Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Todd D. Gould"'
Autor:
Ruin Moaddel, Cristan A. Farmer, Mani Yavi, Bashkim Kadriu, Min Zhu, Jinshui Fan, Qinghua Chen, Elin Lehrmann, Giovanna Fantoni, Supriyo De, Caio H. Mazucanti, Elia E. Acevedo-Diaz, Peixiong Yuan, Todd D. Gould, Lawrence T. Park, Josephine M. Egan, Luigi Ferrucci, Carlos A. Zarate, Jr.
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108527- (2023)
Summary: Ketamine is a treatment for both refractory depression and chronic pain syndromes. In order to explore ketamine’s potential mechanism of action and whether ketamine or its metabolites cross the blood brain barrier, we examined the pharmaco
Externí odkaz:
https://doaj.org/article/dd7ad1b3a925423d97ebe742d4f5433a
Autor:
Ruin Moaddel, Panos Zanos, Cristan A. Farmer, Bashkim Kadriu, Patrick J. Morris, Jacqueline Lovett, Elia E. Acevedo-Diaz, Grace W. Cavanaugh, Peixiong Yuan, Mani Yavi, Craig J. Thomas, Lawrence T. Park, Luigi Ferrucci, Todd D. Gould, Carlos A. Zarate
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Subanesthetic-dose racemic (R,S)-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD) and bipolar disorder (BD) and has also been shown to effectively treat neuropathic pain, com
Externí odkaz:
https://doaj.org/article/a822b41b1e6245a389bcef25692869af
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A single subanesthetic infusion of ketamine can rapidly alleviate symptoms of treatment-resistant major depression. Since repeated administration is required to sustain symptom remission, it is important to characterize the potential untowar
Externí odkaz:
https://doaj.org/article/3c665b6efe044095b2dd0e68c18d5190
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Fluctuating hormone levels, such as estradiol might underlie the difference in the prevalence of psychiatric disorders observed in women vs. men. Estradiol exert its effects primarily through binding on the two classical estrogen receptor subtypes, a
Externí odkaz:
https://doaj.org/article/9bc7e1f5e51847939a2a908ef4b2d045
Autor:
Brandi Quintanilla, Gustavo C. Medeiros, Dede Greenstein, Peixiong Yuan, Jenessa N. Johnston, Lawrence T. Park, Fernando S. Goes, Todd D. Gould, Carlos A. Zarate
Publikováno v:
Journal of Clinical Psychopharmacology. 43:89-96
Autor:
Polymnia Georgiou, Panos Zanos, Ta-Chung M. Mou, Xiaoxian An, Danielle M. Gerhard, Dilyan I. Dryanovski, Liam E. Potter, Jaclyn N. Highland, Carleigh E. Jenne, Brent W. Stewart, Katherine J. Pultorak, Peixiong Yuan, Chris F. Powels, Jacqueline Lovett, Edna F. R. Pereira, Sarah M. Clark, Leonardo H. Tonelli, Ruin Moaddel, Carlos A. Zarate, Ronald S. Duman, Scott M. Thompson, Todd D. Gould
Publikováno v:
Nat Neurosci
We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its bioactive metabolite (2R,6R)-hydroxynorketamine. Mice showed aversion to the scent of male
Autor:
Naushaba Hasin, Lace M. Riggs, Tatyana Shekhtman, Justin Ashworth, Robert Lease, Rediet T. Oshone, Elizabeth M. Humphries, Judith A. Badner, Pippa A. Thomson, David C. Glahn, David W. Craig, Howard J. Edenberg, Elliot S. Gershon, Francis J. McMahon, John I. Nurnberger, Peter P. Zandi, John R. Kelsoe, Jared C. Roach, Todd D. Gould, Seth A. Ament
Publikováno v:
Hasin, N, Riggs, L M, Shekhtman, T, Ashworth, J, Lease, R, Oshone, R T, Humphries, E M, Badner, J A, Thomson, P A, Glahn, D C, Craig, D W, Edenberg, H J, Gershon, E S, McMahon, F J, Nurnberger, J I, Zandi, P P, Kelsoe, J R, Roach, J C, Gould, T D & Ament, S A 2022, ' Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder ', Molecular Psychiatry . https://doi.org/10.1038/s41380-022-01609-4
Bipolar disorder is an often-severe mental health condition characterized by alternation between extreme mood states of mania and depression. Despite strong heritability and the recent identification of 64 common variant risk loci of small effect, pa
Autor:
Jaclyn N Highland, Cristan A Farmer, Panos Zanos, Jacqueline Lovett, Carlos A Zarate, Ruin Moaddel, Todd D Gould
Publikováno v:
J Psychopharmacol
Background: Ketamine is rapidly metabolized to norketamine and hydroxynorketamine (HNK) metabolites. In female mice, when compared to males, higher levels of ( 2R,6R;2S,6S)-HNK have been observed following ketamine treatment, and higher levels of ( 2
Autor:
Evan M. Hess, Todd D. Gould
Publikováno v:
Science. 379:642-643
Psychedelics act on intracellular serotonin receptors that are not accessible by serotonin alone
Autor:
Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate, Scott M. Thompson, Todd D. Gould
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience.
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the relevance of this pharmacology to its rapid (within hours of administration) antidepressant actions, which depend on mechanisms convergent with strengthening of excitator