Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Todd E Golde"'
Autor:
Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp n/a-n/a (2022)
Abstract Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous syst
Externí odkaz:
https://doaj.org/article/10d3c6ff5fb2440ca2d3a9bf9989e4aa
Autor:
Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 950-966 (2017)
Abstract γ‐Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers is therapeutic. Using novel assays to probe effects of GSIs against a broader pa
Externí odkaz:
https://doaj.org/article/3fbd1320bd9d4856944b5a4a455c213b
Autor:
Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp n/a-n/a (2018)
Abstract Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD‐associa
Externí odkaz:
https://doaj.org/article/7dfbdafcfc1640e899512df47529113f
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204367 (2018)
Phosphorylation of the microtubule associated protein tau is an important modulator of its normal physiological functioning; however, it may also contribute to tau mis-folding and aggregation in neurodegenerative diseases, which are collectively term
Externí odkaz:
https://doaj.org/article/1e294b5fe02c4eafa57634b75e6b67ad
Autor:
Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasson
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195211 (2018)
Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau. The
Externí odkaz:
https://doaj.org/article/33df30cd1ad04095b1e8ac375eb2c2ad
Autor:
Swati Khare, Jerelyn A Nick, Yalan Zhang, Kira Galeano, Brittany Butler, Habibeh Khoshbouei, Sruti Rayaprolu, Tyisha Hathorn, Laura P W Ranum, Lisa Smithson, Todd E Golde, Martin Paucar, Richard Morse, Michael Raff, Julie Simon, Magnus Nordenskjöld, Karin Wirdefeldt, Diego E Rincon-Limas, Jada Lewis, Leonard K Kaczmarek, Pedro Fernandez-Funez, Harry S Nick, Michael F Waters
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0173565 (2017)
The autosomal dominant spinocerebellar ataxias (SCAs) are a diverse group of neurological disorders anchored by the phenotypes of motor incoordination and cerebellar atrophy. Disease heterogeneity is appreciated through varying comorbidities: dysarth
Externí odkaz:
https://doaj.org/article/97e9d48d1cdd49d1b21e559becfb6f09
Autor:
Jess-Karan S Dhillon, Cara Riffe, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Todd E Golde, Benoit I Giasson
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184731 (2017)
Synucleinopathies are a spectrum of neurodegenerative diseases characterized by the intracellular deposition of the protein α-synuclein leading to multiple outcomes, including dementia and Parkinsonism. Recent findings support the notion that across
Externí odkaz:
https://doaj.org/article/bfe68da14bd048068f6cc63c309e977b
Autor:
Awilda M Rosario, Pedro E Cruz, Carolina Ceballos-Diaz, Michael R Strickland, Zoe Siemienski, Meghan Pardo, Keri-Lyn Schob, Andrew Li, George V Aslanidi, Arun Srivastava, Todd E Golde, Paramita Chakrabarty
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, a
Externí odkaz:
https://doaj.org/article/97a40b710dcb4b2eb9bbcd9f5345793e
Autor:
Yong Ran, Gabriela Z Ladd, Carolina Ceballos-Diaz, Joo In Jung, Doron Greenbaum, Kevin M Felsenstein, Todd E Golde
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128619 (2015)
The signal peptide peptidases (SPPs) are biomedically important proteases implicated as therapeutic targets for hepatitis C (human SPP, (hSPP)), plasmodium (Plasmodium SPP (pSPP)), and B-cell immunomodulation and neoplasia (signal peptide peptidase l
Externí odkaz:
https://doaj.org/article/48308500d3144c888dde4d5d656980db
Autor:
Christian B Lessard, Barbara A Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E Golde, Edward H Koo
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144758 (2015)
The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD) linked APP and PSEN mutations can be related to changes in both ε-cleavage site utilization and subsequent step-wise cleavage. Cleavage at the ε-site releases the amyloid
Externí odkaz:
https://doaj.org/article/cb28119b986b404a9c1fddfeba2d7131