Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Todd C Appleby"'
Autor:
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M Brendza, Todd C Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H Tay, William E Delaney, Gregory T Notte, Uli Schmitz, Becket Feierbach
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0271145 (2022)
Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis B virus (HBV) infection, we performed a focused screen of epigenet
Externí odkaz:
https://doaj.org/article/f4644c5b4458489dba69140ec4acc22c
Autor:
Brandon F. Malone, Jason K. Perry, Paul Dominic B. Olinares, Hery W. Lee, James Chen, Todd C. Appleby, Joy Y. Feng, John P. Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y. D. Chua, Joshua H. Mendez, Ed T. Eng, Robert Landick, Matthias Götte, Brian T. Chait, Elizabeth A. Campbell, Seth A. Darst
Publikováno v:
Nature. 614:781-787
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1e3a0afe376b3213937aceab8ce1b03
https://doi.org/10.1038/s41586-022-05664-3
https://doi.org/10.1038/s41586-022-05664-3
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5892a90808b40581a09439f9529aaaa6
https://doi.org/10.1038/s41586-020-2443-1
https://doi.org/10.1038/s41586-020-2443-1
Autor:
Devleena Shivakumar, Uli Schmitz, Janet L. Paulsen, Todd C. Appleby, Daniel J. Sindhikara, Armando G. Villaseñor, Lingle Wang, Haoyu S. Yu
Publikováno v:
Journal of Chemical Information and Modeling. 60:3489-3498
A tremendous research and development effort was exerted toward combating chronic hepatitis C, ultimately leading to curative oral treatments, all of which are targeting viral proteins. Despite the advantage of numerous targets allowing for broad hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ecd1ecff94a2e26eab277b9117a618
https://doi.org/10.1021/acs.jcim.0c00132
https://doi.org/10.1021/acs.jcim.0c00132
Autor:
Kyla Ramey, Katana Ashley Anne, Kato Darryl, Tran Chinh Viet, Cheng Y. Yang, Link John O, Debi Jin, Yujin Wang, Kobayashi Tetsuya, Karki Kapil Kumar, Armando G. Villaseñor, Todd C. Appleby, Kelly Wang, Sangi Michael, Jeff Zablocki, Randy Vivian, Brian E. Schultz, Yang Zheng-Yu, Guofeng Cheng, Dustin Siegel, Zipfel Sheila, Ona Barauskas, James G. Taylor, Martinez Ruben, Katie Chan, Adam J. Schrier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2428-2436
Treatment of hepatitis C virus (HCV) infection has been historically challenging due the high viral genetic complexity wherein there are eight distinct genotypes and at least 86 viral subtypes. While HCV NS3/4A protease inhibitors are an established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210d14a9952795cbbb25c9ee4809cc66
https://doi.org/10.1016/j.bmcl.2019.03.037
https://doi.org/10.1016/j.bmcl.2019.03.037
Autor:
Ruth Wang, Sarah Wise, Ben Niu, Todd C. Appleby, Michael L. Gross, Melanie Wong, Giuseppe A. Papalia, Jean-Philippe Belzile, Sheila Clancy, Latesh Lad, Armando G. Villaseñor, Johannes Voight, Mariya Morar, Katherine M. Brendza
Publikováno v:
Biochemistry
Blocking interactions between PD-1 and PD-L1 opens a new era of cancer treatment involving immunity modulation. Although most immunotherapies use monoclonal antibodies, small-molecule inhibitors offer advantages. To facilitate development of small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8574553f47281704646a2b2cf091a18
https://pubmed.ncbi.nlm.nih.gov/31841311
https://pubmed.ncbi.nlm.nih.gov/31841311
Autor:
Jean-Yves Christophe Chiva, Peter Pyun, Andrew John Keats, Linos Lazarides, Karine G. Poullennec, Neil Andrew Dunbar, Brian E. Schultz, Mingzhe Ji, Gregory M. Watt, Karki Kapil Kumar, Ruby Cai, Carina E. Cannizzaro, Uli Schmitz, David Kenneth Dean, Yu-Jen Lee, Sangi Michael, Victoria Alexandra Steadman, Adam J. Schrier, Simon B. Pettit, Hans G. Fliri, Adrian John Highton, Todd C. Appleby, Carol Austin, Richard L. Mackman, Caroline A. Blakemore, Hui Hon Chung, Dustin Siegel, Gregory Chin, Bernard P. Murray, Hai Yang, Yang Tian, George Stepan, Jonathan Sanvoisin, Albert Liclican, Mish Michael R, David Sperandio, Rex Santos, Petr Jansa, Haolun Jin
Publikováno v:
Journal of Medicinal Chemistry. 61:9473-9499
Cyclophilins are a family of peptidyl-prolyl isomerases that are implicated in a wide range of diseases including hepatitis C. Our aim was to discover through total synthesis an orally bioavailable, non-immunosuppressive cyclophilin (Cyp) inhibitor w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f349698a38c7c9924d318620a6fcc5d2
https://doi.org/10.1021/acs.jmedchem.8b00802
https://doi.org/10.1021/acs.jmedchem.8b00802
Autor:
Elizabeth A. Campbell, Uli Schmitz, John P. Bilello, Joy Y. Feng, Jason K. Perry, Todd C. Appleby
Publikováno v:
The Journal of Biological Chemistry
Using available cryo-EM and x-ray crystal structures of the nonstructural proteins that are responsible for SARS-CoV-2 viral RNA replication and transcription, we have constructed an atomistic model of how the proteins assemble into a functioning sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777a54a79a0edaa70eacb7b025c6ab0e
https://doi.org/10.1016/j.jbc.2021.101218
https://doi.org/10.1016/j.jbc.2021.101218
Autor:
Yu-Jen Lee, Andrew John Keats, Karine G. Poullennec, Uli Schmitz, Todd C. Appleby, Hans G. Fliri, Linos Lazarides, Albert Liclican, Steven J. Stanway, David Kenneth Dean, Debi Jin, Victoria Alexandra Steadman, Simon B. Pettit, Stephanie A. Leavitt, Yang Tian, Jonathan Sanvoisin, Petr Jansa, Brian E. Schultz, Christian R. Frey, Melanie H. Wong, Gregory M. Watt, Richard L. Mackman, Carol Austin
Publikováno v:
Journal of Medicinal Chemistry. 60:1000-1017
Cyclophilin inhibition has been a target for the treatment of hepatitis C and other diseases, but the generation of potent, drug-like molecules through chemical synthesis has been challenging. In this study, a set of macrocyclic cyclophilin inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091df6df2743a293d5a795f54f7981a6
https://doi.org/10.1021/acs.jmedchem.6b01329
https://doi.org/10.1021/acs.jmedchem.6b01329
Autor:
Todd C. Appleby, Ruth Wang, Magdeleine Hung, Brian E. Schultz, Roman Sakowicz, Armando G. Villaseñor, Giuseppe A. Papalia, Maile Velasquez, Xiaohong Liu, Victoria C. Smith, Andrew E. Greenstein, Hyock Joo Kwon, Melanie H. Wong, Albert Liclican
Publikováno v:
The Journal of biological chemistry. 292(16)
Matrix metalloproteinase 9 (MMP9) is a member of a large family of proteases that are secreted as inactive zymogens. It is a key regulator of the extracellular matrix, involved in the degradation of various extracellular matrix proteins. MMP9 plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f99c41e438cdd9e0534167e54a63aa
https://pubmed.ncbi.nlm.nih.gov/28235803
https://pubmed.ncbi.nlm.nih.gov/28235803