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Akademický článek

Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer’s disease

Autor: Julian D. Dallmeier, Ryan Gober, Regina T. Vontell, Ayled Barreda, Daniel A. Dorfsman, David A. Davis, Xiaoyan Sun, Daniel Brzostowicki, Illiana Bennett, Susanna P. Garamszegi, Connor M. Wander, Todd Cohen, William K. Scott

Publikováno v: Frontiers in Neuroscience, Vol 18 (2024)

IntroductionSeverity and distribution of aggregated tau and neurofibrillary tangles (NFT) are strongly correlated with the clinical presentation of Alzheimer’s disease (AD). Clearance of aggregated tau could decrease the rate of NFT formation and d

Externí odkaz: https://doaj.org/article/d606ce4d937341f9881e87e417b730aa

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Akademický článek

Validation of the cell cycle progression score to differentiate indolent from aggressive prostate cancer in men diagnosed through transurethral resection of the prostate biopsy

Autor: Jack M. Cuzick, Steven Stone, Lauren Lenz, Darl D. Flake, Saradha Rajamani, Henrik Moller, Daniel Maurice Berney, Todd Cohen, Peter T. Scardino

Publikováno v: Cancer Reports, Vol 5, Iss 8, Pp n/a-n/a (2022)

Abstract Background Validation of biomarker‐based prognostic models to improve risk stratification in men with localized prostate cancer (PrCa) remains a clinical need. It has previously been shown that the cell cycle progression (CCP) test provide

Externí odkaz: https://doaj.org/article/7a27c92123b54b92a8b9551cefb4fd0c

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Akademický článek

Deceptive intracardiac electrograms during an ICD interrogation. A clinical challenge

Autor: Manish Undavia, Hejmadi Prabhu, Todd Cohen

Publikováno v: Indian Pacing and Electrophysiology Journal, Vol 16, Iss 1, Pp 32-33 (2016)

We present a case of a patient with significant structural heart disease from previous cardiac surgeries who presented for an electrophysiology study and radiofrequency ablation. The case highlights the significance of intra-atrial conduction delays

Externí odkaz: https://doaj.org/article/b8ed92e0f2014ec7a104bda2407bdc80

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RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

Autor: Julie Necarsulmer, Jeremy Simon, Baggio Evangelista, Youjun Chen, Xu Tian, Sara Nafees, Ariana Marquez Gonzalez, Ping Wang, Deepa Ajit, Viktoriya Nikolova, Kathryn Harper, Jennifer Ezzell, Adriana Beltran, Sheryl Moy, Todd Cohen

TDP-43 proteinopathies including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by aggregation and mislocalization of the nucleic-acid binding protein TDP-43 and subsequent n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba68108cac5400c52771fecf51c3770
https://doi.org/10.7554/elife.85921

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Development and validation of a cell cycle progression signature for decentralized testing of men with prostate cancer

Publikováno v: Biomarkers in Medicine. 16:449-459

Aim: The 46-gene Prolaris® cell cycle progression test provides information on the risk of prostate cancer progression. Here we developed and validated a 16-gene kit-based version. Methods: RNA was extracted from prostate cancer biopsy tissue. Ampli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9221b626ba4da981a90d2da19496401c
https://doi.org/10.2217/bmm-2021-0479

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Validation of the cell cycle progression score to differentiate indolent from aggressive prostate cancer in men diagnosed through transurethral resection of the prostate biopsy

Autor: Saradha Rajamani, Todd Cohen, Lauren Lenz, Steven Stone, Daniel M. Berney, Peter T. Scardino, Henrik Møller, Darl D. Flake, Jack Cuzick

Publikováno v: Cancer Reports. 5

Background Validation of biomarker-based prognostic models to improve risk stratification in men with localized prostate cancer (PrCa) remains a clinical need. It has previously been shown that the cell cycle progression (CCP) test provides significa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c8aef138694b90d6b5e6a15bce6870
https://doi.org/10.1002/cnr2.1535

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