Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Todd D. Swarthout"'
Autor:
Uri Obolski, Todd D. Swarthout, Akuzike Kalizang’oma, Thandie S. Mwalukomo, Jia Mun Chan, Caroline M. Weight, Comfort Brown, Rory Cave, Jen Cornick, Arox Wadson Kamng’ona, Jacquline Msefula, Giuseppe Ercoli, Jeremy S. Brown, José Lourenço, Martin C. Maiden, Neil French, Sunetra Gupta, Robert S. Heyderman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Streptococcus pneumoniae causes substantial mortality among children under 5-years-old worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing vaccine serotype disease, but emergence of non-vaccine serotypes and
Externí odkaz:
https://doaj.org/article/91b8c2d41692430f887ad9109b2efaa9
Autor:
Deus Thindwa, Samuel Clifford, Jackie Kleynhans, Anne von Gottberg, Sibongile Walaza, Susan Meiring, Todd D. Swarthout, Elizabeth Miller, Peter McIntyre, Nick Andrews, Zahin Amin-Chowdhury, Norman Fry, Kondwani C. Jambo, Neil French, Samanta Cristine Grassi Almeida, Shamez N. Ladhani, Robert S. Heyderman, Cheryl Cohen, Maria Cristina de Cunto Brandileone, Stefan Flasche
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Vaccination against invasive pneumococcal disease is recommended for older adults but the optimal age group to target has not been determined and may vary by epidemiological setting. Here, the authors use statistical modelling to estimate the optimal
Externí odkaz:
https://doaj.org/article/46ec24eaffaa42cb9c48d6db1517712f
Autor:
Amir Kirolos, Todd D. Swarthout, Andrew A. Mataya, Farouck Bonomali, Comfort Brown, Jacquline Msefula, Naor Bar-Zeev, Pui-Ying Iroh Tam, Maaike Alaerts, Sithembile Bilima, Robert S. Heyderman, Neil French
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Introduction The introduction of PCV13 to the Malawi infant immunization schedule in 2011 has been associated with reduced disease from Streptococcus pneumoniae. Improved understanding of serotypes with high invasive potential can guide futu
Externí odkaz:
https://doaj.org/article/63167f6b39844ccaba2eed1a4eeaad19
Autor:
Upendo L. Mseka, Jonathan Mandolo, Kenneth Nyoni, Oscar Divala, Dzinkambani Kambalame, Daniel Mapemba, Moses Kamzati, Innocent Chibwe, Marc Y.R. Henrion, Kingsley Manda, Deus Thindwa, Memory Mvula, Bright Odala, Raphael Kamng'ona, Nelson Dzinza, Khuzwayo C. Jere, Nicholas Feasey, Antonia Ho, Abena S. Amoah, Melita Gordon, Todd D. Swarthout, Amelia Crampin, Robert S. Heyderman, Matthew Kagoli, Evelyn Chitsa-Banda, Collins Mitambo, John Phuka, Benson Chilima, Watipaso Kasambara, Kondwani C. Jambo, Annie Chauma-Mwale
Publikováno v:
EClinicalMedicine, Vol 56, Iss , Pp 101800- (2023)
Summary: Background: The B.1.1.529 (Omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the fourth COVID-19 pandemic wave across the southern African region, including Malawi. The seroprevalence of SARS-Co
Externí odkaz:
https://doaj.org/article/d886e6a896034979824c21646a6c6ea9
Autor:
Marah G. Chibwana, Herbert W. Thole, Cat Anscombe, Philip M. Ashton, Edward Green, Kayla G. Barnes, Jen Cornick, Ann Turner, Desiree Witte, Sharon Nthala, Chikondi Thom, Felistas Kanyandula, Anna Ainani, Natasha Mtike, Hope Tambala, Veronica N’goma, Dorah Mwafulirwa, Erick Asima, Ben Morton, Markus Gmeiner, Zaziwe Gundah, Gift Kawalazira, Neil French, Nicholas Feasey, Robert S. Heyderman, Todd D. Swarthout, Kondwani C. Jambo
Publikováno v:
PLOS Global Public Health, Vol 3, Iss 3 (2023)
The SARS-CoV-2 Omicron variant has resulted in a high number of cases, but a relatively low incidence of severe disease and deaths, compared to the pre-Omicron variants. Therefore, we assessed the differences in symptom prevalence between Omicron and
Externí odkaz:
https://doaj.org/article/366afb93d3ba4e7091f3ab0fe452397c
Autor:
