Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Todd A, Gray"'
Autor:
Carol Smith, Jill G Canestrari, Archer J Wang, Matthew M Champion, Keith M Derbyshire, Todd A Gray, Joseph T Wade
Publikováno v:
eLife, Vol 11 (2022)
Most bacterial ORFs are identified by automated prediction algorithms. However, these algorithms often fail to identify ORFs lacking canonical features such as a length of >50 codons or the presence of an upstream Shine-Dalgarno sequence. Here, we us
Externí odkaz:
https://doaj.org/article/f95ff1f8c0b54ab4835c1b705bd552f1
Autor:
Alam García-Heredia, Takehiro Kado, Caralyn E Sein, Julia Puffal, Sarah H Osman, Julius Judd, Todd A Gray, Yasu S Morita, M Sloan Siegrist
Publikováno v:
eLife, Vol 10 (2021)
Many antibiotics target the assembly of cell wall peptidoglycan, an essential, heteropolymeric mesh that encases most bacteria. In rod-shaped bacteria, cell wall elongation is spatially precise yet relies on limited pools of lipid-linked precursors t
Externí odkaz:
https://doaj.org/article/5e854a09122b4a0eb05a1616a3d7f3aa
Autor:
Soneya Majumdar, Ayush Deep, Manjuli R. Sharma, Jill Canestrari, Melissa Stone, Carol Smith, Ravi K. Koripella, Pooja Keshavan, Nilesh K. Banavali, Joseph T. Wade, Todd A. Gray, Keith M. Derbyshire, Rajendra K. Agrawal
Publikováno v:
bioRxiv
Treatment of tuberculosis continues to be challenging due to the widespread latent form of the disease and the emergence of antibiotic-resistant strains of the pathogen,Mycobacterium tuberculosis. Bacterial ribosomes are a common and effective target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b6a6a1dc1cf2c92d3afa4c053a56ab
https://europepmc.org/articles/PMC10081302/
https://europepmc.org/articles/PMC10081302/
Publikováno v:
Cancer chemotherapy and pharmacology. 90(5)
To characterize the pharmacokinetics (PK) of zanidatamab including evaluation of the impact of intrinsic and extrinsic patient factors. To investigate alternative dosing regimens to improve caregiver convenience and reduce zanidatamab wastage.Serum z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c6482753c553f236f590b4e986d2b80
https://pubmed.ncbi.nlm.nih.gov/36102999
https://pubmed.ncbi.nlm.nih.gov/36102999
Autor:
Martina Rofaeil, Keith M. Derbyshire, Joseph T. Wade, Todd A. Gray, Erica Lasek-Nesselquist, Jill G. Canestrari, Matthew M. Champion, Ashutosh Upadhyay
Publikováno v:
Mol Microbiol
Genome-wide transcriptomic analyses have revealed abundant expressed short open reading frames (ORFs) in bacteria. Whether these short ORFs, or the small proteins they encode, are functional remains an open question. One quarter of mycobacterial mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cadb9e69c2695987857aa8ab6ebb46f
https://doi.org/10.1111/mmi.14498
https://doi.org/10.1111/mmi.14498
Autor:
Archer J Wang, Jill G Canestrari, Carol Smith, Matthew M Champion, Keith M Derbyshire, Todd A Gray, Joseph T Wade
Publikováno v:
eLife. 11
Most bacterial ORFs are identified by automated prediction algorithms. However, these algorithms often fail to identify ORFs lacking canonical features such as a length of >50 codons or the presence of an upstream Shine-Dalgarno sequence. Here, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9880fc2cb23634e60f3f178421505bac
https://doi.org/10.7554/elife.73980
https://doi.org/10.7554/elife.73980
Publikováno v:
J Bacteriol
In recent years, there has been increased appreciation that a whole category of proteins, small proteins of around 50 amino acids or fewer in length, has been missed by annotation as well as by genetic and biochemical assays. With the increased recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7175bfbf18530d38232df17a2e7bfedc
https://doi.org/10.1128/jb.00341-21
https://doi.org/10.1128/jb.00341-21
Autor:
Scarlet S Shell, Jing Wang, Pascal Lapierre, Mushtaq Mir, Michael R Chase, Margaret M Pyle, Richa Gawande, Rushdy Ahmad, David A Sarracino, Thomas R Ioerger, Sarah M Fortune, Keith M Derbyshire, Joseph T Wade, Todd A Gray
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005641 (2015)
RNA-seq technologies have provided significant insight into the transcription networks of mycobacteria. However, such studies provide no definitive information on the translational landscape. Here, we use a combination of high-throughput transcriptom
Externí odkaz:
https://doaj.org/article/cc14b07582f341739c4a970a97445956