Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Toby W. Allen"'
Autor:
Carus H. Y. Lau, Emelie Flood, Mark J. Hunter, Billy J. Williams-Noonan, Karen M. Corbett, Chai-Ann Ng, James C. Bouwer, Alastair G. Stewart, Eduardo Perozo, Toby W. Allen, Jamie I. Vandenberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go related gene (HERG) potassium channels have u
Externí odkaz:
https://doaj.org/article/972987d550f34a1a8904b0996298240b
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 9, p e1006398 (2018)
Bacterial and human voltage-gated sodium channels (Navs) exhibit similar cation selectivity, despite their distinct EEEE and DEKA selectivity filter signature sequences. Recent high-resolution structures for bacterial Navs have allowed us to learn ab
Externí odkaz:
https://doaj.org/article/deffa5ff784a496fb2484b6909bed900
Autor:
Timothy Lynagh, Emelie Flood, Céline Boiteux, Matthias Wulf, Vitaly V Komnatnyy, Janne M Colding, Toby W Allen, Stephan A Pless
Publikováno v:
eLife, Vol 6 (2017)
Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in
Externí odkaz:
https://doaj.org/article/1350a5c1730a41c381d865b7cfbe34e4
Publikováno v:
J Chem Theory Comput
Despite the progress in modeling complex molecular systems of ever-increasing complexity, a quantitatively accurate computational treatment of ion permeation through narrow membrane channels remains challenging. An important factor to reach this goal
Autor:
Carus Lau, Emelie Flood, Mark Hunter, Karen Corbett, Chai Ng, James Bouwer, Alastair Stewart, Eduardo Perozo, Toby W. Allen, Jamie Vandenberg
Publikováno v:
Biophysical Journal. 122:446a
Autor:
Ronald J. Clarke, Bogdan Lev, Milna Chennath, Toby W. Allen, Charles G. Cranfield, Emma-Lucille Blayney, Flemming Cornelius
Publikováno v:
Biophysical Journal. 122:529a
Publikováno v:
Nature, 580(7802), 288-293. Nature Publishing Group
Nature
Nature
Inactivation is the process by which ion channels terminate ion flux through their pores while the opening stimulus is still present1. In neurons, inactivation of both sodium and potassium channels is crucial for the generation of action potentials a
Autor:
Charles D. Cox, Risa Shibuya, Donna R. Whelan, Amy Li, Emi Hibino, Toby W. Allen, Charles G. Cranfield, Keith E. Shearwin, Kumiko Hayashi, Cristobal G. dos Remedios, Joshua Ho
Publikováno v:
Biophysical Reviews
This Commentary describes a call for submissions for the upcoming Special Issue focused on the research topics presented at the Australian Society of Biophysics (ASB) in 2020 and 2021. Submissions from past and present ASB members who could not atten
Autor:
Bogdan Lev, Thi Hanh Nguyen Pham, Alvaro Garcia, Amy Gorman, Flemming Cornelius, Toby W. Allen, Dil Diaz, Khondker R. Hossain, Ronald J. Clarke
Publikováno v:
Garcia, A, Lev, B, Hossain, K R, Gorman, A, Diaz, D, Thi Hanh Nguyen Pham,, Cornelius, F, Allen, T W & Clarke, R J 2019, ' Cholesterol depletion inhibits Na+,K+-ATPase activity in a near-native membrane environment ', Journal of Biological Chemistry, vol. 294, no. 15, pp. 5956-5969 . https://doi.org/10.1074/jbc.RA118.006223
Cholesterol’s effects on Na+,K+-ATPase reconstituted in phospholipid vesicles have been extensively studied. However, previous studies have reported both cholesterol-mediated stimulation and inhibition of Na+,K+-ATPase activity. Here, using partial