Todd D. Swarthout, Claudio Fronterre, José Lourenço, Uri Obolski, Andrea Gori, Naor Bar-Zeev, Dean Everett, Arox W. Kamng’ona, Thandie S. Mwalukomo, Andrew A. Mataya, Charles Mwansambo, Marjory Banda, Sunetra Gupta, Peter Diggle, Neil French, Robert S. Heyderman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Impact of pneumococcal conjugate vaccines (PCV) in controlling carriage needs to be evaluated to inform vaccine policy. Here, Swarthout et al. show in a prospective rolling cross-sectional study in Malawi a high residual prevalence of vaccine-serotyp
Externí odkaz:
https://doaj.org/article/ae7ea6f71d874cce94b21be785b45e8c
Autor:
Andrea Gori, Odile B. Harrison, Ethwako Mlia, Yo Nishihara, Jia Mun Chan, Jacquline Msefula, Macpherson Mallewa, Queen Dube, Todd D. Swarthout, Angela H. Nobbs, Martin C. J. Maiden, Neil French, Robert S. Heyderman
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Streptococcus agalactiae (group B streptococcus; GBS) is a colonizer of the gastrointestinal and urogenital tracts, and an opportunistic pathogen of infants and adults. The worldwide population of GBS is characterized by clonal complexes (CC
Externí odkaz:
https://doaj.org/article/993fbc4e328d4f2eadcd44b11a7cd9b1
Autor:
Maria Deloria Knoll, Julia C. Bennett, Maria Garcia Quesada, Eunice W. Kagucia, Meagan E. Peterson, Daniel R. Feikin, Adam L. Cohen, Marissa K. Hetrich, Yangyupei Yang, Jenna N. Sinkevitch, Krow Ampofo, Laurie Aukes, Sabrina Bacci, Godfrey Bigogo, Maria-Cristina C. Brandileone, Michael G. Bruce, Romina Camilli, Jesús Castilla, Guanhao Chan, Grettel Chanto Chacón, Pilar Ciruela, Heather Cook, Mary Corcoran, Ron Dagan, Kostas Danis, Sara de Miguel, Philippe De Wals, Stefanie Desmet, Yvonne Galloway, Theano Georgakopoulou, Laura L. Hammitt, Markus Hilty, Pak-Leung Ho, Sanjay Jayasinghe, James D. Kellner, Jackie Kleynhans, Mirjam J. Knol, Jana Kozakova, Karl Gústaf Kristinsson, Shamez N. Ladhani, Claudia S. Lara, Maria Eugenia León, Tiia Lepp, Grant A. Mackenzie, Lucia Mad’arová, Allison McGeer, Tuya Mungun, Jason M. Mwenda, J. Pekka Nuorti, Néhémie Nzoyikorera, Kazunori Oishi, Lucia Helena De Oliveira, Metka Paragi, Tamara Pilishvili, Rodrigo Puentes, Eric Rafai, Samir K. Saha, Larisa Savrasova, Camelia Savulescu, J. Anthony Scott, Kevin J. Scott, Fatima Serhan, Lena Petrova Setchanova, Nadja Sinkovec Zorko, Anna Skoczyńska, Todd D. Swarthout, Palle Valentiner-Branth, Mark van der Linden, Didrik F. Vestrheim, Anne von Gottberg, Inci Yildirim, Kyla Hayford, the PSERENADE Team
Publikováno v:
Microorganisms, Vol 9, Iss 4, p 742 (2021)
Serotype-specific surveillance for invasive pneumococcal disease (IPD) is essential for assessing the impact of 10- and 13-valent pneumococcal conjugate vaccines (PCV10/13). The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE
Externí odkaz:
https://doaj.org/article/3f50a3eee994443ab38c7fe4c3a482ca
Autor:
Asia-Sophia Wolf, Elena Mitsi, Scott Jones, Simon P. Jochems, Lucy Roalfe, Deus Thindwa, James E. Meiring, Jacquline Msefula, Farouck Bonomali, Tikhala Makhaza Jere, Maurice Mbewe, Andrea M. Collins, Stephen B. Gordon, Melita A. Gordon, Daniela M. Ferreira, Neil French, David Goldblatt, Robert S. Heyderman, Todd D. Swarthout
Publikováno v:
Vaccine. 40:7201-7210
Childhood pneumococcal conjugate vaccine (PCV) protects against invasive pneumococcal disease caused by vaccine-serotype (VT) Streptococcus pneumoniae by generating opsonophagocytic anti-capsular antibodies, but how vaccination protects against and r
Autor:
Jacquline Msefula, Gaurav Kwatra, Kondwani C Jambo, Andrew Likaka, Adamson S Muula, Zanele Makhado, Brewster Moyo, Penny L. Moore, Jonathan Mandolo, Aubrey Samon, Nonkululeko Mzindle, Thom Mfune, Thandeka Moyo-Gwete, Comfort Brown, Marc Henrion, Newton Kalata, Todd D. Swarthout, Frances Ayres, Bridon M'baya, Robert S. Heyderman, Neil French, Natasha Nsamala, Thopisang Motlou
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
BMC Medicine
BMC Medicine
Background By August 2021, the COVID-19 pandemic has been less severe in sub-Saharan Africa than elsewhere. In Malawi, there have been three subsequent epidemic waves. We therefore aimed to describe the dynamics of SARS-CoV-2 exposure in Malawi. Meth