Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Todd A Wyatt"'
Publikováno v:
Environmental Disease, Vol 5, Iss 4, Pp 93-99 (2020)
Objective: Exposure to organic barn dusts has been shown to cause numerous lung problems to chronically exposed animal barn workers. Bacterial components in these dusts trigger innate immunity in the lungs. In characterizing these responses, we exami
Externí odkaz:
https://doaj.org/article/17de9c53a48e42298333e1d9b04d73dd
Autor:
Rohit Gaurav, Ted R Mikuls, Geoffrey M Thiele, Amy J Nelson, Meng Niu, Chittibabu Guda, James D Eudy, Austin E Barry, Todd A Wyatt, Debra J Romberger, Michael J Duryee, Bryant R England, Jill A Poole
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0240707 (2021)
Rheumatoid arthritis (RA)-associated lung disease is a leading cause of mortality in RA, yet the mechanisms linking lung disease and RA remain unknown. Using an established murine model of RA-associated lung disease combining collagen-induced arthrit
Externí odkaz:
https://doaj.org/article/b35a055fe78f4c38bbfc6cdee9fc8df0
Autor:
Daniel N. Villageliu, Kelly C. Cunningham, Deandra R. Smith, Daren L. Knoell, Mason Mandolfo, Todd A. Wyatt, Derrick R. Samuelson
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Alcohol use is an independent risk factor for the development of bacterial pneumonia due, in part, to impaired mucus-facilitated clearance, macrophage phagocytosis, and recruitment of neutrophils. Alcohol consumption is also known to reduce
Externí odkaz:
https://doaj.org/article/b24db32e6ef64bb984d11f7fc9878577
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208597 (2018)
Prolonged exposure to organic barn dusts can lead to chronic inflammation and a broad range of lung problems over time, mediated by innate immune mechanisms. The immune surfactant or collectin surfactant protein D (SP-D) is a crucial multifunctional
Externí odkaz:
https://doaj.org/article/ccf5dd4092294cf49c3c9a94af96da30
Autor:
Abenaya Muralidharan, Christopher D. Bauer, Claire G. Nissen, St Patrick Reid, Jill A. Poole, Todd A. Wyatt
Publikováno v:
International Journal of Translational Medicine, Vol 4, Iss 3, Pp 486-497 (2024)
SARS-CoV-2, the causative agent of the COVID-19 pandemic, has had a global impact, affecting millions over the last three years. Pre-existing lung diseases adversely affect the prognosis of infected COVID-19 patients, and agricultural workers routine
Externí odkaz:
https://doaj.org/article/f4df159124bd4bafb18148b8694a5f77
Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures
Autor:
Aaron D. Schwab, Amy J. Nelson, Angela M. Gleason, Oliver W. Schanze, Todd A. Wyatt, Dhananjay D. Shinde, Peng Xiao, Vinai C. Thomas, Chittibabu Guda, Kristina L. Bailey, Tammy Kielian, Geoffrey M. Thiele, Jill A. Poole
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundEnvironmental lipopolysaccharide (LPS) and microbial component-enriched organic dusts cause significant lung disease. These environmental exposures induce the recruitment and activation of distinct lung monocyte/macrophage subpopulations in
Externí odkaz:
https://doaj.org/article/086fbe7825ba451eb94481bbeca9982e
Autor:
Elizabeth Staab, Geoffrey M Thiele, Dillon Clarey, Todd A Wyatt, Debra J Romberger, Adam D Wells, Anand Dusad, Dong Wang, Lynell W Klassen, Ted R Mikuls, Michael J Duryee, Jill A Poole
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0158735 (2016)
Agriculture workers have increased rates of airway and skeletal disease. Inhalant exposure to agricultural organic dust extract (ODE) induces bone deterioration in mice; yet, mechanisms underlying lung-bone crosstalk remain unclear. Because Toll-like
Externí odkaz:
https://doaj.org/article/89572b504b5742708a3b4607c7853190
Autor:
Aaron D. Schwab, Todd A. Wyatt, Grace Moravec, Geoffrey M. Thiele, Amy J. Nelson, Angela Gleason, Oliver Schanze, Michael J. Duryee, Debra J. Romberger, Ted R. Mikuls, Jill A. Poole
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet
Externí odkaz:
https://doaj.org/article/679f8daa696f4b38867233ba2722837f
Autor:
Kristi J Warren, Molly M Olson, Nicholas J Thompson, Mackenzie L Cahill, Todd A Wyatt, Kyoungjin J Yoon, Christina M Loiacono, Marian L Kohut
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129713 (2015)
Obesity has been associated with greater severity of influenza virus infection and impaired host defense. Exercise may confer health benefits even when weight loss is not achieved, but it has not been determined if regular exercise improves immune de
Externí odkaz:
https://doaj.org/article/8c011cacfff14e288cbc963d434ba37f
Autor:
Aaron D. Schwab, Todd A. Wyatt, Amy J. Nelson, Angela Gleason, Rohit Gaurav, Debra J. Romberger, Jill A. Poole
Publikováno v:
Journal of Immunotoxicology, Vol 21, Iss 1 (2024)
AbstractEfficacious therapeutic options capable of resolving inflammatory lung disease associated with environmental and occupational exposures are lacking. This study sought to determine the preclinical therapeutic potential of lung-delivered recomb
Externí odkaz:
https://doaj.org/article/2822d7a139e442fb86e7176047ee803e