Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Todd Andrew Blumenkopf"'
Autor:
Brett M. Lillie, Matthew Frank Brown, Bret D. Perry, Mark Edward Flanagan, Chakrapani Subramanyam, Kudlacz Elizabeth M, Jianmin Sun, Michael B. Fisher, Todd Andrew Blumenkopf, Chang Shang-Poa, Perry S. Sawyer, Timothy J. Strelevitz, Sandra P. McCurdy, William H. Brissette, Craig R. Kent, Paul S. Changelian, Jonathan L. Doty, Michael John Munchhof, David A Whipple, Jeffrey M. Casavant, Michael Hines, Kelly S. Magnuson, Eileen A. Elliott
Publikováno v:
Journal of Medicinal Chemistry. 53:8468-8484
There is a critical need for safer and more convenient treatments for organ transplant rejection and autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases (JAK1, JAK3) are expressed in lymphoid cells and are involved in the signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8b2178a892e219d40a9e1abea75681
https://doi.org/10.1021/jm1004286
https://doi.org/10.1021/jm1004286
Autor:
Deborah Finco-Kent, Panayiotis Zagouras, James F. Smith, Kwansik Yoon, Douglas A. Fisher, Randall E. Morris, Jeffrey M. Casavant, Eileen A. Elliott, Dominic C. Borie, William H. Martin, Craig R. Kent, Paul S. Changelian, Linda F. Nelms, John J. O'Shea, Bonnie J. Rizzuti, Anthony J. Milici, Sandra P. McCurdy, Bret D. Perry, Todd Andrew Blumenkopf, Michael John Munchhof, John P. Higgins, Ming-Sing Si, Michael J Larson, William H. Brissette, Chakrapani Subramanyam, Thasia G. Woodworth, Timothy J. Strelevitz, John L. Doty, Bari Holm, Mark Edward Flanagan, Mary Josephine Saltarelli, Gretchen E Beckius, Chunyan Su, Ricardo T. Paniagua, Michael Hines, Chan R. Beals, Johnson Kimberly Sue, Maryrose J. Conklyn, Bruce H. Littman, Kelly S. Magnuson, Holly A. Magna, Perry S. Sawyer, Bruce A. Reitz, Brett M. Lillie, Lisa S. Hayes, Kudlacz Elizabeth M, David A. Whipple, James D. Moyer, Erika R. Koslov, Jianmin Sun, Matthew Frank Brown, Anderson See Gaweco, Yong Jie Zhou, Chang Shang-Poa, Deanna L. Baker, Thomas T. Kawabata, Shelley G. des Etages, Michael B. Fisher, Douglas J. Ball
Publikováno v:
Science. 302:875-878
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea15b17ccaadc6b33998089ee820ac1d
https://doi.org/10.1126/science.1087061
https://doi.org/10.1126/science.1087061
Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine
Autor:
Wilcox Glenn Ernest, Weiling Cai, Mark Edward Flanagan, Stefan Abele, Jeffrey M. Casavant, Mike Munchhoff, David H. Brown Ripin, Ton Vries, David A. Whipple, Kees Pouwer, Cliff Meltz, Jianmin Sun, Keith E. McCarthy, Klaus Laue, John J. Teixeira, Christian Koecher, Jonathan L. Doty, Bharat Kiritkumar Shah, Todd Andrew Blumenkopf
Publikováno v:
Organic Process Research & Development. 7:115-120
The synthesis of cis-N-benzyl-3-methylamino-4-methylpiperidine (5) via hydroboration of tetrahydropyridine 3 followed by oxidation and reductive amination was optimized and scaled up to produce 10-kg quantities of product. Three routes to 3 were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4c02f223cd1ebe05d57ff7969d746b
https://doi.org/10.1021/op025599x
https://doi.org/10.1021/op025599x
Autor:
Todd Andrew Blumenkopf, Jorge Gallo, Linda Mileshkin, Jonathan H. Goldman, Sheree Darang, Lee S. Rosen, S. Gail Eckhardt, Diane Wang, Aurora Breazna
Publikováno v:
Molecular Cancer Therapeutics. 10:A177-A177
Background: P21 activated kinase (PAK), a family of serine-threonine kinases, is a downstream effector of the Rho family and functions as a signaling node for various oncogenic pathways. The capability to transform cell cultures and the consistent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d16f92908cdc6c37e483af72315b014
https://doi.org/10.1158/1535-7163.targ-11-a177
https://doi.org/10.1158/1535-7163.targ-11-a177