalian heart is limited due to the extremely low renewal rate of cardiomyocytes and their inability to reenter the cell cycle. The Hippo pathway controls heart size during development and represses postnatal heart regeneration by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef2f547b61015951e38b5e8d9afff05
https://doi.org/10.1161/res.121.suppl_1.78
https://doi.org/10.1161/res.121.suppl_1.78