Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Todd A. Derksen"'
Publikováno v:
The Journal of Foot and Ankle Surgery. 56:996-1000
Total ankle replacement continues to become a more common treatment of end-stage ankle arthritis. A lateral approach total ankle implant system is an innovative approach for this treatment. We performed a retrospective review of 16 patients treated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62da7ae768c97ae1e241dfefe55c2afb
https://doi.org/10.1053/j.jfas.2017.04.016
https://doi.org/10.1053/j.jfas.2017.04.016
Autor:
Todd A. Derksen, Gail M. Seigel, Ari Kummer, Robert L. Nussbaum, Andrew J. Lotery, Beverly L. Davidson, Janet Wagner, Hannah M. Mitchison, Nicholas D. E. Greene, David J. Bernard, Mark Turmaine
Publikováno v:
Molecular and Cellular Neuroscience. 19:515-527
Batten disease or JNCL, is the juvenile form of Neuronal Ceroid Lipofuscinosis (NCL) an autosomal recessive neurodegenerative disorder. Since retinal degeneration is an early consequence of Batten disease, we examined the eyes of Cln3 knockout mice (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b8aa1b2c49e118ad7c0a8d64a56c3
https://doi.org/10.1006/mcne.2001.1099
https://doi.org/10.1006/mcne.2001.1099
Publikováno v:
The Journal of Gene Medicine. 4:463-469
Background Transduction of the murine retinal pigmented epithelium (RPE) with adenovirus vectors requires technically difficult and invasive subretinal injections. This study tested the hypothesis that recombinant vectors based on feline immunodefici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e10779bb2dd00f8d6cd353d8a9136c
https://doi.org/10.1002/jgm.267
https://doi.org/10.1002/jgm.267
Autor:
Jiahua Qian, Yubin Kang, Todd A. Derksen, Beverly L. Davidson, Inês Martins, Patrick D. Staber, Sybille L. Sauter, Kay Townsend, Paul B. McCray, Colleen S. Stein
Publikováno v:
Molecular Therapy. 3:850-856
Gene therapy holds great promise for the treatment of a variety of inherited diseases, including hemophilia A and mucopolysaccharidosis type VII (MPS VII). In both these disorders, subnormal levels of replacement protein have therapeutic effects. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee01fe961f174e7c7c6a2e74e50a99e
https://doi.org/10.1006/mthe.2001.0325
https://doi.org/10.1006/mthe.2001.0325
Autor:
Inês Martins, Abdi Ghodsi, Colleen S. Stein, Richard D. Anderson, Beverly L. Davidson, Todd A. Derksen
Publikováno v:
Experimental Neurology. 160:109-116
Mucopolysaccharidosis VII, a classical lysosomal storage disease, is caused by deficiency of the enzyme beta-glucuronidase. Central nervous system (CNS) manifestations are severe with accumulations of storage vacuoles in all cell types. Intraventricu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413e1a9cccaeff9a3c16cd5c6cb35997
https://doi.org/10.1006/exnr.1999.7205
https://doi.org/10.1006/exnr.1999.7205
Publikováno v:
Clinics in podiatric medicine and surgery. 25(3)
Surgery is a circumstance in which we know that we will cause pain. Although most of our perioperative pain management interventions are symptomatic, several strategies can reduce and even prevent pain in the perioperative setting. Because the physio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9742a918cdbe6bae4ba13374b1688b0
https://pubmed.ncbi.nlm.nih.gov/18486854
https://pubmed.ncbi.nlm.nih.gov/18486854
Autor:
Beverly L. Davidson, Colleen S. Stein, Jason A. Heth, Inês Martins, Robert M. Kotin, Todd A. Derksen, Joseph Zabner, Abdi Ghodsi, John A. Chiorini
Recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in the central nervous system (CNS), but it is not known how other rAAV serotypes perform as CNS gene transfer vectors. Serotypes 4 and 5 are disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3ace08f02b8a920f50ac130f86f9f2
https://europepmc.org/articles/PMC16256/
https://europepmc.org/articles/PMC16256/
Publikováno v:
Molecular genetics and metabolism. 66(4)
Juvenile neuronal ceroid lipofuscinosis is a lysosomal storage disease that causes visual impairment, progressive mental deterioration, and eventually death. A predominant 1.02-kb deletion as well as other mutations have been described in the CLN3 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30ee6e661f26ca7ea13b40d01198f2a
https://pubmed.ncbi.nlm.nih.gov/10191111
https://pubmed.ncbi.nlm.nih.gov/10191111
Mucopolysaccharidosis (MPS) type VII patients lack functional β-glucuronidase, leading to systemic and central nervous system dysfunction. In this study we tested whether recombinant adenovirus that encodes β-glucuronidase (Adβgluc), delivered int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9cc6b0fc6048a901389472c59f203b
https://europepmc.org/articles/PMC104107/
https://europepmc.org/articles/PMC104107/
Autor:
Colleen S. Stein, Richard D. Anderson, Abdi Ghodsi, Beverly L. Davidson, Todd A. Derksen, Gongyu Yang
Publikováno v:
Human gene therapy. 9(16)
Mucopolysaccharidosis type VII (MPS VII), caused by beta-glucuronidase deficiency, is a classic lysosomal storage disease. In the central nervous system (CNS), there is widespread pathology with distention of vacuoles in neurons and glia. An approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d6bc737f872137e9839e75fb42e8a8
https://pubmed.ncbi.nlm.nih.gov/9829532
https://pubmed.ncbi.nlm.nih.gov/9829532