Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Todd C, Holmes"'
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Novel brain clearing methods revolutionize imaging by increasing visualization throughout the brain at high resolution. However, combining the standard tool of immunostaining targets of interest with clearing methods has lagged behind. We integrate w
Externí odkaz:
https://doaj.org/article/daa2c9602e2c410292aab2735c62e21a
Autor:
Hai Zhang, Rachita K. Sumbria, Rudy Chang, Jiahong Sun, David H. Cribbs, Todd C. Holmes, Mark J. Fisher, Xiangmin Xu
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Cerebral microhemorrhages (CMH) are associated with stroke, cognitive decline, and normal aging. Our previous study shows that the interaction between oxidatively stressed red blood cells (RBC) and cerebral endothelium may underli
Externí odkaz:
https://doaj.org/article/348c92fd4f674ca2add361badcf21756
Autor:
Zhiqun Tan, B. Maximiliano Garduño, Pedro Fernández Aburto, Lujia Chen, Nicole Ha, Patricia Cogram, Todd C. Holmes, Xiangmin Xu
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-23 (2022)
Abstract The long-lived Chilean rodent (Octodon degus) has been reported to show spontaneous age-dependent neuropathology and cognitive impairments similar to those observed in human AD. However, the handful of published papers on degus of differing
Externí odkaz:
https://doaj.org/article/3a9886ab7b724ed1abd9fc6cda0f43e4
Autor:
Feng Xiong, Hong Yang, Yi-Ge Song, Hai-Bin Qin, Qing-Yang Zhang, Xian Huang, Wei Jing, Manfei Deng, Yang Liu, Zhixiang Liu, Yin Shen, Yunyun Han, Youming Lu, Xiangmin Xu, Todd C. Holmes, Minmin Luo, Fei Zhao, Min-Hua Luo, Wen-Bo Zeng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Minimizing toxicity of herpes simplex virus 1 (HSV) based tools for anterograde tracing is important for functional studies. Here the authors generate an anterograde monosynaptic tracer system based on HSV amplicon, which shows fast tracing, bright l
Externí odkaz:
https://doaj.org/article/50eb8b5789094e9fb35682cd909e2b83
Autor:
David D. Au, Jenny C. Liu, Soo Jee Park, Thanh H. Nguyen, Mia Dimalanta, Alexander J. Foden, Todd C. Holmes
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Lateral ventral neurons (LNvs) in the fly circadian neural circuit mediate behaviors other than clock resetting, including light-activated acute arousal. Converging sensory inputs often confer functional redundancy. The LNvs have three distinct light
Externí odkaz:
https://doaj.org/article/d784710cfb024a97868c667e523757a8
Autor:
Lujia Chen, Xiaoxiao Lin, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106703- (2023)
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippoca
Externí odkaz:
https://doaj.org/article/9d92c0cd42944b678ccdd98f426621bd
Publikováno v:
Neurobiology of Stress, Vol 23, Iss , Pp 100527- (2023)
The anterior portion of the bed nucleus of the stria terminalis (BNST) modulates fear and stress responses. The anterodorsal BNST (adBNST) can be anatomically subdivided further into the lateral and medial divisions. Although output projections of BN
Externí odkaz:
https://doaj.org/article/75adfc267425433ea0cb722091f68203
Autor:
Xiaoxiao Lin, Lujia Chen, Amandine Jullienne, Hai Zhang, Arjang Salehi, Mary Hamer, Todd C. Holmes, Andre Obenaus, Xiangmin Xu
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract Acquired brain injuries due to trauma damage the cortical vasculature, which in turn impairs blood flow to injured tissues. There are reports of vascular morphological recovery following traumatic brain injury, but the remodeling process has
Externí odkaz:
https://doaj.org/article/7ce0eb24d94a412f8b9d6846e9f40e7f
Autor:
Hai Zhang, Lujia Chen, Kevin G. Johnston, Joshua Crapser, Kim N. Green, Nicole My-Linh Ha, Andrea J. Tenner, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105939- (2023)
A key challenge in developing diagnosis and treatments for Alzheimer's disease (AD) is to detect abnormal network activity at as early a stage as possible. To date, behavioral and neurophysiological investigations in AD model mice have yet to conduct
Externí odkaz:
https://doaj.org/article/94f303bca8164062b3c45e8aa6ad71c0
Autor:
David D. Au, Jenny C. Liu, Thanh H. Nguyen, Alexander J. Foden, Soo Jee Park, Mia Dimalanta, Zhaoxia Yu, Todd C. Holmes
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Nocturnal Anopheles mosquitoes exhibit strong behavioral avoidance to blue-light while diurnal Aedes mosquitoes are behaviorally attracted to blue-light and a wide range of other wavelengths of light. To determine the molecular mechanism of these eff
Externí odkaz:
https://doaj.org/article/d165e7e5cf60425b8af654cd7ee856e3