Výsledky vyhledávání - "Tod M. Klingler"

Drawing networks of rejection - a systems biological approach to the identification of candidate genes in heart transplantation

Autor: Manuel Prinz von Bayern, Esteban G. Tabak, Anshu Sinha, Wei Keat Lim, Hernan E. Grenett, Tod M. Klingler, Farhana Latif, Andrea Califano, Mario C. Deng, Martin Cadeiras, Khurram Shahzad

Publikováno v: Journal of Cellular and Molecular Medicine

Technological development led to an increased interest in systems biological approaches to characterize disease mechanisms and candidate genes relevant to specific diseases. We suggested that the human peripheral blood mononuclear cells (PBMC) networ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345967c9abe50861abf0f7fac21daa57
https://doi.org/10.1111/j.1582-4934.2010.01092.x

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Clinical Implications and Longitudinal Alteration of Peripheral Blood Transcriptional Signals Indicative of Future Cardiac Allograft Rejection

Autor: Patricia A. Uber, Daniel F. Pauly, Russell Dedrick, Mandeep R. Mehra, Srinivas Murali, Michael G. Walker, Howard J. Eisen, Jon A. Kobashigawa, Tod M. Klingler, Randall C. Starling, Preeti Lal, Steven Rosenberg, Mario C. Deng, Kenneth C. Fang, Adriana Zeevi

Publikováno v: The Journal of Heart and Lung Transplantation. 27:297-301

Background We have previously demonstrated that a peripheral blood transcriptional profile using 11 distinct genes predicts onset of cardiac allograft rejection weeks to months prior to the actual event. Methods In this analysis, we ascertained the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5783eca32b489cc0a9d260678b6bca39
https://doi.org/10.1016/j.healun.2007.11.578

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Gene Expression Profiling Distinguishes a Molecular Signature for Grade 1B Mild Acute Cellular Rejection in Cardiac Allograft Recipients

Autor: Jon A. Kobashigawa, Seema Mital, Gavin E. Williams, Howard J. Eisen, Daniel Bernstein, Tod M. Klingler, Mario C. Deng, Kenneth C. Fang, Jay Wohlgemuth

Publikováno v: The Journal of Heart and Lung Transplantation. 26:1270-1280

Gene expression profiling distinguishes the absence or presence of moderate to severe grades of acute cellular rejection in cardiac allograft recipients using a 20-gene classifier. We explored the hypothesis that the rejection classifier also differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e099a19c182ee37e7216631ae8907c4b
https://doi.org/10.1016/j.healun.2007.09.017

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Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy

Autor: Anshu Sinha, Martin Cadeiras, Khurram Shahzad, Sreevalsa Unniachan, Esteban G. Tabak, Tod M. Klingler, Sarfaraz Memon, Barry Zeeberg, Mario C. Deng

Publikováno v: Journal of Transplantation
Journal of Transplantation, Vol 2010 (2010)

Background. Cardiac allograft vasculopathy (CAV) is a major cause of graft loss and death after heart transplantation. Currently, no diagnostic methods are available during the early post-transplant period to accurately identify patients at risk of C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d0588f3f5a978897d1fa8440b155fd

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Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts

Autor: Adriana Zeevi, Russell Dedrick, Jon A. Kobashigawa, Steven Rosenberg, Daniel F. Pauly, Howard J. Eisen, Michael G. Walker, Srinivas Murali, Mandeep R. Mehra, Preeti Lal, Randall C. Starling, Tod M. Klingler, Patricia A. Uber, Mario C. Deng, Kenneth C. Fang

Publikováno v: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 26(12)

Profiling mRNA levels of 11 informative genes expressed by circulating immune effector cells identifies cardiac allograft recipients at low risk for current moderate-severe acute cellular rejection (ACR).We conducted a nested case-control study of 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affe083fd510d93ea7e389fd90ae4945
https://pubmed.ncbi.nlm.nih.gov/18096476

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Abstract 4870: GenePool: A cloud-based technology for rapidly data mining large-scale, patient-derived cancer genomic cohorts including The Cancer Genome Atlas

Autor: Vladimirova Antoaneta Petkova, Sandeep Sanga, Tod M. Klingler, Richard D. Goold

Publikováno v: Cancer Research. 75:4870-4870

GenePool is a cloud-based system for the secure storage, management, analysis, visualization and interpretation of large-scale human genomics data. The GenePool platform enables rapid interrogation of massive amounts of data generated by current labo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9f20711957109fc78eafd1ee07d6e6f
https://doi.org/10.1158/1538-7445.am2015-4870

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Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes

Autor: Wayne Volkmuth, Tod M. Klingler, David M. Hodgson, Einat A. Sprinzak, Michael G. Walker

We wish to identify genes associated with disease. To do so, we look for novel genes whose expression patterns mimic those of known disease-associated genes, using a method we call Guilt-by-Association (GBA), on the basis of a combinatoric measure of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2151eded03c5e399e256f4d912bae16
https://europepmc.org/articles/PMC310991/

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