Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Todd A. Verdoorn"'
Autor:
Michelle Alexander-Curtis, Rick Pauls, Julie Chao, John J Volpi, Philip M Bath, Todd A. Verdoorn
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Acute ischemic stroke (AIS) remains a major cause of death and disability throughout the world. The most severe form of stroke results from large vessel occlusion of the major branches of the Circle of Willis. The treatment strategies currently avail
Externí odkaz:
https://doaj.org/article/e56fc0ef35aa4b8f84cc544401a90e34
Autor:
Li Zhang, Robin Schwartz-Byrne, Steven Gertz, Matthew McGuire, Colleen Woodhouse, Brianna Powell, Min Wei, Chao Li, Clare B. Billing, Todd A. Verdoorn, Leslie Lam, Tom J. Parry, Benjamin Buller, Zheng Gang Zhang, David Poulsen, Michael Chopp
Publikováno v:
Stroke. 53:3455-3464
Background: Ischemic stroke affects about 700 000 patients per year in the United States, and to date, there are no effective pharmacological agents that promote recovery. Here, we studied the pharmacokinetics, pharmacodynamics, and efficacy of NTS-1
Autor:
Todd A. Verdoorn, Julie Chao, John Volpi, Michelle Alexander-Curtis, Rick Pauls, Philip M.W. Bath
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Therapeutic Advances in Neurological Disorders
Therapeutic Advances in Neurological Disorders
Acute ischemic stroke (AIS) remains a major cause of death and disability throughout the world. The most severe form of stroke results from large vessel occlusion of the major branches of the Circle of Willis. The treatment strategies currently avail
Autor:
David Smith, James Loy, Joseph P. Hendrick, Kevin M. Felsenstein, Barbara J. Robertson, Jeffery J. Anderson, Jason A. Corsa, Ming Zheng, Benito Munoz, Donna M. Barten, Steven Hansel, Todd A Verdoorn, Valerie Guss, Alice T. Loo, Rex Denton, Craig Polson, Kumar Srinivasan, Jian Wang, Susan B. Roberts, Bowei Wang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:635-643
gamma-Secretase inhibitors are one promising approach to the development of a therapeutic for Alzheimer's disease (AD). gamma-Secretase inhibitors reduce brain beta-amyloid peptide (Abeta), which is believed to be a major contributor in the etiology
Publikováno v:
Neuroscience Research Communications. 32:143-150
Despite strong homology between subunits of AMPA-type glutamate receptors, heteromeric assemblies in different brain regions vary in subunit composition and functional properties. We have previously shown that charge substitution at K445 decreases th
Publikováno v:
Journal of Neurochemistry. 64:2004-2012
Neurons grown in culture die when they are exposed to high concentrations (0.1-1 mM) of the neurotransmitter L-glutamate. A similar phenomenon may occur in the mammalian brain during ischemia and other injuries that cause excessive glutamate release.
Autor:
David Robertson, Nannette M. Hale, Andrea L. Utz, Alvin C. Powers, Todd A. Verdoorn, Jeffery D. Fritz, Lan Wu
Publikováno v:
Journal of Neurochemistry. 68:204-212
The human glutamic acid decarboxylase (GAD) gene was transferred into rat cerebellar granule neurons. Following adenoviral-mediated gene transfer, nearly 100% of the neurons had transgene expression that persisted for the duration of their survival i
Autor:
Amit G. Gulwadi, Subramaniam Krishnananthan, Matthew T. Taber, Henry Wong, Thaddeus F. Molski, Carolyn D. Korpinen, Kai Xie, Cen Xu, Qi Gao, Elaine Ryan, Graham Johnson, Swanee Jacutin-Porte, Juliang Zhu, Todd A. Verdoorn, Kevin D. Burris, Sing-Yuen Sit
Publikováno v:
Journal of Medicinal Chemistry. 45:3660-3668
A highly convergent synthesis was developed for the novel dopamine agonist dinapsoline (12) (Ghosh, D.; Snyder, S. E.; Watts, V. J.; Mailman, R. B.; Nichols, D. E. 8,9-Dihydroxy-2,3,7, 11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: A Potent Full Dopam
Autor:
Nicola Norton, Michelle Alexander-Curtis, Jianmin Duan, Todd A. Verdoorn, Sam Salman, Ashley Seeklander, Simon Scott, Chin Lin Wong
Publikováno v:
International Journal of Clinical Trials. 4:139
Background: DM199 is a recombinant form of human tissue kallikrein (KLK1) that is being developed for ischemia-related diseases such as acute ischemic stroke. KLK1 is an important serine protease that promotes vasodilation and microcirculation in mul
Autor:
Gene M. Dubowchik, Karin Sipman, Vivekananda M. Vrudhula, Todd A. Verdoorn, Alexander Vinitsky, Bireshwar Dasgupta, Sagarika Bollini, Ti Chen, Steven Sheriff, Jeffrey Tredup, Dolatrai M. Vyas, Jonathan L. Ditta, Mark R. Witmer
Publikováno v:
Organic Letters. 3:3987-3990
[structure: see text] 2-Aryl-2,2-difluoroacetamido-proline and pipecolate esters are high affinity FKBP12 ligands whose rotamase inhibitory activity is comparable to that seen for the corresponding ketoamides. X-ray structural studies suggest that th