Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Todd C Hollon"'
Autor:
Siri Sahib S Khalsa, Todd C Hollon, Arjun Adapa, Esteban Urias, Sudharsan Srinivasan, Neil Jairath, Julianne Szczepanski, Peter Ouillette, Sandra Camelo-Piragua, Daniel A Orringer
Publikováno v:
CNS Oncology, Vol 9, Iss 2 (2020)
The discovery of a new mass involving the brain or spine typically prompts referral to a neurosurgeon to consider biopsy or surgical resection. Intraoperative decision-making depends significantly on the histologic diagnosis, which is often establish
Externí odkaz:
https://doaj.org/article/23227fb891224a6c8bc49a555ee23655
Autor:
Haley K. Talbot-Stetsko, Todd C. Hollon, Cormac O. Maher, Aditya S. Pandey, Siri Sahib S. Khalsa
Publikováno v:
World Neurosurgery: X, Vol 19, Iss , Pp 100181- (2023)
Background: Guidelines for determining shunt dependence after aneurysmal subarachnoid hemorrhage (aSAH) remain unclear. We previously demonstrated change in ventricular volume (VV) between head CT scans taken pre- and post-EVD clamping was predictive
Externí odkaz:
https://doaj.org/article/67820da853a14f088dc76ba7eaa94958
Autor:
Andrea Comba, Maria Luisa Varela, Syed M. Faisal, Clifford C. Abel, II, Anna E. Argento, Wajd N. Al-Holou, Todd C. Hollon, Jacqueline D. Perelman, Patrick J. Dunn, Sebastien Motsch, Maria G. Castro, Pedro R. Lowenstein
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102174- (2023)
Summary: Development of spatial-integrative pre-clinical models is needed for glioblastoma, which are heterogenous tumors with poor prognosis. Here, we present an optimized protocol to generate three-dimensional ex vivo explant slice glioma model fro
Externí odkaz:
https://doaj.org/article/2c43e2be55634ce0ab0275ab171a6f0b
Autor:
Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman, Andrew P. Lieberman
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-18 (2019)
Abstract Background Niemann–Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this diso
Externí odkaz:
https://doaj.org/article/e83baffb0e3847bbafc88e3c4bd749f6
Autor:
Todd C. Hollon, Daniel A. Orringer
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
We recently developed and validated a bedside tissue-to-diagnosis pipeline using stimulated Raman histology (SRH), a label-free optical imaging method, and deep convolutional neural networks (CNN) in prospective clinical trial. Our CNN learned a hier
Externí odkaz:
https://doaj.org/article/0d6c10081cd34199a9f07ddf68757fa2
Autor:
Daniel A. Orringer, Sandra Camelo-Piragua, Karin Muraszko, Andrew P. Lieberman, Matija Snuderl, Kathryn McFadden, Cormac O. Maher, Hugh Garton, Mia R. Garrard, Yashar S. Niknafs, Balaji Pandian, Spencer Lewis, Todd C. Hollon
Random forest model 2. A) Example decision tree from random forest model 2. B) Out-of-bag, low-grade, and high-grade tumor classification error across 500 grown decision trees. C) Image feature importance for model 2. Similar to model 1, nuclei densi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512d76e580a5a08f7d2617c78e0b2805
https://doi.org/10.1158/0008-5472.22417835
https://doi.org/10.1158/0008-5472.22417835
Autor:
Daniel A. Orringer, Sandra Camelo-Piragua, Karin Muraszko, Andrew P. Lieberman, Matija Snuderl, Kathryn McFadden, Cormac O. Maher, Hugh Garton, Mia R. Garrard, Yashar S. Niknafs, Balaji Pandian, Spencer Lewis, Todd C. Hollon
Accurate histopathologic diagnosis is essential for providing optimal surgical management of pediatric brain tumors. Current methods for intraoperative histology are time- and labor-intensive and often introduce artifact that limit interpretation. St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d67647606d98bed215bf462044e10d
https://doi.org/10.1158/0008-5472.c.6509957
https://doi.org/10.1158/0008-5472.c.6509957
Autor:
Daniel A. Orringer, Sandra Camelo-Piragua, Karin Muraszko, Andrew P. Lieberman, Matija Snuderl, Kathryn McFadden, Cormac O. Maher, Hugh Garton, Mia R. Garrard, Yashar S. Niknafs, Balaji Pandian, Spencer Lewis, Todd C. Hollon
Random forest model 1. A) Example decision tree from random forest model 1. B) Out-of-bag, normal tissue, and tumor tissue classification error across 500 grown decision trees. C) Image feature importance for model 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568bfb83cef2153b330954ec0c90195d
https://doi.org/10.1158/0008-5472.22417838.v1
https://doi.org/10.1158/0008-5472.22417838.v1
Autor:
Daniel A. Orringer, Sandra Camelo-Piragua, Karin Muraszko, Andrew P. Lieberman, Matija Snuderl, Kathryn McFadden, Cormac O. Maher, Hugh Garton, Mia R. Garrard, Yashar S. Niknafs, Balaji Pandian, Spencer Lewis, Todd C. Hollon
Pipeline information from CellProfiler feature extraction method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3922781d411a7560822d610971ff4fea
https://doi.org/10.1158/0008-5472.22417832.v1
https://doi.org/10.1158/0008-5472.22417832.v1
Autor:
Kristen D. Raue, Aditya S. Pandey, David B. Altshuler, Cormac O. Maher, Haley K. Talbot-Stetsko, Bryan L. Aaron, Siri Sahib S Khalsa, Sudharsan Srinivasan, Todd C. Hollon, Arjun R. Adapa
Publikováno v:
World Neurosurgery. 157:e57-e65
Hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH) that often requires acute placement of an external ventricular drain (EVD). The current systems available for determining which patients will require long-term cerebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef60bafd9198b9df7717ece5c4fc3018
https://doi.org/10.1016/j.wneu.2021.09.085
https://doi.org/10.1016/j.wneu.2021.09.085