Výsledky vyhledávání - "Todd E. Haim"

Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents

Autor: Colin G. Nichols, Michael A. Tones, Todd E. Haim, Thomas P. Flagg, Anthony Bahinski, Randal E. Numann, Jeanne M. Nerbonne, Wei Wang

Publikováno v: Journal of Molecular and Cellular Cardiology. 48:395-405

There is considerable evidence to support a role for lipotoxicity in the development of diabetic cardiomyopathy, although the molecular links between enhanced saturated fatty acid uptake/metabolism and impaired cardiac function are poorly understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0694598a4f1fab8f366b110ebf43b0e
https://doi.org/10.1016/j.yjmcc.2009.10.004

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Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics

Autor: Candice Dowell, Jil C. Tardiff, Todd E. Haim, Theodhor Diamanti, James Scheuer

Publikováno v: Journal of Molecular and Cellular Cardiology. 42:1098-1110

Mutations in cardiac troponin T (cTnT) are linked to a severe form of Familial Hypertrophic Cardiomyopathy. Patients carrying mutations flanking the tropomyosin-binding domain of cTnT (R92L and Delta160E) develop distinct clinical syndromes. In order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de469a2718ea21d092dd6478721d489f
https://doi.org/10.1016/j.yjmcc.2007.03.906

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Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice

Autor: Sara Núñez, Steven D. Schwartz, Jil C. Tardiff, Stephen M. Factor, Todd E. Haim, Candice Dowell, Huamei He, Briar R. Ertz-Berger, Joanne S. Ingwall

Publikováno v: Proceedings of the National Academy of Sciences. 102:18219-18224

Cardiac troponin T (cTnT) is a central component of the regulatory thin filament. Mutations in cTnT have been linked to severe forms of familial hypertrophic cardiomyopathy. A mutational “hotspot” that leads to distinct clinical phenotypes has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9151e69bf5171620c398dac9d825ed02
https://doi.org/10.1073/pnas.0509181102

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Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models

Autor: Candice Dowell-Martino, Nathaniel Sibinga, Pia J. Guinto, Jil C. Tardiff, Todd E. Haim

Publikováno v: American journal of physiology. Heart and circulatory physiology. 297(2)

Naturally occurring mutations in cardiac troponin T (cTnT) result in a clinical subset of familial hypertrophic cardiomyopathy. To determine the mechanistic links between thin-filament mutations and cardiovascular phenotypes, we have generated and ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7537ecba971fd2c2b12928e15816cc
https://pubmed.ncbi.nlm.nih.gov/19502551

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Ca2+-Independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy

Autor: Colin G. Nichols, Michael A. Tones, Todd E. Haim, Attila Kovacs, Olivier Cazorla, Anthony Bahinski, Thomas P. Flagg, Maria S. Remedi, Jean E. Schaffer, Jeanne M. Nerbonne, Randal E. Numann

Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2008, 104 (1), pp.95-103. ⟨10.1161/CIRCRESAHA.108.186809⟩

International audience; Previous studies demonstrated increased fatty acid uptake and metabolism in MHC-FATP transgenic mice that overexpress fatty acid transport protein (FATP)1 in the heart under the control of the ␣-myosin heavy chain (␣-MHC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731d014638e837aa1a6be9c471d6d87b
https://hal.umontpellier.fr/hal-01824362

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