Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Toby Passioura"'
Autor:
Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110426- (2024)
Summary: The regenerative functions associated with cytokines and growth factors have immense therapeutic potential; however, their poor pharmacokinetics, resulting from structural features, hinder their effectiveness. In this study, we aimed to enha
Externí odkaz:
https://doaj.org/article/0d8d58bd76f444259d5c7598ca8e3f20
Autor:
Alexander Norman, Charlotte Franck, Mary Christie, Paige M. E. Hawkins, Karishma Patel, Anneliese S. Ashhurst, Anupriya Aggarwal, Jason K. K. Low, Rezwan Siddiquee, Caroline L. Ashley, Megan Steain, James A. Triccas, Stuart Turville, Joel P. Mackay, Toby Passioura, Richard J. Payne
Publikováno v:
ACS Central Science, Vol 7, Iss 6, Pp 1001-1008 (2021)
Externí odkaz:
https://doaj.org/article/0a46d203a8ab4df88c42556e3ac1d0dd
Autor:
Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation, but selective inhibition remains a challenge. Here the authors identify potent inhibitors of KDM4A-C—viain vitroselection from a vast library of cyclic pe
Externí odkaz:
https://doaj.org/article/ef8ec2f09725496691198a2fa7af4d88
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 116 (2018)
Macrocyclic peptides are an emerging class of bioactive compounds for therapeutic use. In part, this is because they are capable of high potency and excellent target affinity and selectivity. Over the last decade, several biochemical techniques have
Externí odkaz:
https://doaj.org/article/1e7f91ccf8964c8787986bf9f7c11dc1
Publikováno v:
Biomedicines, Vol 6, Iss 4, p 99 (2018)
Flexible in vitro translation (FIT) was used as a screening method to uncover a new methodology for peptide constraining based on the attack of a nucleophilic side-chain functionality onto an oxidized furylalanine side chain. A set of template peptid
Externí odkaz:
https://doaj.org/article/8e1dc8d9eddd4acc93d5c2467ce163d1
Publikováno v:
Molecules, Vol 18, Iss 3, Pp 3502-3528 (2013)
In this review, we discuss emerging technologies for drug discovery, which yields novel molecular scaffolds based on natural product-inspired non-traditional peptides expressed using the translation machinery. Unlike natural products, these technolog
Externí odkaz:
https://doaj.org/article/0c593565c6754ce9a71f51c96c0a90a8
Autor:
Shota Warashina, Hiroki Sato, Maki Zouda, Maiko Takahashi, Yasuhiro Wada, Toby Passioura, Hiroaki Suga, Yasuyoshi Watanabe, Kunio Matsumoto, Hidefumi Mukai
Publikováno v:
Molecular Pharmaceutics. 20:2029-2038
Autor:
Jason K K Low, Karishma Patel, Paul Solomon, Alexander Norman, Petr Pachl, Natasha Jones, Richard J Payne, Toby Passioura, Hiroaki Suga, Louise J Walport, Joel P Mackay
Bromodomains regulate gene expression by recognizing protein motifs containing acetyllysine. Although originally characterized as histone-binding proteins, it has since become clear that these domains interact with other acetylated proteins, perhaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27ab2199ddb8297634faec9650223e54
https://doi.org/10.1101/2023.05.17.541126
https://doi.org/10.1101/2023.05.17.541126
Table S1-S6 from N-Ras–Induced Growth Suppression of Myeloid Cells Is Mediated by IRF-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6f9b7d794e0d6ac35538f088883cce
https://doi.org/10.1158/0008-5472.22365000
https://doi.org/10.1158/0008-5472.22365000
An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold
Autor:
Christina N. Zdenek, Simon J. de Veer, Hiroaki Suga, Bryan G. Fry, Toby Passioura, Joakim E. Swedberg, Wenyu Liu, Chikako Okada, David J. Craik, Toru Sengoku, Kazuhiro Ogata, Yen-Hua Huang
Publikováno v:
Journal of the American Chemical Society. 143:18481-18489
Cyclotides are plant-derived peptides with complex structures shaped by their head-to-tail cyclic backbone and cystine knot core. These structural features underpin the native bioactivities of cyclotides, as well as their beneficial properties as pha