Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion

Autor: Ruin Moaddel, Cristan A. Farmer, Mani Yavi, Bashkim Kadriu, Min Zhu, Jinshui Fan, Qinghua Chen, Elin Lehrmann, Giovanna Fantoni, Supriyo De, Caio H. Mazucanti, Elia E. Acevedo-Diaz, Peixiong Yuan, Todd D. Gould, Lawrence T. Park, Josephine M. Egan, Luigi Ferrucci, Carlos A. Zarate, Jr.

Publikováno v: iScience, Vol 26, Iss 12, Pp 108527- (2023)

Summary: Ketamine is a treatment for both refractory depression and chronic pain syndromes. In order to explore ketamine’s potential mechanism of action and whether ketamine or its metabolites cross the blood brain barrier, we examined the pharmaco

Externí odkaz: https://doaj.org/article/dd7ad1b3a925423d97ebe742d4f5433a

(R,S)-ketamine and (2R,6 R)-hydroxynorketamine differentially affect memory as a function of dosing frequency

Autor: Lace M. Riggs, Xiaoxian An, Edna F. R. Pereira, Todd D. Gould

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract A single subanesthetic infusion of ketamine can rapidly alleviate symptoms of treatment-resistant major depression. Since repeated administration is required to sustain symptom remission, it is important to characterize the potential untowar

Externí odkaz: https://doaj.org/article/3c665b6efe044095b2dd0e68c18d5190

Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor

Autor: Polymnia Georgiou, Panos Zanos, Ta-Chung M. Mou, Xiaoxian An, Danielle M. Gerhard, Dilyan I. Dryanovski, Liam E. Potter, Jaclyn N. Highland, Carleigh E. Jenne, Brent W. Stewart, Katherine J. Pultorak, Peixiong Yuan, Chris F. Powels, Jacqueline Lovett, Edna F. R. Pereira, Sarah M. Clark, Leonardo H. Tonelli, Ruin Moaddel, Carlos A. Zarate, Ronald S. Duman, Scott M. Thompson, Todd D. Gould

Publikováno v: Nat Neurosci

We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its bioactive metabolite (2R,6R)-hydroxynorketamine. Mice showed aversion to the scent of male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2785218ca391a1003e91994de1564c3
https://doi.org/10.1038/s41593-022-01146-x

Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

Autor: Naushaba Hasin, Lace M. Riggs, Tatyana Shekhtman, Justin Ashworth, Robert Lease, Rediet T. Oshone, Elizabeth M. Humphries, Judith A. Badner, Pippa A. Thomson, David C. Glahn, David W. Craig, Howard J. Edenberg, Elliot S. Gershon, Francis J. McMahon, John I. Nurnberger, Peter P. Zandi, John R. Kelsoe, Jared C. Roach, Todd D. Gould, Seth A. Ament

Publikováno v: Hasin, N, Riggs, L M, Shekhtman, T, Ashworth, J, Lease, R, Oshone, R T, Humphries, E M, Badner, J A, Thomson, P A, Glahn, D C, Craig, D W, Edenberg, H J, Gershon, E S, McMahon, F J, Nurnberger, J I, Zandi, P P, Kelsoe, J R, Roach, J C, Gould, T D & Ament, S A 2022, ' Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder ', Molecular Psychiatry . https://doi.org/10.1038/s41380-022-01609-4

Bipolar disorder is an often-severe mental health condition characterized by alternation between extreme mood states of mania and depression. Despite strong heritability and the recent identification of 64 common variant risk loci of small effect, pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c8a18f5ff2733bcbdb3547f088530f
https://doi.org/10.1038/s41380-022-01609-4

Possible psychedelic therapeutic mechanism

Autor: Evan M. Hess, Todd D. Gould

Publikováno v: Science. 379:642-643

Psychedelics act on intracellular serotonin receptors that are not accessible by serotonin alone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5337cbb77ace92e8a1419df77476e19
https://doi.org/10.1126/science.adg2989