Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Todd D. Merchen"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Renal tubular epithelial cells (TECs) are the primary targets of ischemia–reperfusion injury (IRI) and rejection by the recipient’s immune response in kidney transplantation (KTx). However, the molecular mechanism of rejection and IRI remains to
Externí odkaz:
https://doaj.org/article/7fdf70b954bf43a99fbec21510124f04
Autor:
Youli Wang, N. Stanley Nahman, Thomas Z. Thompson, Philip B. Cox, Xuexiu Fang, Sam Ho, Andrew Harner, Todd D. Merchen, Daniel T. Kleven
Publikováno v:
Transplantation Proceedings. 51:2124-2131
Background Acute rejection of a kidney allograft results from adaptive immune responses and marked inflammation. The eicosanoid prostaglandin E2 (PGE2) modulates the inflammatory response, is generated by cyclooxygenase 2 (COX-2), and binds to 1 of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2398514aedc39eb2373f4a5aaaef707b
https://doi.org/10.1016/j.transproceed.2019.05.016
https://doi.org/10.1016/j.transproceed.2019.05.016
Identification of α‐fetoprotein‐specific T‐cell receptors for hepatocellular carcinoma immunotherapy
Autor:
Juan Wu, Yukai He, Xiaotao Jiang, Todd D. Merchen, Wei Zhu, Lan Wang, Yibing Peng, Yuan Hong, Edward J. Kruse, Lei Huang, Heping Liu, Esteban Celis, Qi Li
Publikováno v:
Hepatology
Hepatocellular carcinoma (HCC) is the major form of liver cancer for which there is no effective therapy. Genetic modification with T-cell receptors (TCRs) specific for HCC-associated antigens, such as α-fetoprotein (AFP), can potentially redirect h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a19fa595f51bda9bb313f8afc5ad4cf
https://doi.org/10.1002/hep.29844
https://doi.org/10.1002/hep.29844
Autor:
Yibing Peng, Junping Xie, Yuan Hong, Edward J. Kruse, Lei Huang, Todd D. Merchen, Ning Fu, Yukai He, Zong Sheng Guo, Sha Wu, Dayong Dong, David L. Bartlett, Lan Wang, Wei Zhu
Publikováno v:
Cancer Immunology Research. 5:908-919
To understand why vaccine-activated tumor-specific T cells often fail to generate antitumor effects, we studied two α-fetoprotein–specific CD8+ T cells (Tet499 and Tet212) that had different antitumor effects. We found that Tet499 required high an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e3d0f6bfa3bb8cfded61a531c44546
https://doi.org/10.1158/2326-6066.cir-17-0016
https://doi.org/10.1158/2326-6066.cir-17-0016
Autor:
Youli Wang, Chak-Sum Ho, Todd D. Merchen, Eslam Mohamed, Jennifer L. Waller, Xuexiu Fang, Randi L. Lassiter, N. Stanley Nahman, Ryan P. Jajosky, Daniel T. Kleven, Miao Yu, Thomas Z. Thompson
Publikováno v:
Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 66(8)
In kidney transplantation acute allograft rejection is the most common cause of late allograft loss. Changes in indoleamine 2,3 dioxygenase (IDO) activity, which catabolizes the degradation of tryptophan to kynurenine, may predict rejection. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a562ebf3c8aca444b1634f5e5ec7e8b
https://pubmed.ncbi.nlm.nih.gov/30006478
https://pubmed.ncbi.nlm.nih.gov/30006478
Publikováno v:
The American surgeon. 83(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48f85486c9854e39daa5713cb8742eda
https://pubmed.ncbi.nlm.nih.gov/29336742
https://pubmed.ncbi.nlm.nih.gov/29336742
Autor:
Youli Wang, Chak-Sum Ho, Sandra W. Helman, Xuexiu Fang, Arina Ghaffari, Ryan P. Jajosky, Todd D. Merchen, Randi L. Lassiter, Matt Winn, N. Stanley Nahman, Daniel T. Kleven
Publikováno v:
Transplant immunology. 42
Pigs represent a desirable animal model for the study of rejection in kidney transplantation with inbred Yucatan miniature swine (YMS) the most commonly studied strain due to well defined swine leukocyte antigen (SLA) genotypes. However, limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5095bb2db11727a6db5a3e7e9fd42d75
https://pubmed.ncbi.nlm.nih.gov/28495618
https://pubmed.ncbi.nlm.nih.gov/28495618
Publikováno v:
The American Surgeon. 83:480-481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::456cd30b40f9d73fa19f477ad0dc54f6
https://doi.org/10.1177/000313481708301206
https://doi.org/10.1177/000313481708301206
Autor:
Yasuhiro Nakamura, William E. Rainey, Hironobu Sasano, Todd D. Merchen, Juilee Rege, Tao Wang
The human adrenal zona fasciculata (ZF) and zona reticularis (ZR) are responsible for the production of cortisol and 19-carbon steroids (often called adrenal androgens), respectively. However, the gene profiles and exact molecular mechanisms leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f534da8d2b37cdba49a97d318e30ae
https://europepmc.org/articles/PMC3942232/
https://europepmc.org/articles/PMC3942232/
Autor:
David M. Pollock, Rachel Harbarger, Todd D. Merchen, Eiko Kitamura, N. Stanley Nahman, Andrew L. Mellor, Arina Ghaffari, Erika I. Boesen, Robert H. Podolsky, John R. Gardner
Publikováno v:
Transplant immunology. 30(4)
Background Indoleamine 2,3 dioxygenase (IDO) degrades the essential amino acid tryptophan and has been shown to minimize rejection in animal models of renal transplantation. Ischemia-reperfusion injury (IRI) is unavoidable in renal transplantation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290c58962cf9ff695df7d959cb081a73
https://pubmed.ncbi.nlm.nih.gov/24751756
https://pubmed.ncbi.nlm.nih.gov/24751756