Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Todd, Evans"'
Autor:
Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffré, Leah R. Sittenfeld, Jean-Luc Pasquié, Sarah Colombani, Bruce B. Lerman, Shuibing Chen, Andrew R. Marks, Jim W. Cheung, Todd Evans, Alain Lacampagne, Albano C. Meli
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac death, typically exercise-induced. We previously showed a link between
Externí odkaz:
https://doaj.org/article/b2abf9b16f7f43bea357aaac1049831c
Autor:
Liuliu Yang, Yuling Han, Ting Zhou, Lauretta A. Lacko, Mohsan Saeed, Christina Tan, Ron Danziger, Jiajun Zhu, Zeping Zhao, Clare Cahir, Alice Maria Giani, Yang Li, Xue Dong, Dorota Moroziewicz, Daniel Paull, Zhengming Chen, Aaron Zhong, Scott A. Noggle, Charles M. Rice, Qibin Qi, Todd Evans, Shuibing Chen
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107001- (2023)
Summary: Population-based genome-wide association studies (GWAS) normally require a large sample size, which can be labor intensive and costly. Recently, we reported a human induced pluripotent stem cell (hiPSC) array-based GWAS method, identifying N
Externí odkaz:
https://doaj.org/article/692df0b5246247cd9c258ce33dcea793
Autor:
Zaniar Ghazizadeh, Jiajun Zhu, Faranak Fattahi, Alice Tang, Xiaolu Sun, Sadaf Amin, Su-Yi Tsai, Mona Khalaj, Ting Zhou, Ryan M. Samuel, Tuo Zhang, Francis A. Ortega, Miriam Gordillo, Dorota Moroziewicz, Daniel Paull, Scott A. Noggle, Jenny Zhaoying Xiang, Lorenz Studer, David J. Christini, Geoffrey S. Pitt, Todd Evans, Shuibing Chen
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104153- (2022)
Summary: The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust in vitro derivation methods. We developed a dual SHOX2:GFP; MYH6:mCherry knock
Externí odkaz:
https://doaj.org/article/fef061437c7f48f58546ebc077cf20d3
Publikováno v:
Molecules, Vol 28, Iss 3, p 1052 (2023)
Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed dearomative borylation process to synthe
Externí odkaz:
https://doaj.org/article/5eb5181aea1f46509c11a895dbc88202
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103118- (2021)
Summary: The mitochondrial unfolded protein response (UPRmt) is an organellar stress signaling pathway that functions to detect and restore disruption of mitochondrial proteostasis. The UPRmt is involved in a wide range of physiological and disease c
Externí odkaz:
https://doaj.org/article/7a3b87242f724bb4be9f4e17be69edae
Autor:
Lei Tan, Lauretta A. Lacko, Ting Zhou, Delia Tomoiaga, Romulo Hurtado, Tuo Zhang, Ana Sevilla, Aaron Zhong, Christopher E Mason, Scott Noggle, Todd Evans, Heidi Stuhlmann, Robert E. Schwartz, Shuibing Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Here, using human cells and mouse models, the authors show that Zika virus can infect preimplantation trophectoderm. Pre-implantation infection can affect nervous system development and survival of neural progenitors, and can result in miscarriage or
Externí odkaz:
https://doaj.org/article/cc5622b5dfc04f5d988bdfabb453be0c
Autor:
Heejin Lee, Todd Evans
Publikováno v:
iScience, Vol 19, Iss , Pp 267-280 (2019)
Summary: Wnt/β-catenin signaling is regulated in a bimodal fashion during cardiogenesis. Signaling is initially required to promote generation of precardiac mesoderm, but subsequently must be repressed for cardiac progenitor specification. TMEM88 wa
Externí odkaz:
https://doaj.org/article/fd771480fb93437b91c1e5f9e5aa6734
Autor:
Zohreh Sadat Badieyan, Todd Evans
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 8, Pp 833-843 (2019)
Abstract Chemically modified RNA (cmRNA) has potential as a safe and efficient tool for nucleic acid‐based therapies and regenerative medicine. Modifications in the chemistry of mRNA can enhance stability, reduce immunogenicity, and thus facilitate
Externí odkaz:
https://doaj.org/article/b0e0a128c3684c42b8361a81a157c416
Autor:
Lei Yang, Rodolfo J. Ricart Arbona, Carl S. Smith, Kelly M. Banks, V. Kaye Thomas, Lawrence Palmer, Todd Evans, Romulo Hurtado
Publikováno v:
The Journal of Physiology. 601:1225-1246
Although HCN ion channels are well established to underlie cardiac pacemaker activity, their role in smooth muscle organs remains controversial. HCN expressing cells are localized to renal pelvic smooth muscle (RPSM) pacemaker tissues of the murine u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f86ba581311afb836130e21be3f03f7
https://doi.org/10.1113/jp283701
https://doi.org/10.1113/jp283701
Autor:
Xuming Tang, Dongxiang Xue, Tuo Zhang, Benjamin E. Nilsson-Payant, Lucia Carrau, Xiaohua Duan, Miriam Gordillo, Adrian Y. Tan, Yunping Qiu, Jenny Xiang, Robert E. Schwartz, Benjamin R. tenOever, Todd Evans, Shuibing Chen
Publikováno v:
Nature Cell Biology. 25:381-389
COVID-19 is a systemic disease involving multiple organs. We previously established a platform to derive organoids and cells from human pluripotent stem cells to model SARS-CoV-2 infection and perform drug screens1,2. This provided insight into cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17d7bb44756cd47fab5a0335aba02169
https://doi.org/10.1038/s41556-023-01095-y
https://doi.org/10.1038/s41556-023-01095-y