Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Todd A. Wyatt"'
Autor:
Aaron D. Schwab, Todd A. Wyatt, Grace Moravec, Geoffrey M. Thiele, Amy J. Nelson, Angela Gleason, Oliver Schanze, Michael J. Duryee, Debra J. Romberger, Ted R. Mikuls, Jill A. Poole
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet
Externí odkaz:
https://doaj.org/article/679f8daa696f4b38867233ba2722837f
Autor:
Amber N. Johnson, John Dickinson, Amy Nelson, Rohit Gaurav, Katrina Kudrna, Scott E. Evans, Katherine Janike, Todd A. Wyatt, Jill A. Poole
Publikováno v:
Journal of Immunotoxicology, Vol 20, Iss 1 (2023)
AbstractThe Toll-like receptor (TLR) adaptor protein MyD88 is integral to airway inflammatory response to microbial-enriched organic dust extract (ODE) exposures. ODE-induced airway neutrophil influx and release of pro-inflammatory cytokines was esse
Externí odkaz:
https://doaj.org/article/2c6de4d6bccc4edbb7e6d3dcb407396e
Autor:
Kristi J. Warren, Cassandra Deering-Rice, Tom Huecksteadt, Shubhanshi Trivedi, Alessandro Venosa, Christopher Reilly, Karl Sanders, Frederic Clayton, Todd A. Wyatt, Jill A. Poole, Nicola M. Heller, Daniel Leung, Robert Paine
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-17 (2023)
Highlights Steady levels of estrogen are associated with changes in allergic inflammation. When E2 is maintained at a level comparable to the mid-follicular phase of ovulation mucus production and airway hyperreactivity are increased. Estrogen reduce
Externí odkaz:
https://doaj.org/article/aae9a7bfdacf4c79abae740cad18bcf2
Autor:
Aaron D. Schwab, Todd A. Wyatt, Amy J. Nelson, Angela Gleason, Rohit Gaurav, Debra J. Romberger, Jill A. Poole
Publikováno v:
Journal of Immunotoxicology, Vol 21, Iss 1 (2024)
AbstractEfficacious therapeutic options capable of resolving inflammatory lung disease associated with environmental and occupational exposures are lacking. This study sought to determine the preclinical therapeutic potential of lung-delivered recomb
Externí odkaz:
https://doaj.org/article/2822d7a139e442fb86e7176047ee803e
Autor:
Jill A. Poole, Rohit Gaurav, Aaron Schwab, Amy J. Nelson, Angela Gleason, Debra J. Romberger, Todd A. Wyatt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Although lung diseases typically result from long-term exposures, even a robust, one-time exposure can result in long-lasting consequences. Endotoxin is a ubiquitous environmental/occupational inflammatory agent often used to model airway in
Externí odkaz:
https://doaj.org/article/d9e34725e3f947fca0ec69cbdd3492d4
Autor:
Jill A. Poole, Ted R. Mikuls, Geoffrey M. Thiele, Rohit Gaurav, Amy J. Nelson, Michael J. Duryee, Ananya Mitra, Carlos Hunter, Todd A. Wyatt, Bryant R. England, Dana P. Ascherman
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Immunogenetic as well as environmental and occupational exposures have been linked to the development of rheumatoid arthritis (RA), RA-associated lung disease, and other primary lung disorders. Importantly, various inhalants can trigger post
Externí odkaz:
https://doaj.org/article/6715afcf5ca64ddfa7c719475c176126
Autor:
Kelly C. Cunningham, Deandra R. Smith, Daniel N. Villageliú, Christi M. Ellis, Amanda E. Ramer-Tait, Jeffrey D. Price, Todd A. Wyatt, Daren L. Knoell, Mystera M. Samuelson, Patricia E. Molina, David A. Welsh, Derrick R. Samuelson
Publikováno v:
Cells, Vol 12, Iss 18, p 2267 (2023)
Preclinical studies have shown that chronic alcohol abuse leads to alterations in the gastrointestinal microbiota that are associated with behavior changes, physiological alterations, and immunological effects. However, such studies have been limited
Externí odkaz:
https://doaj.org/article/a8b96d662ac14c31a8d5d2a677a403f0
Autor:
Kristi J. Warren, Jill A. Poole, Jenea M. Sweeter, Jane M. DeVasure, John D. Dickinson, R. Stokes Peebles, Todd A. Wyatt
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Respiratory viral infections are one of the leading causes of need for emergency care and hospitalizations in asthmatic individuals, and airway-secreted cytokines are released within hours of viral infection to initiate these exac
Externí odkaz:
https://doaj.org/article/d242a10aeb944bf08e9f3b0d2422c32b
Autor:
Claire G. Nissen, Deanna D. Mosley, Kusum K. Kharbanda, Dawn M. Katafiasz, Kristina L. Bailey, Todd A. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alcohol consumption with concurrent cigarette smoking produces malondialdehyde acetaldehyde (MAA)-adducted lung proteins. Lung surfactant protein D (SPD) supports innate immunity via bacterial aggregation and lysis, as well as by enhancing macrophage
Externí odkaz:
https://doaj.org/article/a0a9793bc7f24303b14a98e0e7265aa6
Autor:
Abenaya Muralidharan, Christopher D. Bauer, Dawn M. Katafiasz, Heather M. Strah, Aleem Siddique, St Patrick Reid, Kristina L. Bailey, Todd A. Wyatt
Publikováno v:
Pathogens, Vol 12, Iss 3, p 498 (2023)
Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can have a significant impact on immunity against pathogens. Here, we st
Externí odkaz:
https://doaj.org/article/3b3107cf11284c5e891c15dd3386f4de