Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Todd, Duncan"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The ratio of saturated to monounsaturated fatty acids, thought to play a critical role in many cellular functions, is regulated by stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Prev
Externí odkaz:
https://doaj.org/article/4f14d21c9ad54fb0a314a6e4bab619f9
Autor:
Saumil Sethna, Patrick A. Scott, Arnaud P. J. Giese, Todd Duncan, Xiaoying Jian, Sheikh Riazuddin, Paul A. Randazzo, T. Michael Redmond, Steven L. Bernstein, Saima Riazuddin, Zubair M. Ahmed
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and subse
Externí odkaz:
https://doaj.org/article/28f9c426a95d413a8bcf70e1675378bc
Autor:
Saumil Sethna, Wadih M Zein, Sehar Riaz, Arnaud PJ Giese, Julie M Schultz, Todd Duncan, Robert B Hufnagel, Carmen C Brewer, Andrew J Griffith, T Michael Redmond, Saima Riazuddin, Thomas B Friedman, Zubair M Ahmed
Publikováno v:
eLife, Vol 10 (2021)
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of PCDH15 (USH1F) has an ~2% carrier frequency amongst Ashkenazi Jews accounts for
Externí odkaz:
https://doaj.org/article/b6069badb6b14498bff5ec71588e5683
Autor:
W. Todd Duncan, Lisa E. Colvin
Publikováno v:
Journal of Systemics, Cybernetics and Informatics, Vol 16, Iss 2, Pp 23-28 (2018)
Any number of school districts in the U.S. are having to improve schools that have been underperforming by state and federal measures. Research has indicated that one of the ways to effectively improve school performance is by reconstituting the scho
Externí odkaz:
https://doaj.org/article/4f76a726602145f9a6af0b34b831b0ec
Autor:
Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B Gutierrez, Nathan L Mata, T Michael Redmond
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176487 (2017)
The therapeutic capacity of fenretinide (N-[4-hydroxyphenyl] retinamide; 4-HPR) has been demonstrated for several conditions, including cancer, obesity, diabetes, and ocular disease. Yet, the mechanisms of action for its pleiotropic effects are still
Externí odkaz:
https://doaj.org/article/814b6ba31e1e4c1cbfa7997dd61c4ec9
The ratio of saturated to monounsaturated fatty acids, thought to play a critical role in many cellular functions, is regulated by stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Previously, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709359690503a15c2b437599aa8fc45e
https://doi.org/10.21203/rs.3.rs-1972330/v1
https://doi.org/10.21203/rs.3.rs-1972330/v1
Autor:
Julie M. Schultz, Zubair M. Ahmed, Robert B. Hufnagel, Todd Duncan, Sehar Riaz, Carmen C. Brewer, Thomas B. Friedman, Andrew J. Griffith, Saumil Sethna, Arnaud P. J. Giese, T. Michael Redmond, Wadih M. Zein, Saima Riazuddin
Publikováno v:
eLife, Vol 10 (2021)
Usher syndrome type I (USH1) is characterized by deafness, vestibular areflexia, and progressive retinal degeneration. The protein-truncating p.Arg245* founder variant of PCDH15 (USH1F) has an ~2% carrier frequency amongst Ashkenazi Jews accounts for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621209fffa1c8dcf4db479e49dd880b1
https://doi.org/10.7554/elife.67361
https://doi.org/10.7554/elife.67361
Autor:
Arnaud P. J. Giese, Saumil Sethna, Julie M. Schultz, Sehar Riaz, Andrew J. Griffith, T. Michael Redmond, Wadih M. Zein, Thomas B. Friedman, Carmen C. Brewer, Saima Riazuddin, Zubair Ahmed, Robert B. Hufnagel, Todd Duncan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f6c18299b0970e362d21d1291c42a3c
https://doi.org/10.7554/elife.67361.sa2
https://doi.org/10.7554/elife.67361.sa2
Autor:
Saima Riazuddin, Zubair M. Ahmed, Robert B. Hufnagel, Todd Duncan, Sehar Riaz, T M Redmond, Arnaud P. J. Giese, Andrew J. Griffith, Carmen C. Brewer, Saumil Sethna, Thomas B. Friedman, Wadih M. Zein, Julie M. Schultz
Usher syndrome type I (USH1) is characterized by congenital deafness, vestibular areflexia, and progressive retinal degeneration with age. The protein-truncating p.Arg245* founder variant of PCDH15 has an ~2% carrier frequency among Ashkenazi Jews, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cad16a601dca337a4948cf4e28cba329
https://doi.org/10.1101/2021.06.08.447565
https://doi.org/10.1101/2021.06.08.447565
Autor:
Rashid M. Mahdi, Todd Duncan, Vijender Chaitankar, Eugenia Poliakov, Amanda Ray, Lijin Dong, T. Michael Redmond, Igor B. Rogozin, Linn Gieser, Rachel Furhang, Pinghu Liu, Joseph Soucy, Yan Li, Haohua Qian
Publikováno v:
Human Mutation. 40:426-443
Human RPE65 mutations cause a spectrum of retinal dystrophies that result in blindness. While RPE65 mutations have been almost invariably recessively inherited, a c.1430A>G (p.(D477G)) mutation has been reported to cause autosomal dominant retinitis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a3e618a93af7d8fde50f4aa57918cc
https://doi.org/10.1002/humu.23706
https://doi.org/10.1002/humu.23706