Zobrazeno 1 - 10
of 562
pro vyhledávání: '"Todd A, Alonzo"'
Autor:
Abdelrahman H. Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H. K. Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, Josée Hébert, C. Michel Zwaan, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract In this study, we leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy (ara-C/daunorubicin/etoposide) in a discovery-cohort of pediatric AML patients (N = 163; NCT001360
Externí odkaz:
https://doaj.org/article/8d2e5546c18f4cf3998b81a1211405a0
Autor:
Kasey J. Leger, Michael J. Absalon, Biniyam G. Demissei, Amanda M. Smith, Robert B. Gerbing, Todd A. Alonzo, Hari K. Narayan, Betsy A. Hirsch, Jessica A. Pollard, Bassem I. Razzouk, Kelly D. Getz, Richard Aplenc, E. Anders Kolb, Bonnie Ky, Todd M. Cooper
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
IntroductionAnthracyclines are effective in treating acute myeloid leukemia (AML) but limited by cardiotoxicity. CPX-351, a liposomal daunorubicin and cytarabine, may provide therapeutic benefit with less cardiotoxicity. Acute changes in left ventric
Externí odkaz:
https://doaj.org/article/4f7d5c7ff98a44ee954f1d19f9442a1c
Autor:
Rachel Masch, Gabriel Conzuelo-Rodriguez, Jameson A Mitchell, Karla Alfaro, Montserrat Soler, Luis F Chavez, Suhui Wu, Jinfen Sun, Longhua Hu, Dayana Marinela-Hernandez, Todd A Alonzo, Juan C Felix, Miriam L Cremer
Publikováno v:
PLOS Global Public Health, Vol 4, Iss 7, p e0003333 (2024)
Although concerns have been raised regarding potential infection and morbidity in women undergoing ablation treatment for cervical precancer in low- and middle-income countries (LMIC), there is extremely limited data to substantiate this claim. This
Externí odkaz:
https://doaj.org/article/9877e322dc694510a66a0cd23f9b6875
Autor:
Anneke D. van Dijk, Fieke W. Hoff, Yihua Qiu, Stefan E. Hubner, Robin L. Go, Vivian R. Ruvolo, Amanda R. Leonti, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S. J. M. de Bont, Terzah M. Horton, Steven M. Kornblau
Publikováno v:
Cancers, Vol 16, Iss 8, p 1448 (2024)
The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children’s Oncology Group phase 3 trial AAML1031 (NCT0
Externí odkaz:
https://doaj.org/article/993a21e3ecff4ccfa59731e0c4b20ed8
Autor:
Yanling Liu, Jonathon Klein, Richa Bajpai, Li Dong, Quang Tran, Pandurang Kolekar, Jenny L. Smith, Rhonda E. Ries, Benjamin J. Huang, Yi-Cheng Wang, Todd A. Alonzo, Liqing Tian, Heather L. Mulder, Timothy I. Shaw, Jing Ma, Michael P. Walsh, Guangchun Song, Tamara Westover, Robert J. Autry, Alexander M. Gout, David A. Wheeler, Shibiao Wan, Gang Wu, Jun J. Yang, William E. Evans, Mignon Loh, John Easton, Jinghui Zhang, Jeffery M. Klco, Soheil Meshinchi, Patrick A. Brown, Shondra M. Pruett-Miller, Xiaotu Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, t
Externí odkaz:
https://doaj.org/article/4295bf024052418d8f3bd3d5099ce979
Autor:
Kasey J. Leger, Nora Robison, Hari K. Narayan, Amanda M. Smith, Tenaadam Tsega, Jade Chung, Amber Daniels, Zhen Chen, Virginia Englefield, Biniyam G. Demissei, Benedicte Lefebvre, Gemma Morrow, Ilona Dizon, Robert B. Gerbing, Reena Pabari, Kelly D. Getz, Richard Aplenc, Jessica A. Pollard, Eric J. Chow, W. H. Wilson Tang, William L. Border, Ritu Sachdeva, Todd A. Alonzo, E. Anders Kolb, Todd M. Cooper, Bonnie Ky
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundPediatric acute myeloid leukemia (AML) therapy is associated with substantial short- and long-term treatment-related cardiotoxicity mainly due to high-dose anthracycline exposure. Early left ventricular systolic dysfunction (LVSD) compromis
Externí odkaz:
https://doaj.org/article/b99055bf1d704eadae2a445572632039
Autor:
Benjamin J. Huang, Jenny L. Smith, Jason E. Farrar, Yi-Cheng Wang, Masayuki Umeda, Rhonda E. Ries, Amanda R. Leonti, Erin Crowgey, Scott N. Furlan, Katherine Tarlock, Marcos Armendariz, Yanling Liu, Timothy I. Shaw, Lisa Wei, Robert B. Gerbing, Todd M. Cooper, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Jeffrey Rubnitz, Jing Ma, Jeffery M. Klco, Xiaotu Ma, Todd A. Alonzo, Timothy Triche, Soheil Meshinchi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Relapsed pediatric acute myeloid leukemia is associated with poor prognosis. Here, the authors use RNA-seq data from 1503 primary samples to create a combined transcriptional and cytomolecular signature to improve relapse risk prediction.
