Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Todd A. Gillespie"'
Publikováno v:
The Journal of Organic Chemistry. 73:4888-4894
A mass spectrometric method is presented for the rapid identification of compounds that contain the aromatic N-oxide functional group. This method utilizes a gas-phase ion/molecule reaction with 2-methoxypropene that yields a stable adduct for proton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e61b335f61b5cbef1b0744cd8050969
https://doi.org/10.1021/jo800309u
https://doi.org/10.1021/jo800309u
Autor:
Atsushi Kurihara, T. James Rash, R L Smith, Todd A. Gillespie, Patrick E. Blair, Mark J. Goldberg, Nagy A. Farid
Publikováno v:
Drug Metabolism and Disposition. 35:1096-1104
Prasugrel, a prodrug, is a novel and potent inhibitor of platelet aggregation in vivo. The metabolism of prasugrel and the elimination and pharmacokinetics of its active metabolite, 2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-pipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bdec25c8a6284bd3a6ada1189b5010
https://doi.org/10.1124/dmd.106.014522
https://doi.org/10.1124/dmd.106.014522
Autor:
Enaksha R Wickremsinhe, Gurkeerat Singh, Todd A. Gillespie, Bradley L. Ackermann, Ajai K. Chaudhary
Publikováno v:
Current Drug Metabolism. 7:913-928
Although traditionally reserved for proteomic analysis, nanoESI has found increased use for small molecule applications related to drug metabolism/pharmacokinetics (DMPK). NanoESI, which refers to ESI performed at flow rates in the range of 200 to 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46f98d60fdd261a60026d29232f69fb
https://doi.org/10.2174/138920006779010610
https://doi.org/10.2174/138920006779010610
Autor:
Jason T. Johnson, Ping Yi, Barry C. Peterson, David A. Jackson, Todd A. Gillespie, Chad E. Hadden, William F. Annes
Publikováno v:
Drug Metabolism and Disposition. 35:51-61
Naveglitazar [LY519818; benzenepropanoic acid, alpha-methoxy-4-[3-(4-phenoxyphenoxy)propoxy], (alpha-S)-] is a nonthiozolidinedione peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist that has shown glucose-lowering po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb194141f5422312d383039626f2956c
https://doi.org/10.1124/dmd.106.012328
https://doi.org/10.1124/dmd.106.012328
Autor:
Claire Thalamas, Jaime Kulisevsky, Alison E Mackie, Todd A Gillespie, Alberto Lledó, Iris Rajman, Mary Seger, Olivier Rascol, Olivier Blin
Publikováno v:
Clinical Neuropharmacology. 28:120-125
The primary objective of this study was to describe the pharmacokinetics of oral pergolide in patients with mild to moderate Parkinson disease using a new high-performance liquid chromatography-tandem mass spectrometry assay. A secondary objective wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76055cd534079e52782e96d52a6ff478
https://doi.org/10.1097/01.wnf.0000168581.97083.9c
https://doi.org/10.1097/01.wnf.0000168581.97083.9c
Publikováno v:
Journal of Mass Spectrometry. 31:681-689
Packed capillary liquid chromatography/mass spectrometry (LC/MS) using electrospray ionization (ESI) was used to study the human biotransformation of the anti-emetic drug dolasetron. Urine from subjects given a single 100 mg intravenous dose, contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40017259348d7b1fd2e8d1b667a9ab0b
https://doi.org/10.1002/(sici)1096-9888(199606)31:6<681::aid-jms344>3.0.co
https://doi.org/10.1002/(sici)1096-9888(199606)31:6<681::aid-jms344>3.0.co
Autor:
Brian E. Winger, Todd A. Gillespie
Publikováno v:
Mass spectrometry reviews. 30(3)
Developing a pharmaceutical product has become increasingly difficult and expensive. With an emphasis on developing project knowledge at an earlier stage in development, the use of information-rich technologies (particularly MS) has continued to expa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ca769d80d680b1cee12abc99063b38
https://pubmed.ncbi.nlm.nih.gov/21500245
https://pubmed.ncbi.nlm.nih.gov/21500245
Publikováno v:
The Journal of organic chemistry. 74(3)
A mass spectrometric method is presented for the identification of compounds that contain the aliphatic or aromatic N-oxide functional group. This method utilizes gas-phase ion/molecule reactions of tri(dimethylamino)borane (TDMAB), which rapidly der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdda79b22f7305f0795130d1ede157f4
https://pubmed.ncbi.nlm.nih.gov/19133762
https://pubmed.ncbi.nlm.nih.gov/19133762
Autor:
Todd A. Gillespie, Richard A. Yost
Publikováno v:
Journal of the American Society for Mass Spectrometry. 1:389-396
Some intriguing discoveries were made concerning the collision-activated dissociation behavior of the derivatized car☐ylate anions of PGE2 and PGF2α. The car☐ylate anion [M-PFB]− formed from electron-capture negative chemical ionization of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44cc7597da60b41cca1d4fee0d23f25
https://doi.org/10.1016/1044-0305(90)85019-i
https://doi.org/10.1016/1044-0305(90)85019-i
Autor:
Sheerin Khatib-Shahidi, Richard M. Caprioli, Jennifer L. Herman, Malin Andersson, Todd A. Gillespie
Publikováno v:
Analytical chemistry. 78(18)
Imaging mass spectrometry (IMS) that utilizes matrix-assisted laser desorption/ionization (MALDI) technology can provide a molecular ex vivo view of resected organs or whole-body sections from an animal, making possible the label-free tracking of bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb56eb20a6f7e0dbaafb77c1dd9d312a
https://pubmed.ncbi.nlm.nih.gov/16970320
https://pubmed.ncbi.nlm.nih.gov/16970320