Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Todd A., Wyatt"'
Autor:
Daniel N. Villageliu, Kelly C. Cunningham, Deandra R. Smith, Daren L. Knoell, Mason Mandolfo, Todd A. Wyatt, Derrick R. Samuelson
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Alcohol use is an independent risk factor for the development of bacterial pneumonia due, in part, to impaired mucus-facilitated clearance, macrophage phagocytosis, and recruitment of neutrophils. Alcohol consumption is also known to reduce
Externí odkaz:
https://doaj.org/article/b24db32e6ef64bb984d11f7fc9878577
Autor:
Abenaya Muralidharan, Christopher D. Bauer, Claire G. Nissen, St Patrick Reid, Jill A. Poole, Todd A. Wyatt
Publikováno v:
International Journal of Translational Medicine, Vol 4, Iss 3, Pp 486-497 (2024)
SARS-CoV-2, the causative agent of the COVID-19 pandemic, has had a global impact, affecting millions over the last three years. Pre-existing lung diseases adversely affect the prognosis of infected COVID-19 patients, and agricultural workers routine
Externí odkaz:
https://doaj.org/article/f4df159124bd4bafb18148b8694a5f77
Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures
Autor:
Aaron D. Schwab, Amy J. Nelson, Angela M. Gleason, Oliver W. Schanze, Todd A. Wyatt, Dhananjay D. Shinde, Peng Xiao, Vinai C. Thomas, Chittibabu Guda, Kristina L. Bailey, Tammy Kielian, Geoffrey M. Thiele, Jill A. Poole
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundEnvironmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations in
Externí odkaz:
https://doaj.org/article/086fbe7825ba451eb94481bbeca9982e
Autor:
Aaron D. Schwab, Todd A. Wyatt, Grace Moravec, Geoffrey M. Thiele, Amy J. Nelson, Angela Gleason, Oliver Schanze, Michael J. Duryee, Debra J. Romberger, Ted R. Mikuls, Jill A. Poole
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet
Externí odkaz:
https://doaj.org/article/679f8daa696f4b38867233ba2722837f
Autor:
Aaron D. Schwab, Todd A. Wyatt, Amy J. Nelson, Angela Gleason, Rohit Gaurav, Debra J. Romberger, Jill A. Poole
Publikováno v:
Journal of Immunotoxicology, Vol 21, Iss 1 (2024)
AbstractEfficacious therapeutic options capable of resolving inflammatory lung disease associated with environmental and occupational exposures are lacking. This study sought to determine the preclinical therapeutic potential of lung-delivered recomb
Externí odkaz:
https://doaj.org/article/2822d7a139e442fb86e7176047ee803e
Autor:
Christopher D. Bauer, Deanna D. Mosley, Derrick R. Samuelson, Jill A. Poole, Deandra R. Smith, Daren L. Knoell, Todd A. Wyatt
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 843 (2024)
Agricultural workers exposed to organic dust from swine concentrated animal feeding operations (CAFOs) have increased chances of contracting chronic lung disease. Mucociliary clearance represents a first line of defense against inhaled dusts, but org
Externí odkaz:
https://doaj.org/article/bcba136cfdfd4b22a1b30960b7148d84
Autor:
Amber N. Johnson, John Dickinson, Amy Nelson, Rohit Gaurav, Katrina Kudrna, Scott E. Evans, Katherine Janike, Todd A. Wyatt, Jill A. Poole
Publikováno v:
Journal of Immunotoxicology, Vol 20, Iss 1 (2023)
AbstractThe Toll-like receptor (TLR) adaptor protein MyD88 is integral to airway inflammatory response to microbial-enriched organic dust extract (ODE) exposures. ODE-induced airway neutrophil influx and release of pro-inflammatory cytokines was esse
Externí odkaz:
https://doaj.org/article/2c6de4d6bccc4edbb7e6d3dcb407396e
Autor:
Kristi J. Warren, Cassandra Deering-Rice, Tom Huecksteadt, Shubhanshi Trivedi, Alessandro Venosa, Christopher Reilly, Karl Sanders, Frederic Clayton, Todd A. Wyatt, Jill A. Poole, Nicola M. Heller, Daniel Leung, Robert Paine
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-17 (2023)
Highlights Steady levels of estrogen are associated with changes in allergic inflammation. When E2 is maintained at a level comparable to the mid-follicular phase of ovulation mucus production and airway hyperreactivity are increased. Estrogen reduce
Externí odkaz:
https://doaj.org/article/aae9a7bfdacf4c79abae740cad18bcf2
Autor:
Jill A. Poole, Rohit Gaurav, Aaron Schwab, Amy J. Nelson, Angela Gleason, Debra J. Romberger, Todd A. Wyatt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Although lung diseases typically result from long-term exposures, even a robust, one-time exposure can result in long-lasting consequences. Endotoxin is a ubiquitous environmental/occupational inflammatory agent often used to model airway in
Externí odkaz:
https://doaj.org/article/d9e34725e3f947fca0ec69cbdd3492d4
Autor:
Jill A. Poole, Ted R. Mikuls, Geoffrey M. Thiele, Rohit Gaurav, Amy J. Nelson, Michael J. Duryee, Ananya Mitra, Carlos Hunter, Todd A. Wyatt, Bryant R. England, Dana P. Ascherman
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Immunogenetic as well as environmental and occupational exposures have been linked to the development of rheumatoid arthritis (RA), RA-associated lung disease, and other primary lung disorders. Importantly, various inhalants can trigger post
Externí odkaz:
https://doaj.org/article/6715afcf5ca64ddfa7c719475c176126