Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

Autor: Milene R. Malheiros-Lima, Virginia E. Hawkins, Todd Dubreuil, Thiago S. Moreira, Daniel K Mulkey, Ian C. Wenker, Ana C. Takakura, Elliot M Rodriguez, Colin M Cleary, Mark T. Nelson, Ashley Trinh

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
eLife, Vol 6 (2017)
eLife
Hawkins, V E, Takakura, A C, Trinh, A, Malheiros-Lima, M R, Cleary, C M, Wenker, I C, Dubreuil, T, Rodriguez, E M, Nelson, M T, Moreira, T S & Mulkey, D K 2017, ' Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe ', eLife, vol. 6, e25232 . https://doi.org/10.7554/eLife.25232, https://doi.org/10.7554/eLife.25232

Cerebral blood flow is highly sensitive to changes in CO2/H+ where an increase in CO2/H+ causes vasodilation and increased blood flow. Tissue CO2/H+ also functions as the main stimulus for breathing by activating chemosensitive neurons that control r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15adebbcb5e13d61a8966166b97988e
https://doi.org/10.7554/elife.25232

Conditional knockdown of Kir4.1 in astrocytes blunts the hypercapnic respiratory response in awake mice (872.7)

Autor: Daniel K. Mulkey, Laura Bellemare, Fu-Shan Kuo, Virginia E. Hawkins, Todd Dubreuil, Diana Perez

Publikováno v: The FASEB Journal. 28

Central chemoreception is the mechanisms by which the brain regulates breathing in response to changes in tissue CO2/H+. The retrotrapezoid nucleus (RTN) has been identified as a key locus for central respiratory control. Neurons in this region sense

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d53cf960d4cf6c58a50ce12cfc9d3fb5
https://doi.org/10.1096/fasebj.28.1_supplement.872.7