Externí odkaz:
https://doaj.org/article/25d98e54e2234ca19a9e20931766c2ae
Autor:
Eline J.M. Bertrums, Jenny L. Smith, Lauren Harmon, Rhonda E. Ries, Yi-Cheng J. Wang, Todd A. Alonzo, Andrew J. Menssen, Karen M. Chisholm, Amanda R. Leonti, Katherine Tarlock, Fabiana Ostronoff, Era L. Pogosova-Agadjanyan, Gertjan J.L. Kaspers, Henrik Hasle, Michael Dworzak, Christiane Walter, Nora Muhlegger, Cristina Morerio, Laura Pardo, Betsy Hirsch, Susana Raimondi, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Jason E. Farrar, Derek Stirewalt, Xiaotu Ma, Tim I. Shaw, Scott N. Furlan, Lisa Eidenschink Brodersen, Michael R. Loken, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Timothy J. Triche, Bianca F. Goemans, Soheil Meshinchi
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
NUP98 fusions comprise a family of rare recurrent alterations in AML, associated with adverse outcomes. In order to define the underlying biology and clinical implications of this family of fusions, we performed comprehensive transcriptome, epigenome
Externí odkaz:
https://doaj.org/article/831b66d955b24822ab485927eae2ccd2
Autor:
Montserrat Soler, Karla Alfaro, Rachel J. Masch, Gabriel Conzuelo Rodriguez, Xinfeng Qu, Suhui Wu, Jingfen Sun, Dayana Marinela Hernández Jovel, Jairo Bonilla, Luis Orlando Puentes, Raúl Murillo, Todd A. Alonzo, Juan C. Felix, Philip Castle, Miriam Cremer
Publikováno v:
JCO Global Oncology, Vol , Iss 8 (2022)
PURPOSEThis ongoing trial is comparing the efficacy and safety of three ablation treatments for cervical intraepithelial neoplasia grade 2 or higher. Here, we present early data regarding pain, side effects, and acceptability of CO2 gas-based cryothe
Externí odkaz:
https://doaj.org/article/51988bc2a59e4a7b894825efbd792e54
Autor:
Karla Alfaro, Mauricio Maza, Juan C. Felix, Julia C. Gage, Philip E. Castle, Todd A. Alonzo, Andrea Chacón, Enrique González, Montserrat Soler, Gabriel Conzuelo-Rodriguez, Rachel Masch, Miriam Cremer
Publikováno v:
JCO Global Oncology, Vol , Iss 6, Pp 1519-1530 (2020)
PURPOSEThe Cervical Cancer Prevention in El Salvador (CAPE) project is a public-sector intervention introducing lower-cost human papillomavirus (HPV) testing in all four departments of the Paracentral region that screened a total of 28,015 women. Aft
Externí odkaz:
https://doaj.org/article/8459dfa1f09a4ff28c497c16d38327e2