Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Todd Ashworth"'
Autor:
Michael J Kluk, Todd Ashworth, Hongfang Wang, Birgit Knoechel, Emily F Mason, Elizabeth A Morgan, David Dorfman, Geraldine Pinkus, Oliver Weigert, Jason L Hornick, Lucian R Chirieac, Michelle Hirsch, David J Oh, Andrew P South, Irene M Leigh, Celine Pourreyron, Andrew J Cassidy, Daniel J Deangelo, David M Weinstock, Ian E Krop, Deborah Dillon, Jane E Brock, Alexander J F Lazar, Myron Peto, Raymond J Cho, Alexander Stoeck, Brian B Haines, Sriram Sathayanrayanan, Scott Rodig, Jon C Aster
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67306 (2013)
Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking. Here, we bridge this gap
Externí odkaz:
https://doaj.org/article/32604a8825f6402bb5ed46051a8c0b7c
Autor:
Wendy R Gordon, Didem Vardar-Ulu, Sarah L'Heureux, Todd Ashworth, Michael J Malecki, Cheryll Sanchez-Irizarry, Debbie G McArthur, Gavin Histen, Jennifer L Mitchell, Jon C Aster, Stephen C Blacklow
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6613 (2009)
Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the re
Externí odkaz:
https://doaj.org/article/bd8fa4227a984c5fb57219385262de3b
Autor:
Jon C. Aster, Hongfang Wang, Jernej Godec, Todd Ashworth, James E. Bradner, Michael J. Kluk, Gerard I. Evan, Christopher A. French, Michael J. Cameron, Alexandra B. Aserlind, Jessica M Ambrose, Adlai R. Grayson, Erica M. Walsh
Publikováno v:
Oncogene. 33:1736-1742
NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins that block differentiation and maintain tumor growth. BRD-NUT oncoproteins contai
Autor:
Jon C. Aster, Hongfang Wang, Elliott Kieff, James Zou, Bradley E. Bernstein, Bo Zhao, Hoifung Wong, Todd Ashworth, Warren S. Pear, Jonathan Schug, Stephen C. Blacklow, Eric Johannsen, Kelly L. Arnett
Publikováno v:
Proceedings of the National Academy of Sciences. 108:14908-14913
Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T-cell progenitors. Using ChIP-Seq, we find that in human and murine T-lymphoblastic leukemia (TLL) genomes Notch1 binds preferentia
Autor:
Jon C. Aster, Michelle A. Kelliher, Mark Y. Chiang, Lanwei Xu, Susan Chan, Philippe Kastner, Stephen C. Blacklow, Jérôme Mastio, Todd Ashworth, Warren S. Pear
Publikováno v:
Blood. 116:5455-5464
Point mutations that trigger ligand-independent proteolysis of the Notch1 ectodomain occur frequently in human T-cell acute lymphoblastic leukemia (T-ALL) but are rare in murine T-ALL, suggesting that other mechanisms account for Notch1 activation in
Autor:
Ananda L. Roy, Todd Ashworth
Publikováno v:
The Journal of Immunology. 178:2631-2635
The multifunctional transcription factor TFII-I physically and functionally interacts with Bruton’s tyrosine kinase in murine B cells. However, the downstream functions of TFII-I in B cells are unknown. Toward achieving this goal, we established st
Autor:
Michael Witcher, Amine Saad, Todd Ashworth, Sonia V. del Rincón, Khalid Hilmi, Maud Marques, Moulay A. Alaoui-Jamali, Rodrigo Peña-Hernández, Ananda L. Roy, Beverly M. Emerson, Teijun Zhao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(7)
CCCTC-binding factor (CTCF) is a key regulator of nuclear chromatin structure and gene regulation. The impact of CTCF on transcriptional output is highly varied, ranging from repression to transcriptional pausing and transactivation. The multifunctio
Autor:
Jon C. Aster, Ian E. Krop, Irene M. Leigh, Sriram Sathayanrayanan, Michael J. Kluk, Brian B. Haines, Michelle S. Hirsch, Elizabeth A. Morgan, Todd Ashworth, Deborah A. Dillon, Alexander Stoeck, Andrew Cassidy, Raymond J. Cho, David J. Oh, Celine Pourreyron, Myron Peto, Hongfang Wang, Jason L. Hornick, Oliver Weigert, Geraldine S. Pinkus, Jane E. Brock, Andrew P. South, David M. Dorfman, Daniel J. DeAngelo, Birgit Knoechel, Scott J. Rodig, Emily F. Mason, Lucian R. Chirieac, Alexander J. Lazar, David M. Weinstock
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67306 (2013)
PLoS ONE
PLoS ONE
Fixed, paraffin-embedded (FPE) tissues are a potentially rich resource for studying the role of NOTCH1 in cancer and other pathologies, but tests that reliably detect activated NOTCH1 (NICD1) in FPE samples have been lacking. Here, we bridge this gap
Autor:
Jon C. Aster, Kathleen Cullion, Jessica Tatarek, Michelle A. Kelliher, Todd Ashworth, Rachel M. Gerstein
Publikováno v:
Blood. 118(6)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy largely caused by aberrant activation of the TAL1/SCL, LMO1/2, and NOTCH1 oncogenes. Approximately 30% of T-ALL patients relapse, and evidence is emerging that relapse may result
Autor:
Stéphanie Le Gras, Jérôme Mastio, Jacques Ghysdael, Freddy Radtke, Thomas Gridley, Robin Jeannet, Jon C. Aster, Alejandra Macias-Garcia, Susan Chan, Attila Oravecz, Bernard Jost, Anne-Solen Geimer Le Lay, Tasuku Honjo, Todd Ashworth, Philippe Kastner
The Notch pathway is frequently activated in T-cell acute lymphoblastic leukemias (T-ALLs). Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 is expressed in all T-ALLs, but it is currently unclear how thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bd54984e30ae8c8a3509bbe6c61e2c
https://europepmc.org/articles/PMC3100247/
https://europepmc.org/articles/PMC3100247/