Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Todd Duncan"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The ratio of saturated to monounsaturated fatty acids, thought to play a critical role in many cellular functions, is regulated by stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Prev
Externí odkaz:
https://doaj.org/article/4f14d21c9ad54fb0a314a6e4bab619f9
Autor:
Saumil Sethna, Patrick A. Scott, Arnaud P. J. Giese, Todd Duncan, Xiaoying Jian, Sheikh Riazuddin, Paul A. Randazzo, T. Michael Redmond, Steven L. Bernstein, Saima Riazuddin, Zubair M. Ahmed
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and subse
Externí odkaz:
https://doaj.org/article/28f9c426a95d413a8bcf70e1675378bc
Autor:
Saumil Sethna, Wadih M Zein, Sehar Riaz, Arnaud PJ Giese, Julie M Schultz, Todd Duncan, Robert B Hufnagel, Carmen C Brewer, Andrew J Griffith, T Michael Redmond, Saima Riazuddin, Thomas B Friedman, Zubair M Ahmed
Publikováno v:
eLife, Vol 10 (2021)
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of PCDH15 (USH1F) has an ~2% carrier frequency amongst Ashkenazi Jews accounts for
Externí odkaz:
https://doaj.org/article/b6069badb6b14498bff5ec71588e5683
Autor:
Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B Gutierrez, Nathan L Mata, T Michael Redmond
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176487 (2017)
The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity, diabetes, and ocular disease. Yet, the mechanisms of action for its pleiotropic effects are still
Externí odkaz:
https://doaj.org/article/814b6ba31e1e4c1cbfa7997dd61c4ec9
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 7, Pp 1222-1228 (1999)
We previously have cloned and characterized a retinoid- and fatty acid-binding glycoprotein (RFABG) isolated from the heads of Drosophila melanogaster. The protein is composed of two glycosylated subunits (Mr = >200,000 and 70,000) and is a member of
Externí odkaz:
https://doaj.org/article/0d65a1024f364548aa33155c47041674
The ratio of saturated to monounsaturated fatty acids, thought to play a critical role in many cellular functions, is regulated by stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Previously, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709359690503a15c2b437599aa8fc45e
https://doi.org/10.21203/rs.3.rs-1972330/v1
https://doi.org/10.21203/rs.3.rs-1972330/v1
Autor:
Julie M. Schultz, Zubair M. Ahmed, Robert B. Hufnagel, Todd Duncan, Sehar Riaz, Carmen C. Brewer, Thomas B. Friedman, Andrew J. Griffith, Saumil Sethna, Arnaud P. J. Giese, T. Michael Redmond, Wadih M. Zein, Saima Riazuddin
Publikováno v:
eLife, Vol 10 (2021)
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of PCDH15 (USH1F) has an ~2% carrier frequency amongst Ashkenazi Jews accounts for
Autor:
Arnaud P. J. Giese, Saumil Sethna, Julie M. Schultz, Sehar Riaz, Andrew J. Griffith, T. Michael Redmond, Wadih M. Zein, Thomas B. Friedman, Carmen C. Brewer, Saima Riazuddin, Zubair Ahmed, Robert B. Hufnagel, Todd Duncan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f6c18299b0970e362d21d1291c42a3c
https://doi.org/10.7554/elife.67361.sa2
https://doi.org/10.7554/elife.67361.sa2
Autor:
Saima Riazuddin, Zubair M. Ahmed, Robert B. Hufnagel, Todd Duncan, Sehar Riaz, T M Redmond, Arnaud P. J. Giese, Andrew J. Griffith, Carmen C. Brewer, Saumil Sethna, Thomas B. Friedman, Wadih M. Zein, Julie M. Schultz
Usher syndrome type I (USH1) is characterized by congenital deafness, vestibular areflexia, and progressive retinal degeneration with age. The protein-truncating p.Arg245* founder variant of PCDH15 has an ~2% carrier frequency among Ashkenazi Jews, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cad16a601dca337a4948cf4e28cba329
https://doi.org/10.1101/2021.06.08.447565
https://doi.org/10.1101/2021.06.08.447565
Autor:
Joshua Lerner, Jianguo Fan, Arjun Ponduri, Katherine Peterson, Lijin Dong, Graeme Wistow, Vatsala Sagar, Shabnam Parsa, Todd Duncan, Dinusha Rajapakse
Publikováno v:
Exp Eye Res
Vision requires the transport and recycling of the pigment 11-cis retinaldehyde (retinal) between the retinal pigment epithelium (RPE) and photoreceptors. 11-cis retinal is also required for light-mediated photoreceptor death in dark-adapted mouse ey