Výsledky vyhledávání

Hypoxic Blackwater Events - Identifying High Risk Catchments in Estuaries Now and Under Future Climate Scenarios

Autor: Katrina Waddington, Alice Harrison, Duncan Rayner, Toby Tucker, William Glamore

Hypoxic blackwater events occur worldwide, affecting inland and coastal waters. These events have been exacerbated by man-made floodplain drainage, leading to large-scale fish kills and ecological degradation. This paper presents a new method to iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c75928a1617766a2d00774f5a2460650
https://doi.org/10.22541/essoar.168167360.03118440/v1

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A multiplex immunofluorescence assay to assess immune checkpoint inhibitor-targeted CD8 activation and tumor colocalization in FFPE tissues

Autor: Tony Navas, Facundo Cutuli, Ralph E. Parchment, James H. Doroshow, Kristin Fino, Alice P. Chen, Toby Tucker Hecht, Aditi Sharma, Robert J. Kinders, Geraldine O'Sullivan-Coyne, King Leung Fung

Publikováno v: Journal of Clinical Oncology. 37:2629-2629

2629 Background: Immune checkpoint inhibitors promote antitumor immune responses by enhancing T-cell activity. Measuring the pharmacodynamic effects of these drugs is challenging, as it requires assessing both immune cell and cancer cell populations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98506e1a216ce52394f645b8008c1143
https://doi.org/10.1200/jco.2019.37.15_suppl.2629

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Antitumor Activity of Hu14.18-IL2 in Patients With Relapsed/Refractory Neuroblastoma: A Children's Oncology Group (COG) Phase II Study

Autor: Brian Gadbaw, Robert C. Seeger, Paul M. Sondel, Susan L. Cohn, C. Patrick Reynolds, John M. Maris, Jacek Gan, Wendy B. London, Stephen D. Gillies, Ralph A. Reisfeld, Barrett Wagner, Suzanne Shusterman, Mark R. Albertini, Jens C. Eickhoff, Jacquelyn A. Hank, Jennifer Kimball, Stephan D. Voss, Toby Tucker Hecht, Kenneth B. DeSantes

Publikováno v: Journal of Clinical Oncology. 28:4969-4975

Purpose The hu14.18-IL2 fusion protein consists of interleukin-2 molecularly linked to a humanized monoclonal antibody that recognizes the GD2 disialoganglioside expressed on neuroblastoma cells. This phase II study assessed the antitumor activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915bfb34d313cf4056326ac35f390e7c
https://doi.org/10.1200/jco.2009.27.8861

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Akademický článek

A Great Capacity for Grief.

Autor: HECHT, TOBY TUCKER

Publikováno v: Jelly Bucket; 2018, Issue 8, p107-119, 13p

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Anti-neuroblastoma activity of hu14.18-IL2 against minimal residual disease in a Children’s Oncology Group (COG) phase II study

Autor: Ralph A. Reisfeld, Wendy B. London, Stephan D. Voss, Stephen D. Gillies, John M. Maris, Paul M. Sondel, Jacquelyn A. Hank, Toby Tucker Hecht, Seeger Rc, Suzanne Shusterman

Publikováno v: Journal of Clinical Oncology. 26:3002-3002

3002 Background: The hu14.18-IL2 fusion protein consists of IL2 linked to a humanized mAb that recognizes the GD2 disialoganglioside expressed on neuroblastoma (NB) cells. Hu14.18-IL2 has preclinical activity in mouse models of NB and melanoma, parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::699458a2c3ac38c03ba44f244de6acd5
https://doi.org/10.1200/jco.2008.26.15_suppl.3002

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