Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Todd A. Lydic"'
Autor:
Young-Hwa Goo, Janeesh Plakkal Ayyappan, Francis D. Cheeran, Sushant Bangru, Pradip K. Saha, Paula Baar, Sabine Schulz, Todd A. Lydic, Bernhard Spengler, Andreas H. Wagner, Auinash Kalsotra, Vijay K. Yechoor, Antoni Paul
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood. LD-associated hydrolase (LDAH) has a lipase structure and high affinity for LDs of foam cells.
Externí odkaz:
https://doaj.org/article/213b8383686e44778bff5f56edd70410
Autor:
Zhi-Hong Yang, Aruna Gorusupudi, Todd A. Lydic, Anupam K. Mondal, Seizo Sato, Isao Yamazaki, Hideaki Yamaguchi, Jingrong Tang, Krishna Vamsi Rojulpote, Anna B. Lin, Hannah Decot, Hannah Koch, Daniel C. Brock, Ranganathan Arunkumar, Zhen-Dan Shi, Zu-Xi Yu, Milton Pryor, Julia F. Kun, Rolf E. Swenson, Anand Swaroop, Paul S. Bernstein, Alan T. Remaley
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108411- (2023)
Summary: Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this field. We produced an n-3 C24-28-ri
Externí odkaz:
https://doaj.org/article/74a7d220a4254a238343bbd4e714de34
Autor:
Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds, Jr., J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101815- (2023)
Background and aims: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic
Externí odkaz:
https://doaj.org/article/2e4f326f6761408c9020ccde9aaab299
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Background Heart failure (HF) is one of the leading causes of death worldwide and is associated with cardiac metabolic perturbations. Human Type 2 Berardinelli‐Seip Congenital Lipodystrophy (BSCL2) disease is caused by mutations in the BSC
Externí odkaz:
https://doaj.org/article/f436642790d24c509f9a3215d2bf159b
Autor:
Martin-Paul Agbaga, Dana K. Merriman, Richard S. Brush, Todd A. Lydic, Shannon M. Conley, Muna I. Naash, Shelley Jackson, Amina S. Woods, Gavin E. Reid, Julia V. Busik, Robert E. Anderson
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1586-1596 (2018)
Long-chain PUFAs (LC-PUFAs; C20–C22; e.g., DHA and arachidonic acid) are highly enriched in vertebrate retina, where they are elongated to very-long-chain PUFAs (VLC-PUFAs; C ≥28) by the elongation of very-long-chain fatty acids-4 (ELOVL4) enzyme
Externí odkaz:
https://doaj.org/article/a20078d83b14410aaa6495dc9e364840
Autor:
Todd A. Lydic, Young-Hwa Goo
Publikováno v:
Clinical and Translational Medicine, Vol 7, Iss 1, Pp 1-13 (2018)
Abstract Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quant
Externí odkaz:
https://doaj.org/article/666aed300650435792499a841d40bbc9
Autor:
Mara Leimanis-Laurens, Emily Wolfrum, Karen Ferguson, Jocelyn R. Grunwell, Dominic Sanfilippo, Jeremy W. Prokop, Todd A. Lydic, Surender Rajasekaran
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 5, p 339 (2021)
Glycero- and sphingo-lipids are important in plasma membrane structure, caloric storage and signaling. An un-targeted lipidomics approach for a cohort of critically ill pediatric intensive care unit (PICU) patients undergoing multi-organ dysfunction
Externí odkaz:
https://doaj.org/article/429c3b7b027744f68888a76710536611
Autor:
Sandra S. Hammer, Eleni Beli, Nermin Kady, Qi Wang, Kiana Wood, Todd A. Lydic, Goldis Malek, Daniel R. Saban, Xiaoxin X. Wang, Sugata Hazra, Moshe Levi, Julia V. Busik, Maria B. Grant
Publikováno v:
EBioMedicine, Vol 22, Iss C, Pp 181-190 (2017)
Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, a cure for DR has yet to be realized.
Externí odkaz:
https://doaj.org/article/f73117b5dd974be191c934e1c359ea8d
Autor:
Mara L. Leimanis-Laurens, Karen Ferguson, Emily Wolfrum, Brian Boville, Dominic Sanfilippo, Todd A. Lydic, Jeremy W. Prokop, Surender Rajasekaran
Publikováno v:
Nutrients, Vol 13, Iss 3, p 774 (2021)
Lipids are molecules involved in metabolism and inflammation. This study investigates the plasma lipidome for markers of severity and nutritional status in critically ill children. Children with multi-organ dysfunction syndrome (MODS) (n = 24) are an
Externí odkaz:
https://doaj.org/article/fdf3be6d097340b1aea7246e0b3c2c1f
Autor:
Mara Leimanis-Laurens, Danny Gil, Andrew Kampfschulte, Claire Krohn, Elizabeth Prentice, Dominic Sanfilippo, Jeremy W. Prokop, Todd A. Lydic, Surender Rajasekaran
Publikováno v:
Children, Vol 8, Iss 2, p 151 (2021)
Metabolites are generated from critical biological functions and metabolism. This pediatric study reviewed plasma metabolites in patients suffering from multi-organ dysfunction syndrome (MODS) in the pediatric intensive care unit (PICU) using an unta
Externí odkaz:
https://doaj.org/article/3c7ef600137e44aaa77366666213761e