Rapid characterization of the fatty acyl composition of complex lipids by collision-induced dissociation time-of-flight mass spectrometry

Autor: Steven Wynn Esch, Pamela Tamura, Alexis A. Sparks, Mary R. Roth, Shivakumar P. Devaiah, Ernst Heinz, Xuemin Wang, Todd D. Williams, Ruth Welti

Publikováno v: Journal of Lipid Research, Vol 48, Iss 1, Pp 235-241 (2007)

Profiling of leaf extracts from mutants of Arabidopsis with defects in lipid desaturation demonstrates the utility of collision-induced dissociation time-of-flight mass spectrometry (CID-TOF MS) for screening biological samples for fatty acid composi

Externí odkaz: https://doaj.org/article/fa93fb1ac33e4673a1b064f29263e465

Fatty Acid Composition by Total Acyl Lipid Collision-Induced Dissociation Time-of-Flight (TAL-CID-TOF) Mass Spectrometry

Autor: David K. Johnson, Ruth Welti, Paul Hinkes, Carl Fruehan, Pamela Tamura, Todd D. Williams

Publikováno v: Methods in Molecular Biology ISBN: 9781071613610
Methods Mol Biol

Total-acyl-lipid--collision induced dissociation--time-of-flight (TAL-CID-TOF) mass spectrometry uses a quadrupole--time-of-flight (QTOF) mass spectrometer to rapidly provide a comprehensive fatty acid composition of a biological lipid extract. Sampl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32960bcf1569fc19a3fa4ba151f401da
https://doi.org/10.1007/978-1-0716-1362-7_8

Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms

Autor: Ole N. Jensen, Todd D. Williams, Kevin Jeanne Dit Fouque, Alexandre A. Shvartsburg, Matthew A. Baird, Alyssa Garabedian, Jacob Porter, Pavel V. Shliaha, Francisco Fernandez-Lima

Publikováno v: Garabedian, A, Baird, M A, Porter, J, Jeanne Dit Fouque, K, Shliaha, P V, Jensen, O N, Williams, T D, Fernandez-Lima, F & Shvartsburg, A A 2018, ' Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms ', Analytical Chemistry, vol. 90, no. 4, pp. 2918-2925 . https://doi.org/10.1021/acs.analchem.7b05224

Comprehensive characterization of proteomes comprising the same proteins with distinct post-translational modifications (PTMs) is a staggering challenge. Many such proteoforms are isomers (localization variants) that require separation followed by to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f9942068e080cfdc95fba5397e072
https://doi.org/10.1021/acs.analchem.7b05224

Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection using MRI, NIRF, and Mass Spectrometry

Autor: Ngoc H. On, Teruna J. Siahaan, Paul Kiptoo, Donald W. Miller, Todd D. Williams, Kavisha R. Ulapane

Publikováno v: Nanotheranostics

There is an urgent need to develop new and alternative methods to deliver functional biomolecules to the brain for diagnosis and treatment of brain diseases. The goal of this study was to evaluate the activity of blood-brain barrier (BBB) modulators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620fdc82e82e7e583eed92f9a240f54c
https://doi.org/10.7150/ntno.19158

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues

Autor: Michael S. Wolfe, Sujan Devkota, Todd D. Williams

Publikováno v: The Journal of Biological Chemistry

Production of amyloid β-protein (Aβ) is carried out by the membrane-embedded γ-secretase complex. Mutations in the transmembrane domain of amyloid β-protein precursor (APP) associated with early-onset familial Alzheimer's disease (FAD) can alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a00aaf1d3eabc06d4d9ee9a56c13f13
https://doi.org/10.1016/j.jbc.2021.100281