Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tod J. Merkel"'
Autor:
Parul Kapil, Yihui Wang, Kelsey Gregg, Lindsey Zimmerman, Damaris Molano, Jonatan Maldonado Villeda, Peter Sebo, Tod J. Merkel
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT Whole-cell pertussis (wP) vaccines introduced in the 1940s led to a dramatic reduction of pertussis incidence and are still widely used in low- and middle-income countries (LMICs) worldwide. The reactogenicity of wP vaccines resulted in redu
Externí odkaz:
https://doaj.org/article/5f567cc0d2c84db2969b14c68d7c195c
Autor:
Tracy L. Nicholson, Ursula Waack, Damarius S. Fleming, Qing Chen, Laura C. Miller, Tod J. Merkel, Scott Stibitz
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Bordetella bronchiseptica is a highly contagious respiratory bacterial veterinary pathogen. In this study the contribution of the transcriptional regulators BvgR, RisA, RisS, and the phosphorylation of RisA to global gene regulation, intracellular cy
Externí odkaz:
https://doaj.org/article/5edfd29f8a474e468f0b0e409d86ca01
Autor:
Kelsey A. Gregg, Tod J. Merkel
Publikováno v:
Toxins, Vol 11, Iss 10, p 557 (2019)
B. pertussis is a human-specific pathogen and the causative agent of whooping cough. The ongoing resurgence in pertussis incidence in high income countries is likely due to faster waning of immunity and increased asymptomatic colonization in individu
Externí odkaz:
https://doaj.org/article/b2152c502aa546cca4258b87f02ba6bc
Autor:
Kelsey A Gregg, Yihui Wang, Jason Warfel, Elizabeth Schoenfeld, Ewa Jankowska, John F Cipollo, Matthew Mayho, Christine Boinett, Deepika Prasad, Timothy J Brickman, Sandra K Armstrong, Julian Parkhill, Ricardo Da Silva Antunes, Alessandro Sette, James F Papin, Roman Wolf, Tod J Merkel
Publikováno v:
J Infect Dis
Background Despite high vaccination rates, the United States has experienced a resurgence in reported cases of pertussis after switching to the acellular pertussis vaccine, indicating a need for improved vaccines that enhance infection control. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bd78475aae0dae44995b4732a86adb
Autor:
Parul Kapil, Tod J. Merkel
Publikováno v:
Curr Opin Immunol
Despite high vaccine coverage, reported cases of pertussis have increased steadily over the last twenty years. This resurgence has stimulated interest in host responses to pertussis infection and vaccination with the goal of developing more effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d022053716e5bc1b771b980a0d470b5
https://doi.org/10.1016/j.coi.2019.03.006
https://doi.org/10.1016/j.coi.2019.03.006
Autor:
Benjamin M. Althouse, Shelly Bolotin, Natasha S. Crowcroft, Tod J. Merkel, Rodger Craig, Lindsay Friedman, Meagan C. Fitzpatrick, Hester de Melker, Elizabeth Kunkel, Katia Koelle, Samuel V. Scarpino, Callum Arnold
Publikováno v:
Clinical Infectious Diseases. 70:152-161
We conducted a systematic review to describe the frequency of mild, atypical, and asymptomatic infection among household contacts of pertussis cases and to explore the published literature for evidence of asymptomatic transmission. We included studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71de462465da8769b73b551b8c22fffe
https://doi.org/10.1093/cid/ciz531
https://doi.org/10.1093/cid/ciz531
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59232 (2013)
In vivo bioluminescent imaging permits the visualization of bacteria in live animals, allowing researchers to monitor, both temporally and spatially, the progression of infection in each animal. We sought to engineer stably luminescent clinical strai
Externí odkaz:
https://doaj.org/article/609f4cb21c134ff7aec4824f10111916
Autor:
Rebecca A Brady, Christopher P Mocca, Ranjani Prabhakara, Roger D Plaut, Mark E Shirtliff, Tod J Merkel, Drusilla L Burns
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e63040 (2013)
Staphylococcus aureus is a major human pathogen and a leading cause of nosocomial and community-acquired infections. Development of a vaccine against this pathogen is an important goal. While S. aureus protective antigens have been identified in the
Externí odkaz:
https://doaj.org/article/2ab44dbdde434c21a5a69b938e1a8456
Autor:
Thomas R. Kozel, Ryan K Olsen, James J Dunn, Jacqueline Scarbrough, Lindsey Zimmerman, Amanda R. Burnham-Marusich, Wei Yang, Tod J. Merkel, Alexander J. Kvam
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Pertussis is a highly contagious disease for which prompt, point-of-care diagnosis remains an unmet clinical need. Results from conventional test modalities (nucleic acid detection, serology, and culture) take hours to days. To overcome this challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716bfe023422a94acdb805e66464227f
https://doi.org/10.1038/s41598-020-72092-6
https://doi.org/10.1038/s41598-020-72092-6
Autor:
Aaron Sutherland, Alessandro Sette, Ferran Soldevila, Bjoern Peters, Tod J. Merkel, Timothy J. Brickman, Sandra K. Armstrong, Sandeep Kumar Dhanda, Ricardo da Silva Antunes, Lorenzo Quiambao
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2020 (2020)
Journal of Immunology Research, Vol 2020 (2020)
The immune response elicited by the protective whole-cell pertussis (wP) versus the less-protective acellular pertussis (aP) vaccine has been well characterized; however, important clinical problems remain unsolved, as the inability of the currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f440c582489ce3d71948fc5f12396bd6